Publication Date:
2010-02-27
Description:
Legume plants host nitrogen-fixing endosymbiotic Rhizobium bacteria in root nodules. In Medicago truncatula, the bacteria undergo an irreversible (terminal) differentiation mediated by hitherto unidentified plant factors. We demonstrated that these factors are nodule-specific cysteine-rich (NCR) peptides that are targeted to the bacteria and enter the bacterial membrane and cytosol. Obstruction of NCR transport in the dnf1-1 signal peptidase mutant correlated with the absence of terminal bacterial differentiation. On the contrary, ectopic expression of NCRs in legumes devoid of NCRs or challenge of cultured rhizobia with peptides provoked symptoms of terminal differentiation. Because NCRs resemble antimicrobial peptides, our findings reveal a previously unknown innovation of the host plant, which adopts effectors of the innate immune system for symbiosis to manipulate the cell fate of endosymbiotic bacteria.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van de Velde, Willem -- Zehirov, Grigor -- Szatmari, Agnes -- Debreczeny, Monika -- Ishihara, Hironobu -- Kevei, Zoltan -- Farkas, Attila -- Mikulass, Kata -- Nagy, Andrea -- Tiricz, Hilda -- Satiat-Jeunemaitre, Beatrice -- Alunni, Benoit -- Bourge, Mickael -- Kucho, Ken-ichi -- Abe, Mikiko -- Kereszt, Attila -- Maroti, Gergely -- Uchiumi, Toshiki -- Kondorosi, Eva -- Mergaert, Peter -- New York, N.Y. -- Science. 2010 Feb 26;327(5969):1122-6. doi: 10.1126/science.1184057.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut des Sciences du Vegetal, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20185722" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Anti-Bacterial Agents/pharmacology
;
Cell Division
;
Cell Membrane/metabolism
;
Cytosol/metabolism
;
Genes, Plant
;
Lotus/genetics/metabolism/microbiology
;
Medicago truncatula/genetics/*metabolism/*microbiology
;
Molecular Sequence Data
;
Nitrogen Fixation
;
Peptides/chemistry/genetics/*metabolism/pharmacology
;
Plant Proteins/chemistry/genetics/*metabolism
;
Plants, Genetically Modified
;
Protein Transport
;
Root Nodules, Plant/metabolism/microbiology
;
Sinorhizobium meliloti/*cytology/drug effects/*physiology
;
*Symbiosis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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