Publication Date:
2011-10-08
Description:
Understanding the genetic bases and modes of adaptation to current climatic conditions is essential to accurately predict responses to future environmental change. We conducted a genome-wide scan to identify climate-adaptive genetic loci and pathways in the plant Arabidopsis thaliana. Amino acid-changing variants were significantly enriched among the loci strongly correlated with climate, suggesting that our scan effectively detects adaptive alleles. Moreover, from our results, we successfully predicted relative fitness among a set of geographically diverse A. thaliana accessions when grown together in a common environment. Our results provide a set of candidates for dissecting the molecular bases of climate adaptations, as well as insights about the prevalence of selective sweeps, which has implications for predicting the rate of adaptation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hancock, Angela M -- Brachi, Benjamin -- Faure, Nathalie -- Horton, Matthew W -- Jarymowycz, Lucien B -- Sperone, F Gianluca -- Toomajian, Chris -- Roux, Fabrice -- Bergelson, Joy -- GM083068/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2011 Oct 7;334(6052):83-6. doi: 10.1126/science.1209244.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21980108" target="_blank"〉PubMed〈/a〉
Keywords:
Acclimatization/*genetics
;
Adaptation, Physiological/genetics
;
Alleles
;
Arabidopsis/*genetics/growth & development/*physiology
;
Asia
;
*Climate
;
Climate Change
;
Energy Metabolism
;
Europe
;
*Genetic Fitness
;
Genetic Pleiotropy
;
*Genome, Plant
;
Genome-Wide Association Study
;
Linkage Disequilibrium
;
*Polymorphism, Single Nucleotide
;
*Selection, Genetic
;
Temperature
;
Water
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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