Publication Date:
2011-02-26
Description:
Kinesin motor proteins are thought to move exclusively in either one or the other direction along microtubules. Proteins of the kinesin-5 family are tetrameric microtubule cross-linking motors important for cell division and differentiation in various organisms. Kinesin-5 motors are considered to be plus-end-directed. However, here we found that purified kinesin-5 Cin8 from budding yeast could behave as a bidirectional kinesin. On individual microtubules, single Cin8 motors were minus-end-directed motors, whereas they switched to plus-end-directed motility when working in a team of motors sliding antiparallel microtubules apart. This kinesin can thus change directionality of movement depending on whether it acts alone or in an ensemble.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roostalu, Johanna -- Hentrich, Christian -- Bieling, Peter -- Telley, Ivo A -- Schiebel, Elmar -- Surrey, Thomas -- New York, N.Y. -- Science. 2011 Apr 1;332(6025):94-9. doi: 10.1126/science.1199945. Epub 2011 Feb 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Zentrum fur Molekulare Biologie der Universitat Heidelberg, DKFZ-ZMBH Allianz, Im Neuenheimer Feld 282, Heidelberg 69120, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21350123" target="_blank"〉PubMed〈/a〉
Keywords:
Kinesin/*physiology
;
Microtubules/physiology
;
Molecular Motor Proteins/*physiology
;
Recombinant Proteins
;
Saccharomyces cerevisiae/physiology
;
Saccharomyces cerevisiae Proteins/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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