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Combination therapy targeting ectopic ATP synthase and 26S proteasome induces ER stress in breast cancer cells (2014)

H-Y Chang; T-C Huang; N-N Chen; H-C Huang; H-F Juan

Springer Nature

In: Cell Death & Disease

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Publikationsdatum: 2014-11-28

Beschreibung: Combination therapy targeting ectopic ATP synthase and 26S proteasome induces ER stress in breast cancer cells Cell Death and Disease 5, e1540 (November 2014). doi:10.1038/cddis.2014.504 Authors: H-Y Chang, T-C Huang, N-N Chen, H-C Huang & H-F Juan

Digitale ISSN: 2041-4889

Thema: Biologie , Medizin

Publiziert von Springer Nature

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Wentilactone B induces G2/M phase arrest and apoptosis via the Ras/Raf/MAPK signaling pathway in human hepatoma SMMC-7721 cells (2013)

Z Zhang; L Miao; C Lv; H Sun; S Wei; B Wang; C Huang; B Jiao

Springer Nature

In: Cell Death & Disease

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Publikationsdatum: 2013-06-07

Beschreibung: Wentilactone B induces G2/M phase arrest and apoptosis via the Ras/Raf/MAPK signaling pathway in human hepatoma SMMC-7721 cells Cell Death and Disease 4, e657 (June 2013). doi:10.1038/cddis.2013.182 Authors: Z Zhang, L Miao, C Lv, H Sun, S Wei, B Wang, C Huang & B Jiao

Schlagwort(e): Wentilactone BSMMC-7721 cellscell cycle arrestapoptosisMAPK pathway

Digitale ISSN: 2041-4889

Thema: Biologie , Medizin

Publiziert von Springer Nature

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3

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Nonlinear Analysis and Intelligent Control of Integrated Vehicle Dynamics (2014)

C. Huang, L. Chen, H. B. Jiang, C. C. Yuan, and T. Xia

Hindawi

In: Mathematical Problems in Engineering

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Publikationsdatum: 2014-01-22

Beschreibung: With increasing and more stringent requirements for advanced vehicle integration, including vehicle dynamics and control, traditional control and optimization strategies may not qualify for many applications. This is because, among other factors, they do not consider the nonlinear characteristics of practical systems. Moreover, the vehicle wheel model has some inadequacies regarding the sideslip angle, road adhesion coefficient, vertical load, and velocity. In this paper, an adaptive neural wheel network is introduced, and the interaction between the lateral and vertical dynamics of the vehicle is analyzed. By means of nonlinear analyses such as the use of a bifurcation diagram and the Lyapunov exponent, the vehicle is shown to exhibit complicated motions with increasing forward speed. Furthermore, electric power steering (EPS) and active suspension system (ASS), which are based on intelligent control, are used to reduce the nonlinear effect, and a negotiation algorithm is designed to manage the interdependences and conflicts among handling stability, driving smoothness, and safety. Further, a rapid control prototype was built using the hardware-in-the-loop simulation platform dSPACE and used to conduct a real vehicle test. The results of the test were consistent with those of the simulation, thereby validating the proposed control.

Print ISSN: 1024-123X

Digitale ISSN: 1563-5147

Thema: Mathematik , Technik allgemein

Publiziert von Hindawi

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4

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Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells, and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway (2013)

C Lv; Y Hong; L Miao; C Li; G Xu; S Wei; B Wang; C Huang; B Jiao

Springer Nature

In: Cell Death & Disease

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Publikationsdatum: 2013-12-06

Beschreibung: Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells, and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway Cell Death and Disease 4, e952 (December 2013). doi:10.1038/cddis.2013.484 Authors: C Lv, Y Hong, L Miao, C Li, G Xu, S Wei, B Wang, C Huang & B Jiao

Schlagwort(e): Wentilactone Anovel antitumor agentlung cancerRas/Raf/ERK/p53-p21 pathway

Digitale ISSN: 2041-4889

Thema: Biologie , Medizin

Publiziert von Springer Nature

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Tuning the band structure and superconductivity in single-layer FeSe by interface engineering (2014)

