ALBERT

Description: Brain derived neurotrophic factor (BDNF) is the main activity-dependent neurotrophin in the human nervous system. BDNF is implicated in production of new neurons from dentate gyrus stem cells (hippocampal neurogenesis), synapse formation, sprouting of new axons, growth of new axons, sprouting of new dendrites, and neuron survival. Alterations in the amount or activity of BDNF can produce significant detrimental changes to cortical function and synaptic transmission in the human brain. This can result in glial and neuronal dysfunction, which may contribute to a range of clinical conditions, spanning a number of learning, behavioral, and neurological disorders. There is an extensive body of work surrounding the BDNF molecular network, including BDNF gene polymorphisms, methylated BDNF gene promoters, multiple gene transcripts, varied BDNF functional proteins, and different BDNF receptors (whose activation differentially drive the neuron to neurogenesis or apoptosis). BDNF is also closely linked to mitochondrial biogenesis through PGC-1alpha, which can influence brain and muscle metabolic efficiency. BDNF AS A HUMAN SPACE FLIGHT COUNTERMEASURE TARGET Earth-based studies reveal that BDNF is negatively impacted by many of the conditions encountered in the space environment, including oxidative stress, radiation, psychological stressors, sleep deprivation, and many others. A growing body of work suggests that the BDNF network is responsive to a range of diet, nutrition, exercise, drug, and other types of influences. This section explores the BDNF network in the context of 1) protecting the brain and nervous system in the space environment, 2) optimizing neurobehavioral performance in space, and 3) reducing the residual effects of space flight on the nervous system on return to Earth

Description: This paper presents optical photometry and spectroscopy of SN 1987D, a Type Ia supernova in the nearby galaxy UGC 7370, during the period immediately subsequent to its discovery. The distance modulus of the galaxy, independently determined by the redshift and the Tully-Fisher (1977) relation, is 32.3 + or - 1.0. The maximum brightness of SN 1987D was V about 13.2 and occurred on April 18, 1987, + or - 4 days; the absolute luminosity is about 0.6 mag brighter than the average for SNe Ia. The spectrum of SN 1987D is typical of SNe Ia, but the expansion velocity (9600 km/s) is considerably lower than average.

Description: Using the Einstein Observatory, X-ray observations of about 80 percent of the quasars in the Bright Quasar Survey located outside the declination range defined by 30 and 60 deg. X-ray emission has been detected above the 3-sigma level for 57 out of 66 quasars observed. This paper describes observations and data reduction and provides a summary of the more detailed analyses and discussion contained in the two accompanying papers (Schmidt and Green 1986, Avni and Tananbaum 1986).