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  • nitrogen  (47)
  • pharmacokinetics  (31)
  • temperature  (31)
  • Q1-390
  • Springer  (109)
  • American Association of Petroleum Geologists
  • Frontiers Media SA
  • Institute of Physics
  • Wiley
  • 2010-2014
  • 1995-1999  (109)
  • 1920-1924
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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of 5-aminosalicylic acid from controlled-release capsules in man (1995)
    Springer
    European journal of clinical pharmacology 48 (1995), S. 273-277 
    Details
    ISSN: 1432-1041
    Keywords: Mesalamine ; 5-aminosalicylic acid ; controlled release capsules ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract One gram single dose of Pentasa controlled-release capsules was administered to 24 healthy volunteers under fasting condition. Mean plasma 5-aminosalicylic acid (5-ASA) and acetyl 5-ASA concentrations peaked at 0.53 μg · ml−1 and 1.33 μg · ml−1 from 3 to 4 hours following dosing, respectively. The half-lives of both compounds could not be determined as absorption of 5-ASA was continuous throughout the gastrointestinal tract. An average of 29.4% (CV: 27%) of the dose was excreted in the urine primarily as acetyl 5-ASA. Up to 91.1% of the dose was released from the capsules. Forty percent of the dose (CV: 40%) was eliminated in the feces, with 8.9% of the dose remained as formulation bounded 5-ASA, indicating that controlled-release capsules continue to release drug throughout the GI tract. 5-ASA contributed 46.7% of the salicylates eliminated in the feces and acetyl 5-ASA accounted for the balance. Controlled-release capsules produced three times more total salicylates and 10 times more total and free 5-ASA in the feces than did 5-ASA suspension. Thus, while lower systemic levels of salicylates were absorbed, greater therapeutic quantities of 5-ASA were available in the bowel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00198311
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  • 2
    Electronic Resource
    Electronic Resource
    Relationships between soluble sugar concentrations in roots and ecosystem stress for first year sugar maple seedlings (1996)
    Springer
    Water, air & soil pollution 88 (1996), S. 1-19 
    Details
    ISSN: 1573-2932
    Keywords: Acidic deposition ; vesicular-arbuscular mycorrhizae ; seedling nutrition ; temperature
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Accumulation of reducing sugars (i.e., glucose and fructose) in plant roots has been consistently correlated with forest dieback and decline and, therefore, has potential as a biological indicator of ecosystem stress. In this study, the relationships between acidic deposition and “natural” (temperature, mycorrhizae, and nutrition) factors with first-year sugar maple seedling root sugar concentrations and growth were assessed in two sugar maple dominated forests in Michigan. Seedlings at the southern site (Wellston) had greater root growth, phosphorus, total sugar, and sucrose concentrations in roots, but lower reducing sugar concentration in roots. In addition, percent root length colonized by vesicular-arbuscular mycorrhizal fungi was less than that found for seedlings growing at the northern site (Alberta). Throughfall deposition of nitrate, sulfate, and hydrogen ions was not significantly correlated with seedling total or reducing sugar concentration. Total sugar concentration in seedling roots was positively correlated with air and soil temperatures at the southern site, but not at the northern site. Seedling tissue phosphorus concentration was correlated with total sugars at both sites, with sucrose at the southern site, and reducing sugars at the northern site. Mycorrhizal colonization rates at the Alberta site were positively correlated with reducing sugar concentration in seedling roots and negatively correlated with sucrose concentration. The results suggest that differences in seedling root sugar concentrations in these two forests are related to seedling root growth and are most likely due to ecological variables, such as available soil phosphorus, temperature, and growing season length through some complex interaction with mycorrhizae rather than acidic deposition stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00157410
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  • 3
    Electronic Resource
    Electronic Resource
    Monitoring nitrogen pollution from sugarcane runoff using15N analysis (1997)
    Springer
    Water, air & soil pollution 98 (1997), S. 389-399 
    Details
    ISSN: 1573-2932
    Keywords: fertilizer ; nitrogen ; pollution ; runoff ; stable isotopes ; sugarcane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract In many forested wetlands of Louisiana, surface water quality is being deteriorated by nutrient input from adjacent agricultural production area. This field study assesses the input of fertilizer N, applied to sugarcane fields, to forested wetlands. The potential use of natural abundance variations in15N/14N ratios for identification and tracing surface water N sources (NH 4 + - and NO 3 − -N) was evaluated. Runoff and surface water samples were collected from sugarcane fields and bordering forested wetlands (6 stations) over a 16 month period and analyzed for NH 4 + -N, NO 3 − -N, and associated NH 4 + -δ 15N and NO 3 − -δ 15N ratios. FertilizerN draining into adjacent forested wetland was estimated to be only a small fraction of the amount applied. Concentrations of NH 4 + - and NO 3 − -N in the collected water samples were low and ranged from 0.02 to 1.79 mg L−1. Isotopic analysis revealed NH 4 + -δ 15N and NO 3 − -δ 15N means were distinctive and may have the potential to be used as tracers of N contamination. The mean NH 4 + -δ 15N value was +18.6±7.1‰ and the NO 3 − -δ 15N mean was +8.3±3.1‰. Anomalously high NO 3 − -δ 15N values (〉30‰) were attributed to denitrification.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02047046