R. Peng; H. C. Xu; S. Y. Tan; H. Y. Cao; M. Xia; X. P. Shen; Z. C. Huang; C.H.P. Wen; Q. Song; T. Zhang; B. P. Xie; X. G. Gong; D. L. Feng

Springer Nature

In: Nature Communications

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Publikationsdatum: 2014-09-28

Beschreibung: Article Individual layers of FeSe grown on SrTiO3 superconduct at far higher temperatures than in bulk, but the effect of the film-substrate interface is poorly understood. Peng et al . find that modifying this interface has a significant non-trivial effect on the superconducting characteristics of FeSe films. Nature Communications doi: 10.1038/ncomms6044 Authors: R. Peng, H. C. Xu, S. Y. Tan, H. Y. Cao, M. Xia, X. P. Shen, Z. C. Huang, C.H.P. Wen, Q. Song, T. Zhang, B. P. Xie, X. G. Gong, D. L. Feng

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma (2013)

C-W Tsai; F-J Lai; H-M Sheu; Y-S Lin; T-H Chang; M-S Jan; S-M Chen; P-C Hsu; T-T Huang; T-C Huang; M-C Sheen; S-T Chen; W-C Chang; N-S Chang; L-J Hsu

Springer Nature

In: Cell Death & Disease

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Publikationsdatum: 2013-09-06

Beschreibung: WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma Cell Death and Disease 4, e792 (September 2013). doi:10.1038/cddis.2013.308 Authors: C-W Tsai, F-J Lai, H-M Sheu, Y-S Lin, T-H Chang, M-S Jan, S-M Chen, P-C Hsu, T-T Huang, T-C Huang, M-C Sheen, S-T Chen, W-C Chang, N-S Chang & L-J Hsu

Schlagwort(e): tumor suppressormethotrexatechemotherapyautophagyapoptosis

Digitale ISSN: 2041-4889

Thema: Biologie , Medizin

Publiziert von Springer Nature

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7

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The N-terminal region of p27 inhibits HIF-1α protein translation in ribosomal protein S6-dependent manner by regulating PHLPP-Ras-ERK-p90RSK axis (2014)

D Zhang; J Liu; X Mi; Y Liang; J Li; C Huang

Springer Nature

In: Cell Death & Disease

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Publikationsdatum: 2014-11-21

Beschreibung: The N-terminal region of p27 inhibits HIF-1α protein translation in ribosomal protein S6-dependent manner by regulating PHLPP-Ras-ERK-p90RSK axis Cell Death and Disease 5, e1535 (November 2014). doi:10.1038/cddis.2014.496 Authors: D Zhang, J Liu, X Mi, Y Liang, J Li & C Huang

Digitale ISSN: 2041-4889

Thema: Biologie , Medizin

Publiziert von Springer Nature

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8

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Multiple-step melting in two-dimensional hexatic liquid-crystal films (1998)

C. F. Chou ; A. J. Jin ; S. W. Hui ; [weitere]

American Association for the Advancement of Science (AAAS)

In: Science. 280(5368): 1424-6.

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Publikationsdatum: 1998-06-05

Beschreibung: An unexpected three-stage melting transition has been observed in two-dimensional (2D) free-standing liquid-crystal films by in situ electron-diffraction and optical-reflectivity measurements. These data suggest the existence of two phases between the 2D solid and liquid: a hexatic phase and, at a higher temperature, an intermediate liquid phase with hexatic-like positional correlations ( approximately 40 angstroms) but no long-range orientational order. Previous high-resolution heat-capacity measurements have revealed a divergent-like anomaly at the hexatic-liquid transition that sharply contradicts the predictions of 2D melting theories. The observation of an intermediate isotropic phase may alter our understanding of 2D melting and lead to reconciliation between current experiments and theories.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chou -- Jin -- Hui -- Huang -- Ho -- New York, N.Y. -- Science. 1998 May 29;280(5368):1424-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉C.-F. Chou, Department of Physics, Princeton University, Princeton, NJ 08544, USA. A. J. Jin, Applied Materials, 3320 Scott Boulevard, Mailstop 1114, Santa Clara, CA 95054, USA. S. W. Hui, Department of Biophysics, Roswell Park Cancer Institute, Buf.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9603729" target="_blank"〉PubMed〈/a〉

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

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9

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity (1999)

P. Bouillet ; D. Metcalf ; D. C. Huang ; [weitere]

American Association for the Advancement of Science (AAAS)

In: Science. 286(5445): 1735-8.

