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  • 1
    Publication Date: 2012-10-11
    Description: Author(s): Rajdeep M. Chatterjee, Monoranjan Guchait, and Dipan Sengupta We have revisited the prospects of supersymmetry searches at the LHC with 7 TeV energy along with the prediction of the discovery potential at 8 TeV energy assuming an integrated luminosity 5  fb -1 and 20  fb -1 with minimal supergravity/minimal supersymmetric standard model as a model framework. We ... [Phys. Rev. D 86, 075014] Published Wed Oct 10, 2012
    Keywords: Beyond the standard model
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
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  • 2
    Publication Date: 2012-09-11
    Description: Author(s): Diptimoy Ghosh, Monoranjan Guchait, Sreerup Raychaudhuri, and Dipan Sengupta We study the allowed parameter space of the constrained minimal supersymmetric Standard Model (cMSSM) in the light of direct searches, constraints from B -physics (including the recent measurement of the branching ratio for B s → μ + μ - ) and the dark matter relic density. For low or moderate values of tan... [Phys. Rev. D 86, 055007] Published Mon Sep 10, 2012
    Keywords: Beyond the standard model
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
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  • 3
    Publication Date: 2012-02-23
    Description: Author(s): Monoranjan Guchait, D. P. Roy, and Dipan Sengupta We have analyzed the prospect of probing a nonuniversal gaugino mass model of mixed bino-Higgsino dark matter at the current 7 TeV run of LHC. It provides cosmologically compatible dark matter relic density over two broad bands of parameters, corresponding to m g ˜ 〈 m q ˜ and m g ˜ ∼ m q ˜ . The supersymmetr... [Phys. Rev. D 85, 035024] Published Wed Feb 22, 2012
    Keywords: Beyond the standard model
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
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  • 4
    Publication Date: 2011-09-14
    Description: Author(s): Monoranjan Guchait and Dipan Sengupta We investigate the prospects of supersymmetry searches at the LHC with 7 TeV energy. A new set of selection cuts is proposed based on event shapes to control backgrounds. Our preliminary studies show that it is possible to minimize backgrounds to a significantly low level and a conservative estimate... [Phys. Rev. D 84, 055010] Published Tue Sep 13, 2011
    Keywords: Beyond the standard model
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
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  • 5
    Publication Date: 2014-05-20
    Description: Author(s): Soumyajit Bose, Anindya Sengupta, and Arnab K. Ray We subject the stationary solutions of inviscid and axially symmetric rotational accretion to a time-dependent radial perturbation, which includes nonlinearity to any arbitrary order. Regardless of the order of nonlinearity, the equation of the perturbation bears a form that is similar to the metric... [Phys. Rev. D 89, 103011] Published Mon May 19, 2014
    Keywords: Astrophysics
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
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  • 6
    Publication Date: 2012-12-12
    Description: Mouse primordial germ cells (PGCs) undergo sequential epigenetic changes and genome-wide DNA demethylation to reset the epigenome for totipotency. Here, we demonstrate that erasure of CpG methylation (5mC) in PGCs occurs via conversion to 5-hydroxymethylcytosine (5hmC), driven by high levels of TET1 and TET2. Global conversion to 5hmC initiates asynchronously among PGCs at embryonic day (E) 9.5 to E10.5 and accounts for the unique process of imprint erasure. Mechanistically, 5hmC enrichment is followed by its protracted decline thereafter at a rate consistent with replication-coupled dilution. The conversion to 5hmC is an important component of parallel redundant systems that drive comprehensive reprogramming in PGCs. Nonetheless, we identify rare regulatory elements that escape systematic DNA demethylation in PGCs, providing a potential mechanistic basis for transgenerational epigenetic inheritance.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847602/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847602/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hackett, Jamie A -- Sengupta, Roopsha -- Zylicz, Jan J -- Murakami, Kazuhiro -- Lee, Caroline -- Down, Thomas A -- Surani, M Azim -- 079249/Wellcome Trust/United Kingdom -- 083089/Wellcome Trust/United Kingdom -- 083563/Wellcome Trust/United Kingdom -- 092096/Wellcome Trust/United Kingdom -- RG44593/Wellcome Trust/United Kingdom -- RG49135/Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2013 Jan 25;339(6118):448-52. doi: 10.1126/science.1229277. Epub 2012 Dec 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23223451" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Methylcytosine/metabolism ; Animals ; CpG Islands ; Cytosine/*analogs & derivatives/metabolism ; *DNA Methylation ; DNA-Binding Proteins/genetics/metabolism ; Embryo, Mammalian/*metabolism ; Embryonic Development ; *Epigenesis, Genetic ; Female ; *Genomic Imprinting ; Germ Cells/*metabolism ; Germ Layers/cytology ; Male ; Mice ; Promoter Regions, Genetic ; Proto-Oncogene Proteins/genetics/metabolism ; RNA-Binding Proteins/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2012-06-23
