Publication Date:
2010-01-23
Description:
Current methods for differentiating isolates of predominant lineages of pathogenic bacteria often do not provide sufficient resolution to define precise relationships. Here, we describe a high-throughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of a dominant strain of methicillin-resistant Staphylococcus aureus (MRSA). This approach reveals the global geographic structure within the lineage, its intercontinental transmission through four decades, and the potential to trace person-to-person transmission within a hospital environment. The ability to interrogate and resolve bacterial populations is applicable to a range of infectious diseases, as well as microbial ecology.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821690/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821690/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harris, Simon R -- Feil, Edward J -- Holden, Matthew T G -- Quail, Michael A -- Nickerson, Emma K -- Chantratita, Narisara -- Gardete, Susana -- Tavares, Ana -- Day, Nick -- Lindsay, Jodi A -- Edgeworth, Jonathan D -- de Lencastre, Herminia -- Parkhill, Julian -- Peacock, Sharon J -- Bentley, Stephen D -- 076964/Wellcome Trust/United Kingdom -- Department of Health/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2010 Jan 22;327(5964):469-74. doi: 10.1126/science.1182395.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 15A, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20093474" target="_blank"〉PubMed〈/a〉
Keywords:
Asia/epidemiology
;
Bacterial Typing Techniques
;
Cross Infection/epidemiology/*microbiology/transmission
;
Europe/epidemiology
;
Evolution, Molecular
;
*Genome, Bacterial
;
Genomics/methods
;
Humans
;
Likelihood Functions
;
Methicillin-Resistant Staphylococcus aureus/*classification/*genetics/isolation &
;
purification
;
Molecular Epidemiology
;
Molecular Sequence Data
;
Phylogeny
;
Polymorphism, Single Nucleotide
;
Sequence Analysis, DNA
;
South America/epidemiology
;
Staphylococcal Infections/epidemiology/*microbiology/transmission
;
Time Factors
;
United States/epidemiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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