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Publikationsdatum: 1999-11-27

Beschreibung: Apoptosis can be triggered by members of the Bcl-2 protein family, such as Bim, that share only the BH3 domain with this family. Gene targeting in mice revealed important physiological roles for Bim. Lymphoid and myeloid cells accumulated, T cell development was perturbed, and most older mice accumulated plasma cells and succumbed to autoimmune kidney disease. Lymphocytes were refractory to apoptotic stimuli such as cytokine deprivation, calcium ion flux, and microtubule perturbation but not to others. Thus, Bim is required for hematopoietic homeostasis and as a barrier to autoimmunity. Moreover, particular death stimuli appear to activate apoptosis through distinct BH3-only proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bouillet, P -- Metcalf, D -- Huang, D C -- Tarlinton, D M -- Kay, T W -- Kontgen, F -- Adams, J M -- Strasser, A -- CA43540/CA/NCI NIH HHS/ -- CA80188/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1999 Nov 26;286(5445):1735-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10576740" target="_blank"〉PubMed〈/a〉

Schlagwort(e): Animals ; *Apoptosis ; Apoptosis Regulatory Proteins ; Autoimmune Diseases/etiology ; *Autoimmunity ; B-Lymphocytes/physiology ; Carrier Proteins/*physiology ; Cells, Cultured ; Crosses, Genetic ; Female ; Gene Targeting ; Glomerulonephritis/etiology ; Hematopoietic Stem Cells/physiology ; Homeostasis ; Leukocyte Count ; Leukocytes/*physiology ; Male ; *Membrane Proteins ; Mice ; Mice, Transgenic ; *Proto-Oncogene Proteins ; Proto-Oncogene Proteins c-bcl-2/physiology ; Signal Transduction ; T-Lymphocyte Subsets/physiology

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

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10

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Partitioning of histone H3-H4 tetramers during DNA replication-dependent chromatin assembly (2010)

M. Xu ; C. Long ; X. Chen ; [weitere]

American Association for the Advancement of Science (AAAS)

In: Science. 328(5974): 94-8. doi: 10.1126/science.1178994.

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Publikationsdatum: 2010-04-03

Beschreibung: Semiconservative DNA replication ensures the faithful duplication of genetic information during cell divisions. However, how epigenetic information carried by histone modifications propagates through mitotic divisions remains elusive. To address this question, the DNA replication-dependent nucleosome partition pattern must be clarified. Here, we report significant amounts of H3.3-H4 tetramers split in vivo, whereas most H3.1-H4 tetramers remained intact. Inhibiting DNA replication-dependent deposition greatly reduced the level of splitting events, which suggests that (i) the replication-independent H3.3 deposition pathway proceeds largely by cooperatively incorporating two new H3.3-H4 dimers and (ii) the majority of splitting events occurred during replication-dependent deposition. Our results support the idea that "silent" histone modifications within large heterochromatic regions are maintained by copying modifications from neighboring preexisting histones without the need for H3-H4 splitting events.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xu, Mo -- Long, Chengzu -- Chen, Xiuzhen -- Huang, Chang -- Chen, She -- Zhu, Bing -- New York, N.Y. -- Science. 2010 Apr 2;328(5974):94-8. doi: 10.1126/science.1178994.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Graduate Program, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, People's Republic of China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20360108" target="_blank"〉PubMed〈/a〉

Schlagwort(e): Amino Acid Sequence ; Aphidicolin/pharmacology ; Cell Cycle ; Chromatin/metabolism ; *Chromatin Assembly and Disassembly ; *DNA Replication ; Epigenesis, Genetic ; HeLa Cells ; Heterochromatin/metabolism ; Histones/*chemistry/*metabolism ; Humans ; Hydroxyurea/pharmacology ; Mass Spectrometry ; Molecular Sequence Data ; Nucleosomes/*metabolism ; Protein Multimerization ; S Phase ; Transfection

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

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