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  • Humans  (2)
  • Bone Marrow/pathology/*virology  (1)
  • Halobacteriaceae/genetics  (1)
  • American Association for the Advancement of Science (AAAS)  (2)
  • American Chemical Society
  • American Chemical Society (ACS)
  • 2010-2014  (1)
  • 1995-1999  (1)
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Keywords
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  • American Association for the Advancement of Science (AAAS)  (2)
  • American Chemical Society
  • American Chemical Society (ACS)
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Year
  • 1
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    Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-06-26
    Description: Retinitis pigmentosa refers to a diverse group of hereditary diseases that lead to incurable blindness, affecting two million people worldwide. As a common pathology, rod photoreceptors die early, whereas light-insensitive, morphologically altered cone photoreceptors persist longer. It is unknown if these cones are accessible for therapeutic intervention. Here, we show that expression of archaebacterial halorhodopsin in light-insensitive cones can substitute for the native phototransduction cascade and restore light sensitivity in mouse models of retinitis pigmentosa. Resensitized photoreceptors activate all retinal cone pathways, drive sophisticated retinal circuit functions (including directional selectivity), activate cortical circuits, and mediate visually guided behaviors. Using human ex vivo retinas, we show that halorhodopsin can reactivate light-insensitive human photoreceptors. Finally, we identified blind patients with persisting, light-insensitive cones for potential halorhodopsin-based therapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Busskamp, Volker -- Duebel, Jens -- Balya, David -- Fradot, Mathias -- Viney, Tim James -- Siegert, Sandra -- Groner, Anna C -- Cabuy, Erik -- Forster, Valerie -- Seeliger, Mathias -- Biel, Martin -- Humphries, Peter -- Paques, Michel -- Mohand-Said, Saddek -- Trono, Didier -- Deisseroth, Karl -- Sahel, Jose A -- Picaud, Serge -- Roska, Botond -- New York, N.Y. -- Science. 2010 Jul 23;329(5990):413-7. doi: 10.1126/science.1190897. Epub 2010 Jun 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20576849" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dependovirus/genetics ; Disease Models, Animal ; Evoked Potentials, Visual ; *Genetic Therapy ; Genetic Vectors ; Halobacteriaceae/genetics ; Halorhodopsins/*genetics/*metabolism ; Humans ; Light ; Mice ; Mice, Knockout ; Promoter Regions, Genetic ; Retina/physiology ; Retinal Cone Photoreceptor Cells/*physiology ; Retinal Ganglion Cells/physiology ; Retinitis Pigmentosa/physiopathology/*therapy ; Tissue Culture Techniques ; Transfection ; Vision, Ocular ; Visual Pathways/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-06-20
    Description: Kaposi's sarcoma-associated herpesvirus (KSHV) was found in the bone marrow dendritic cells of multiple myeloma patients but not in malignant plasma cells or bone marrow dendritic cells from normal individuals or patients with other malignancies. In addition the virus was detected in the bone marrow dendritic cells from two out of eight patients with monoclonal gammopathy of undetermined significance (MGUS), a precursor to myeloma. Viral interleukin-6, the human homolog of which is a growth factor for myeloma, was found to be transcribed in the myeloma bone marrow dendritic cells. KSHV may be required for transformation from MGUS to myeloma and perpetuate the growth of malignant plasma cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rettig, M B -- Ma, H J -- Vescio, R A -- Pold, M -- Schiller, G -- Belson, D -- Savage, A -- Nishikubo, C -- Wu, C -- Fraser, J -- Said, J W -- Berenson, J R -- New York, N.Y. -- Science. 1997 Jun 20;276(5320):1851-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Hematology and Oncology, Veterans Affairs West Los Angeles Medical Center, Los Angeles, CA 90073, USA. RETTIG.MATTHEW@WEST-LA.VA.GOV〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9188529" target="_blank"〉PubMed〈/a〉
    Keywords: Blotting, Southern ; Bone Marrow/pathology/*virology ; Cell Transformation, Neoplastic ; DNA, Viral/analysis ; Dendritic Cells/*virology ; HL-60 Cells ; Herpesvirus 8, Human/genetics/isolation & purification/*pathogenicity/physiology ; Humans ; In Situ Hybridization ; Interleukin-6/*analysis/genetics/physiology ; Multiple Myeloma/pathology/*virology ; Paraproteinemias/pathology/virology ; Polymerase Chain Reaction ; Stromal Cells/pathology/virology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
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