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  • National Academy of Sciences  (2)
  • Wiley-Blackwell  (2)
  • 2010-2014  (2)
  • 1985-1989  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 19 (1988), S. 67-73 
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Fatigue Life Calculation on the Basis of Fatigue FunctionsSpecific two-step tests constitute the basis of the fatigue functions determination. They consider the fatigue state reached during preloading in the action on the following stress step. The fatigue functions control the sequence of the fatigue life calculation at multi-step and random loadings.
    Notes: Ausgewählte Zweistufenversuche bilden die Grundlage für die Aufstellung von Ermüdungsfunktionen. Sie berücksichtigen den während der schwingenden Vorbelastung erreichten Ermüdungszustand in seiner Auswirkung auf die nachfolgende Belastungsstufe. Die Ermüdungsfunktionen steuern den Ablauf der Berechnung der Lebensdauer bei Mehrstufen- und Randombelastungen.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 20 (1989), S. 187-195 
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Effects of Loading Sequences and Size of Repeated Stress Block of Loads on Fatigue Life Calculated using Fatigue FunctionsIt is well-known that collective form, stress intensity and loading sequence of individual stresses as well as size of repeated stress blocks can influence fatigue life, significantly. The basic variant of the consecutive Wöhler curve concept will permit these effects to be involved into fatigue life computation. The paper presented will demonstrate that fatigue life computations using fatigue functions reflect the loading sequence effect with multilevel loading precisely and provide reliable fatigue life data. Effects of size of repeated stress block and loading sequence on fatigue life as observed with block program tests can be reproduced using the new computation method.
    Notes: Man weiß, daß Kollektivform, Beanspruchungsintensität und Reihenfolge der einzelnen Beanspruchungen sowie der Umfang der periodischen Teilfolgen die Lebensdauer bei Blockprogrammversuchen signifikant beeinflussen können. Die Basisvariante des Folge-Wöhler-Kurven-Konzepts erlaubt die Einbeziehung dieser Einflüsse in die Lebensdauerberechnung. Im vorliegenden Beitrag wird gezeigt, daß die Lebensdauerberechnungen mit Ermüdungsfunktionen den Reihenfolge-Effekt bei Mehrstufenbelastungen richtig widerspiegeln und treffsichere Lebensdauerwerte liefern. Die bei Blockprogrammversuchen beobachteten Einflüsse von Teilfolgeumfang und Reihenfolge auf die Lebensdauer sind mit Hilfe des neuen Berechnungsverfahrens nachvollziehbar.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 3
  • 4
    Publication Date: 2012-02-01
    Description: Plant and metazoan microRNAs (miRNAs) guide ARGONAUTE (AGO) protein complexes to regulate expression of complementary RNAs via base pairing. In the plant Arabidopsis thaliana, the main miRNA effector is AGO1, but few other factors required for miRNA activity are known. Here, we isolate the genes defined by the previously described miRNA action deficient (mad) mutants, mad3 and mad4. Both genes encode enzymes involved in isoprenoid biosynthesis. MAD3 encodes 3-hydroxy-3-methylglutaryl CoA reductase (HMG1), which functions in the initial C5 building block biogenesis that precedes isoprenoid metabolism. HMG1 is a key regulatory enzyme that controls the amounts of isoprenoid end products. MAD4 encodes sterol C-8 isomerase (HYDRA1) that acts downstream in dedicated sterol biosynthesis. Using yeast complementation assays and in planta application of lovastatin, a competitive inhibitor of HMG1, we show that defects in HMG1 catalytic activity are sufficient to inhibit miRNA activity. Many isoprenoid derivatives are indispensable structural and signaling components, and especially sterols are essential membrane constituents. Accordingly, we provide evidence that AGO1 is a peripheral membrane protein. Moreover, specific hypomorphic mutant alleles of AGO1 display compromised membrane association and AGO1-membrane interaction is reduced upon knockdown of HMG1/MAD3. These results suggest a possible basis for the requirement of isoprenoid biosynthesis for the activity of plant miRNAs, and unravel mechanistic features shared with their metazoan counterparts.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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