Publication Date:
2011-05-21
Description:
Tan et al. (Reports, 25 September 2009, p. 1686) argued that loss of tyrosine residues from proteins in metazoans was driven by positive selection to remove potentially deleterious phosphorylation sites. We challenge this hypothesis, providing evidence that the high guanine-cytosine (GC) content of metazoan genomes was the primary driver in the loss of tyrosine residues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Su, Zhixi -- Huang, Wei -- Gu, Xun -- New York, N.Y. -- Science. 2011 May 20;332(6032):917; author reply 917. doi: 10.1126/science.1187374.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences, Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21596977" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Base Composition
;
*Biological Evolution
;
Choanoflagellata/chemistry/genetics
;
Evolution, Molecular
;
Fungal Proteins/chemistry
;
*Genome
;
Phosphorylation
;
Protein-Tyrosine Kinases/metabolism
;
Proteins/*chemistry
;
Protozoan Proteins/chemistry
;
Saccharomycetales/chemistry/genetics
;
*Selection, Genetic
;
Tyrosine/*chemistry
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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