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  • ACS (American Chemical Society)  (5)
  • American Society for Microbiology  (3)
  • Spanish Society for Microbiology (SEM)
  • 2010-2014  (9)
  • 1
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    Bacterial isolates from the bryozoan Membranipora membranacea: influence of culture media on isolation and antimicrobioal activity (2012)
    Spanish Society for Microbiology (SEM)
    In:  International Microbiology, 15 (1). pp. 17-32.
    Details
    Publication Date: 2017-05-30
    Description: From specimens of the bryozoan Membranipora membranacea collected in the Baltic Sea, bacteria were isolated on four different media, which significantly increased the diversity of the isolated groups. All isolates were classifiedaccording to 16S rRNA gene sequence analysis and tested for antimicrobial properties using a panel of five indicator strainsand six different media. Each medium featured a unique set of isolated phylotypes, and a phylogenetically diverse collection of isolates was obtained. A total of 96 isolates were assigned to 49 phylotypes and 29 genera. Only one-third of the members of these genera had been isolated previously from comparable sources. The isolates were affiliated with Alpha- and Gammaproteobacteria, Bacilli, and Actinobacteria. A comparable large portion of up to 22 isolates, i.e., 15 phylotypes, probably represent new species. Likewise, 47 isolates (approximately 50%) displayed antibiotic activities, mostly against grampositive indicator strains. Of the active strains, 63.8 % had antibiotic traits only on one or two of the growth media, whereas only 12.7 % inhibited growth on five or all six media. The application of six different media for antimicrobial testing resulted in twice the number of positive hits as obtained with only a single medium. The use of different media for the isolation of bacteria as well as the variation of media considered suitable for the production of antibiotic substances significantly enhanced both the number of isolates obtained and the proportion of antibiotic active cultures. Thus the approach described herein offers an improved strategy in the search for new antibiotic compounds
    Type: Article , PeerReviewed
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  • 2
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    Mayamycin, a Cytotoxic Polyketide from aStreptomycesStrain Isolated from the Marine SpongeHalichondria panicea (2010)
    ACS (American Chemical Society)
    In:  Journal of Natural Products, 73 (7). pp. 1309-1312.
    Details
    Publication Date: 2019-10-17
    Description: A new benz[a]anthracene derivative called mayamycin (1) was identified in cultures of Streptomyces sp. strain HB202, which was isolated from the marine sponge Halichondria panicea and selected because of its profound antibiotic activity. The ability to produce aromatic polyketides was indicated by genetic analyses, demonstrating the presence of a type II polyketide synthase. The production of mayamycin (1) was induced by variation of the culture conditions. The structure of 1 was elucidated by HPLC-UV/MS and NMR spectroscopy. Mayamycin (1) exhibited potent cytotoxic activity against eight human cancer cell lines and showed activity against several bacteria including antibiotic-resistant strains.
    Type: Article , PeerReviewed
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  • 3
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    Eutypoids B−E Produced by aPenicilliumsp. Strain from the North Sea (2011)
    ACS (American Chemical Society)
    In:  Journal of Natural Products, 74 (1). pp. 99-101.
    Details
    Publication Date: 2019-10-17
    Description: Crude extracts of the Penicillium sp. strain KF620 isolated from the North Sea showed antimicrobial activities against Xanthomonas campestris and Candida glabrata. Purification of the extracts led to the isolation of the new aromatic butenolides eutypoids B (1), C (2), D (3), and E (4). Their structures were elucidated by NMR spectroscopy and supported by HRESIMS and UV data. The antibacterial activity of the crude extracts was due to the presence of the known diketopiperazine fellutanine (cyclo(Trp-Trp)). The eutypoids were neither cytotoxic nor antibacterial, but inhibited the activity of glycogen synthase kinase-3β
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  • 4
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    Nocapyrones A−D, γ-Pyrones from aNocardiopsisStrain Isolated from the Marine SpongeHalichondria panicea (2010)
    ACS (American Chemical Society)
    In:  Journal of Natural Products, 73 (8). pp. 1444-1447.
    Details
    Publication Date: 2020-10-16
    Description: Four new γ-pyrones, nocapyrones A−D (1−4), were isolated from an organic extract of the Nocardiopsis strain HB383, which was isolated from the marine sponge Halichondria panicea. These are the first γ-pyrones reported from a Nocardiopsis strain. The structures were elucidated on the basis of one- and two-dimensional NMR experiments and supported by HPLC-UV/MS and HRESIMS analyses. The biosynthesis of nocapyrone A was investigated by feeding experiments with 13C-labeled compounds. In addition, one diketopiperazine, which was only known as a synthetic compound before, was isolated. The bioactivies of 1, 2, and the diketopiperazine were evaluated in a panel of assays.
    Type: Article , PeerReviewed
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  • 5
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    Genome Sequence of Bacillus subtilis subsp. spizizenii gtP20b, Isolated from the Indian Ocean (2011)
    American Society for Microbiology
    In:  Journal of Bacteriology, 193 (5). pp. 1276-1277.
