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  • Humans  (3)
  • American Association for the Advancement of Science (AAAS)  (3)
  • Springer
  • 2010-2014  (3)
  • 1995-1999
Collection
Keywords
Publisher
Years
  • 2010-2014  (3)
  • 1995-1999
Year
  • 1
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    Measurements of energetic particle radiation in transit to Mars on the Mars Science Laboratory (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-06-01
    Description: The Mars Science Laboratory spacecraft, containing the Curiosity rover, was launched to Mars on 26 November 2011, and for most of the 253-day, 560-million-kilometer cruise to Mars, the Radiation Assessment Detector made detailed measurements of the energetic particle radiation environment inside the spacecraft. These data provide insights into the radiation hazards that would be associated with a human mission to Mars. We report measurements of the radiation dose, dose equivalent, and linear energy transfer spectra. The dose equivalent for even the shortest round-trip with current propulsion systems and comparable shielding is found to be 0.66 +/- 0.12 sievert.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zeitlin, C -- Hassler, D M -- Cucinotta, F A -- Ehresmann, B -- Wimmer-Schweingruber, R F -- Brinza, D E -- Kang, S -- Weigle, G -- Bottcher, S -- Bohm, E -- Burmeister, S -- Guo, J -- Kohler, J -- Martin, C -- Posner, A -- Rafkin, S -- Reitz, G -- New York, N.Y. -- Science. 2013 May 31;340(6136):1080-4. doi: 10.1126/science.1235989.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Southwest Research Institute, Boulder, CO, USA. zeitlin@boulder.swri.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23723233" target="_blank"〉PubMed〈/a〉
    Keywords: *Cosmic Radiation ; Humans ; *Mars ; *Radiation Dosage ; *Space Flight
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Long-acting integrase inhibitor protects macaques from intrarectal simian/human immunodeficiency virus (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-03-07
    Description: GSK1265744 (GSK744) is an integrase strand-transfer inhibitor that has been formulated as a long-acting (LA) injectable suitable for monthly to quarterly clinical administration. GSK744 LA was administered at two time points 4 weeks apart beginning 1 week before virus administration, and macaques were challenged weekly for 8 weeks. GSK744 LA, at plasma concentrations achievable with quarterly injections in humans, protected all animals against repeated low-dose challenges. In a second experiment, macaques were given GSK744 LA 1 week before virus administration and challenged repeatedly until infection occurred. Protection decreased over time and correlated with the plasma drug levels. With a quarterly dosing schedule in humans, our results suggest that GSK744 LA could potentially decrease adherence problems associated with daily preexposure prophylaxis (PrEP).〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308974/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308974/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Andrews, Chasity D -- Spreen, William R -- Mohri, Hiroshi -- Moss, Lee -- Ford, Susan -- Gettie, Agegnehu -- Russell-Lodrigue, Kasi -- Bohm, Rudolf P -- Cheng-Mayer, Cecilia -- Hong, Zhi -- Markowitz, Martin -- Ho, David D -- 1DP1-DA033263/DA/NIDA NIH HHS/ -- 2P51-OD11104-52/OD/NIH HHS/ -- P51 OD011104/OD/NIH HHS/ -- R0-AI100724/AI/NIAID NIH HHS/ -- R01 AI100724/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2014 Mar 7;343(6175):1151-4. doi: 10.1126/science.1248707. Epub 2014 Mar 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Aaron Diamond AIDS Research Center, Rockefeller University, New York, NY 10016, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24594934" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Delayed-Action Preparations/administration & dosage/pharmacokinetics ; HIV Infections/*prevention & control ; HIV Integrase Inhibitors/*administration & dosage/blood/pharmacokinetics ; HIV-1/*drug effects ; Humans ; Macaca mulatta ; Molecular Sequence Data ; Pyridones/*administration & dosage ; Rectum/virology ; Simian Acquired Immunodeficiency Syndrome/*prevention & control ; Simian Immunodeficiency Virus/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Mars' surface radiation environment measured with the Mars Science Laboratory's Curiosity rover (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-12-11
    Description: The Radiation Assessment Detector (RAD) on the Mars Science Laboratory's Curiosity rover began making detailed measurements of the cosmic ray and energetic particle radiation environment on the surface of Mars on 7 August 2012. We report and discuss measurements of the absorbed dose and dose equivalent from galactic cosmic rays and solar energetic particles on the martian surface for ~300 days of observations during the current solar maximum. These measurements provide insight into the radiation hazards associated with a human mission to the surface of Mars and provide an anchor point with which to model the subsurface radiation environment, with implications for microbial survival times of any possible extant or past life, as well as for the preservation of potential organic biosignatures of the ancient martian environment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hassler, Donald M -- Zeitlin, Cary -- Wimmer-Schweingruber, Robert F -- Ehresmann, Bent -- Rafkin, Scot -- Eigenbrode, Jennifer L -- Brinza, David E -- Weigle, Gerald -- Bottcher, Stephan -- Bohm, Eckart -- Burmeister, Soenke -- Guo, Jingnan -- Kohler, Jan -- Martin, Cesar -- Reitz, Guenther -- Cucinotta, Francis A -- Kim, Myung-Hee -- Grinspoon, David -- Bullock, Mark A -- Posner, Arik -- Gomez-Elvira, Javier -- Vasavada, Ashwin -- Grotzinger, John P -- MSL Science Team -- New York, N.Y. -- Science. 2014 Jan 24;343(6169):1244797. doi: 10.1126/science.1244797. Epub 2013 Dec 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Southwest Research Institute, Boulder, CO 80302, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24324275" target="_blank"〉PubMed〈/a〉
    Keywords: *Cosmic Radiation ; Deinococcus/physiology/radiation effects ; *Exobiology ; *Extraterrestrial Environment ; Humans ; *Mars ; Organic Chemicals/analysis ; Radiation Dosage ; Space Flight ; Surface Properties/radiation effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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