    Description: How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment stem-cell function in response to calorie restriction. Calorie restriction acts by reducing mechanistic target of rapamycin complex 1 (mTORC1) signalling in Paneth cells, and the ISC-enhancing effects of calorie restriction can be mimicked by rapamycin. Calorie intake regulates mTORC1 in Paneth cells, but not ISCs, and forced activation of mTORC1 in Paneth cells during calorie restriction abolishes the ISC-augmenting effects of the niche. Finally, increased expression of bone stromal antigen 1 (Bst1) in Paneth cells-an ectoenzyme that produces the paracrine factor cyclic ADP ribose-mediates the effects of calorie restriction and rapamycin on ISC function. Our findings establish that mTORC1 non-cell-autonomously regulates stem-cell self-renewal, and highlight a significant role of the mammalian intestinal niche in coupling stem-cell function to organismal physiology.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387287/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387287/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yilmaz, Omer H -- Katajisto, Pekka -- Lamming, Dudley W -- Gultekin, Yetis -- Bauer-Rowe, Khristian E -- Sengupta, Shomit -- Birsoy, Kivanc -- Dursun, Abdulmetin -- Yilmaz, V Onur -- Selig, Martin -- Nielsen, G Petur -- Mino-Kenudson, Mari -- Zukerberg, Lawrence R -- Bhan, Atul K -- Deshpande, Vikram -- Sabatini, David M -- 1F32AG032833-01A1/AG/NIA NIH HHS/ -- CA103866/CA/NCI NIH HHS/ -- CA129105/CA/NCI NIH HHS/ -- F32 AG032833/AG/NIA NIH HHS/ -- P30 AG038072/AG/NIA NIH HHS/ -- P30 DK043351/DK/NIDDK NIH HHS/ -- R01 CA103866/CA/NCI NIH HHS/ -- R01 CA129105/CA/NCI NIH HHS/ -- T32CA09216/CA/NCI NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2012 Jun 28;486(7404):490-5. doi: 10.1038/nature11163.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22722868" target="_blank"〉PubMed〈/a〉
    Keywords: ADP-ribosyl Cyclase/metabolism ; Animals ; Antigens, CD/metabolism ; Caloric Restriction ; Cell Count ; Cell Division/drug effects ; Cyclic ADP-Ribose/metabolism ; Energy Intake/*physiology ; Female ; GPI-Linked Proteins/agonists/metabolism ; Intestines/*cytology ; Longevity/physiology ; Male ; Mice ; Multiprotein Complexes ; Paneth Cells/*cytology/drug effects/*metabolism ; Paracrine Communication ; Proteins/antagonists & inhibitors/*metabolism ; Regeneration/drug effects ; Signal Transduction ; Sirolimus/pharmacology ; Stem Cell Niche/drug effects/*physiology ; Stem Cells/*cytology/drug effects/*metabolism ; TOR Serine-Threonine Kinases
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2019-07-19
    Description: Young, hot gas giant planets at large separations from their primaries have been directly imaged around several nearby stars. More such planets will likely be detected by ongoing and new imaging surveys with instruments such as the Gemini Planet Imager (GPI). Efforts continue to model the spectra of these planets in order to constrain their masses, effective temperatures, composition, and cloud structure. One potential tool for analyzing these objects, which has received relatively less attention, is polarization. Linear polarization of gas giant exoplanets can arise from the combined influences of light scattering by atmospheric dust and a rotationally distorted shape. The oblateness of gas giant planet increases of course with rotation rate and for fixed rotation also rises with decreasing gravity. Thus young, lower mass gas giant planets with youthful inflated radii could easily have oblateness greater than that of Saturn s 10%. We find that polarizations of over 1% may easily be produced in the near-infrared in such cases. This magnitude of polarization may be measurable by GPI and other instruments. Thus if detected, polarization of a young Jupiter places constraints on the combination of its gravity, rotation rate, and degree of cloudiness. We will present results of our multiple scattering analysis coupled with a self-consistent dusty atmospheric models to demonstrate the range of polarizations that might be expected from resolved exoplanets and the range of parameter space that such observations may inform.
    Keywords: Astrophysics
    Type: 42nd Annual Meeting of the Division of Planetary Sciences; Oct 03, 2012 - Oct 08, 2012; Pasadena, CA; United States
    Format: application/pdf
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