    Details
    Publication Date: 2019-09-23
    Description: Bacillus subtilis is an aerobic spore-forming Gram-positive bacterium that is a model organism and of great industrial significance as the source of diverse novel functional molecules. Here we present, to our knowledge, the first genome sequence of Bacillus subtilis strain gtP20b isolated from the marine environment. A subset of candidate genes and gene clusters were identified, which are potentially involved in production of diverse functional molecules, like novel ribosomal and nonribosomal antimicrobial peptides. The genome sequence described in this paper is due to its high strain specificity of great importance for basic as well as applied researches on marine organisms
    Type: Article , PeerReviewed
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  • 6
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    Draft Genome Sequence of the Marine Streptomyces sp. Strain PP-C42, Isolated from the Baltic Sea (2011)
    American Society for Microbiology
    In:  Journal of Bacteriology, 193 (14). pp. 3691-3692.
    Details
    Publication Date: 2017-07-03
    Description: Streptomyces, a branch of aerobic Gram-positive bacteria represents the largest genus of actinobacteria. The streptomycetes are characterized by a complex secondary metabolism and produce over two-thirds of the clinically used natural antibiotics today. Here we report the draft genome sequence of a Streptomyces strain PP-C42 isolated from the marine environment. A subset of unique genes and gene clusters for diverse secondary metabolites as well as antimicrobial peptides (AMPs) could be identified from the genome, showing great promise as a source for novel bioactive compounds
    Type: Article , PeerReviewed
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  • 7
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    Comprehensive Investigation of Marine Actinobacteria Associated with the Sponge Halichondria panicea (2010)
    American Society for Microbiology
    In:  Applied and Environmental Microbiology, 76 (11). pp. 3702-3714.
    Details
    Publication Date: 2019-09-23
    Description: Representatives of Actinobacteria were isolated from the marine sponge Halichondria panicea collected from the Baltic Sea (Germany). For the first time, a comprehensive investigation was performed with regard to phylogenetic strain identification, secondary metabolite profiling, bioactivity determination, and genetic exploration of biosynthetic genes, especially concerning the relationships of the abundance of biosynthesis gene fragments to the number and diversity of produced secondary metabolites. All strains were phylogenetically identified by 16S rRNA gene sequence analyses and were found to belong to the genera Actinoalloteichus, Micrococcus, Micromonospora, Nocardiopsis, and Streptomyces. Secondary metabolite profiles of 46 actinobacterial strains were evaluated, 122 different substances were identified, and 88 so far unidentified compounds were detected. The extracts from most of the cultures showed biological activities. In addition, the presence of biosynthesis genes encoding polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) in 30 strains was established. It was shown that strains in which either PKS or NRPS genes were identified produced a significantly higher number of metabolites and exhibited a larger number of unidentified, possibly new metabolites than other strains. Therefore, the presence of PKS and NRPS genes is a good indicator for the selection of strains to isolate new natural products.
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  • 8
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    Calcaripeptides A–C, Cyclodepsipeptides from aCalcarisporiumStrain (2013)
    ACS (American Chemical Society)
    In:  Journal of Natural Products, 76 (8). pp. 1461-1467.
    Details
    Publication Date: 2019-10-17
    Description: The isolation and structure elucidation of the novel calcaripeptides A (1), B (2), and C (3) and studies on their biosynthetic origin are described. The calcaripeptides were identified from Calcarisporium sp. strain KF525, which was isolated from the German Wadden Sea. Compounds 1–3 are macrocyclic structures composed of a proline and a phenylalanine residue as well as a nonpeptidic substructure. Structure elucidation was achieved by applying one- and two-dimensional NMR spectroscopy supported by high-resolution mass spectrometry. X-ray crystallography was performed to determine the relative configuration of 1. The absolute configuration of 1 was assigned by HPLC of the amino acids after hydrolysis of the molecule and derivatization with chiral agents. Studies on the biosynthesis by feeding 13C-labeled substrates revealed that the nonpeptidic part of 1 originates from acetate and l-methionine. The involvement of a hybrid between a polyketide synthase and a nonribosomal peptide synthetase in the biosynthesis of the calcaripeptides is discussed.
    Type: Article , PeerReviewed , info:eu-repo/semantics/article
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  • 9
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    Geranylphenazinediol, an Acetylcholinesterase Inhibitor Produced by a Streptomyces Species (2012)
    ACS (American Chemical Society)
    In:  Journal of Natural Products, 75 (7). pp. 1400-1404.
    Details
    Publication Date: 2019-10-17
    Description: Geranylphenazinediol (1), a new phenazine natural product, was produced by the Streptomyces sp. strain LB 173, which was isolated from a marine sediment sample. The structure was established by analysis of NMR and MS data 1 inhibited the enzyme acetylcholinesterase in the low micromolar range and showed weak antibacterial activity. In order to get a more detailed picture of the activity profile of 1, its inhibitory potential was compared to that of related structures.
    Type: Article , PeerReviewed
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