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  • Animals  (3)
  • *Genetic Fitness  (1)
  • Plasma and Beam Physics
  • Processing fishery products
  • American Association for the Advancement of Science (AAAS)  (4)
  • 2010-2014  (4)
  • 1945-1949
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  • 1
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    Cell lineage reconstruction of early zebrafish embryos using label-free nonlinear microscopy (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-08-21
    Description: Quantifying cell behaviors in animal early embryogenesis remains a challenging issue requiring in toto imaging and automated image analysis. We designed a framework for imaging and reconstructing unstained whole zebrafish embryos for their first 10 cell division cycles and report measurements along the cell lineage with micrometer spatial resolution and minute temporal accuracy. Point-scanning multiphoton excitation optimized to preferentially probe the innermost regions of the embryo provided intrinsic signals highlighting all mitotic spindles and cell boundaries. Automated image analysis revealed the phenomenology of cell proliferation. Blastomeres continuously drift out of synchrony. After the 32-cell stage, the cell cycle lengthens according to cell radial position, leading to apparent division waves. Progressive amplification of this process is the rule, contrasting with classical descriptions of abrupt changes in the system dynamics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Olivier, Nicolas -- Luengo-Oroz, Miguel A -- Duloquin, Louise -- Faure, Emmanuel -- Savy, Thierry -- Veilleux, Israel -- Solinas, Xavier -- Debarre, Delphine -- Bourgine, Paul -- Santos, Andres -- Peyrieras, Nadine -- Beaurepaire, Emmanuel -- New York, N.Y. -- Science. 2010 Aug 20;329(5994):967-71. doi: 10.1126/science.1189428.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Optics and Biosciences, Ecole Polytechnique, CNRS, INSERM, Palaiseau, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20724640" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blastula/cytology ; Cell Cycle ; *Cell Lineage ; Embryo, Nonmammalian/*cytology ; Image Processing, Computer-Assisted ; Microscopy/*methods ; Zebrafish/*embryology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Adaptation to climate across the Arabidopsis thaliana genome (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-10-08
    Description: Understanding the genetic bases and modes of adaptation to current climatic conditions is essential to accurately predict responses to future environmental change. We conducted a genome-wide scan to identify climate-adaptive genetic loci and pathways in the plant Arabidopsis thaliana. Amino acid-changing variants were significantly enriched among the loci strongly correlated with climate, suggesting that our scan effectively detects adaptive alleles. Moreover, from our results, we successfully predicted relative fitness among a set of geographically diverse A. thaliana accessions when grown together in a common environment. Our results provide a set of candidates for dissecting the molecular bases of climate adaptations, as well as insights about the prevalence of selective sweeps, which has implications for predicting the rate of adaptation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hancock, Angela M -- Brachi, Benjamin -- Faure, Nathalie -- Horton, Matthew W -- Jarymowycz, Lucien B -- Sperone, F Gianluca -- Toomajian, Chris -- Roux, Fabrice -- Bergelson, Joy -- GM083068/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2011 Oct 7;334(6052):83-6. doi: 10.1126/science.1209244.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21980108" target="_blank"〉PubMed〈/a〉
    Keywords: Acclimatization/*genetics ; Adaptation, Physiological/genetics ; Alleles ; Arabidopsis/*genetics/growth & development/*physiology ; Asia ; *Climate ; Climate Change ; Energy Metabolism ; Europe ; *Genetic Fitness ; Genetic Pleiotropy ; *Genome, Plant ; Genome-Wide Association Study ; Linkage Disequilibrium ; *Polymorphism, Single Nucleotide ; *Selection, Genetic ; Temperature ; Water
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Chronic stress triggers social aversion via glucocorticoid receptor in dopaminoceptive neurons (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-01-19
    Description: Repeated traumatic events induce long-lasting behavioral changes that are key to organism adaptation and that affect cognitive, emotional, and social behaviors. Rodents subjected to repeated instances of aggression develop enduring social aversion and increased anxiety. Such repeated aggressions trigger a stress response, resulting in glucocorticoid release and activation of the ascending dopamine (DA) system. We bred mice with selective inactivation of the gene encoding the glucocorticoid receptor (GR) along the DA pathway, and exposed them to repeated aggressions. GR in dopaminoceptive but not DA-releasing neurons specifically promoted social aversion as well as dopaminergic neurochemical and electrophysiological neuroadaptations. Anxiety and fear memories remained unaffected. Acute inhibition of the activity of DA-releasing neurons fully restored social interaction in socially defeated wild-type mice. Our data suggest a GR-dependent neuronal dichotomy for the regulation of emotional and social behaviors, and clearly implicate GR as a link between stress resiliency and dopaminergic tone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barik, Jacques -- Marti, Fabio -- Morel, Carole -- Fernandez, Sebastian P -- Lanteri, Christophe -- Godeheu, Gerard -- Tassin, Jean-Pol -- Mombereau, Cedric -- Faure, Philippe -- Tronche, Francois -- New York, N.Y. -- Science. 2013 Jan 18;339(6117):332-5. doi: 10.1126/science.1226767.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Genetics, Neurophysiology and Behavior Group, Centre National de la Recherche Scientifique (CNRS) Unite Mixte de Recherche (UMR) 7224, Paris, France. jacques.barik@snv.jussieu.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23329050" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anxiety/*metabolism ; Dopamine/*metabolism ; Dopaminergic Neurons/*metabolism ; Fear ; Mice ; Mice, Mutant Strains ; Receptors, Dopamine/metabolism ; Receptors, Glucocorticoid/genetics/*metabolism ; *Social Alienation ; *Social Isolation ; Stress, Psychological/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Internalization of Salmonella by macrophages induces formation of nonreplicating persisters (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-01-11
    Description: Many bacterial pathogens cause persistent infections despite repeated antibiotic exposure. Bacterial persisters are antibiotic-tolerant cells, but little is known about their growth status and the signals and pathways leading to their formation in infected tissues. We used fluorescent single-cell analysis to identify Salmonella persisters during infection. These were part of a nonreplicating population formed immediately after uptake by macrophages and were induced by vacuolar acidification and nutritional deprivation, conditions that also induce Salmonella virulence gene expression. The majority of 14 toxin-antitoxin modules contributed to intracellular persister formation. Some persisters resumed intracellular growth after phagocytosis by naive macrophages. Thus, the vacuolar environment induces phenotypic heterogeneity, leading to either bacterial replication or the formation of nonreplicating persisters that could provide a reservoir for relapsing infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Helaine, Sophie -- Cheverton, Angela M -- Watson, Kathryn G -- Faure, Laura M -- Matthews, Sophie A -- Holden, David W -- 095484/Wellcome Trust/United Kingdom -- MR/K027077/1/Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2014 Jan 10;343(6167):204-8. doi: 10.1126/science.1244705.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Microbiology, Medical Research Council Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24408438" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Bacterial Agents/pharmacology ; Antitoxins/genetics ; Bacterial Toxins/genetics ; Cefotaxime/pharmacology ; Gene Deletion ; Gene Expression Regulation, Bacterial ; Lymph Nodes/immunology/microbiology ; Macrophages/*microbiology ; Mesentery/immunology/microbiology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Operon/genetics ; Phagocytosis ; Pyrophosphatases/genetics ; Recurrence ; Salmonella Infections/*immunology/*microbiology ; Salmonella typhimurium/drug effects/genetics/*growth & development ; Spleen/immunology/microbiology ; Virulence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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