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  • 4
    Electronic Resource
    Electronic Resource
    Pharmacokinetic and phase I studies of brequinar (DUP 785; NSC 368390) in combination with cisplatin in patients with advanced malignancies (1998)
    Springer
    Investigational new drugs 16 (1998), S. 19-27 
    Details
    ISSN: 1573-0646
    Keywords: phase I ; brequinar ; DUP 785 ; cisplatin ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Brequinar (DUP 785; NSC 368390) is a quinoline carboxylic acid derivative that inhibits pyrimidine synthesis at the level of dihydro-orotate dehydrogenase and revealed synergy with cisplatin in preclinical models. In this study investigating the pharmacokinetic and toxicity of brequinar in combination with cisplatin, patients were initially treated with weekly brequinar, in combination with an every-three-week administration of cisplatin. Due to toxicity, the schedule was modified to a 28-day cycle with brequinar given on days 1, 8, 15, and cisplatin on day 1. A total of 24 patients (16 male, 8 female; median age 57; median performance status 1) received 69 courses of therapy. Six dose levels were explored, with cisplatin/ brequinar doses, respectively, of 50/500, 50/650, 50/860, 60/860, 75/650, and 75/860 mg/m2. The serum concentration versus time curves for brequinar were biphasic. A comparison of the pharmacokinetic results after the first and third doses of brequinar indicate that the presence of 50, 60, and 75 mg/m2cisplatin did not change the protein binding and the pharmacokinetics of brequinar in any of the three brequinar-dose groups. Total cisplatin plasma pharmacokinetic followed a triphasic-shape curve and unbound cisplatin decayed at a very rapid rate. Since pharmacokinetic parameters for total cisplatin in this study were similar to those reported in the literature, the presence of brequinar is unlikely to alter the pharmacokinetics of cisplatin. Main dose-limiting toxicities included myelosuppression (including neutropenia and thrombocytopenia) and mucositis. Cisplatin/brequinar doses of 50/500, 50/650, 50/860, 60/860, 75/650, and 75/860 mg/m2, were associated with dose limiting toxicity in 0/3, 1/3, 1/3, 1/3, 2/4, 2/5, and 4/6 patients, respectively. This study shows that co-administration of brequinar and cisplatin does not affect the pharmacokinetic properties of either drug and that the MTDs of cisplatin/brequinar combinations are 60/860 mg/m2 or 75/650 mg/m2. From this study, we conclude that full dose of 75 mg/m2 cisplatin (day 1) can be administered with 650 mg/m2 brequinar (days 1, 8 and 15) without significant modifications of individual drug pharmacokinetic parameters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016066529642
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  • 5
    Electronic Resource
    Electronic Resource
    Transcript accumulation and utilization of alternate and non-consensus splice sites in rice granule-bound starch synthase are temperature-sensitive and controlled by a single-nucleotide polymorphism (1999)
    Springer
    Plant molecular biology 40 (1999), S. 719-727 
    Details
    ISSN: 1573-5028
    Keywords: amylose ; splicing ; starch synthase ; temperature ; waxy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Granule-bound starch synthase (GBSS), a product of the waxy gene in rice (Oryza sativa L.), is necessary for the synthesis of amylose in the endosperm. In an extended pedigree of 89 rice cultivars, we have previously shown that all cultivars with more than 18% amylose had the sequence AGGTATA at the leader intron 5′ splice site, while all cultivars with a lower proportion of amylose had the sequence AGTTATA. This single-nucleotide polymorphism reduces the efficiency of GBSS pre-mRNA processing. It also results in alternate splicing at multiple sites, some of which have non-consensus sequences. Here we demonstrate that this same G-to-T polymorphism is also associated with differential sensitivity to temperature during the period of grain development. Cultivars with the sequence AGTTATA have a substantial increase in accumulation of mature GBSS transcripts at 18 °C compared to 25 or 32 °C. The selection of leader intron 5′ splice sites is also affected by temperature in these cultivars. A 5′ splice site −93 upstream from that used in high-amylose varieties predominates at 18 °C. At higher temperatures there is increased utilization of a 5′ splice site at −1 and a non-consensus site at +1. Potential implications of differential 5′ splice site selection and associated differences in 3′ splice site selection on transcript stability and translational efficiency are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006298608408
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  • 6
    Electronic Resource
    Electronic Resource
    The fate of NH4NO3 added toSphagnum magettanicum carpets at five European mire sites (1999)
    Springer
    Biogeochemistry 45 (1999), S. 73-93 
    Details
    ISSN: 1573-515X
    Keywords: atmospheric deposition ; moss ; bog ; nitrogen ; phosphorus ; water table
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Geosciences
    Notes: Abstract Nitrogen additions as NH4NO3 corresponding to 0 (N0), 1 (N1), 3 (N3) and 10 (N10) g N m−2 yr−1 were made toSphagnum magellanicurn cores at two-week intervalsin situ at four sites across Europe, i.e. Lakkasuo (Finland). Männikjärve (Estonia), Moidach More (UK) and Côte de Braveix (France). The same treatments were applied in a glasshouse experiment in Neuchâtel (Switzerland) in which the water table depth was artificially maintained at 7, 17 and 37 cm below the moss surface. In the field, N assimilation in excess of values in wet deposition occurred in the absence of growth, but varied widely between sites, being absent in Lakkasuo (moss N∶P ratio 68) and greatest in Moidach More (N∶P 21). In the glasshouse, growth was reduced by lowering the water table without any apparent effect on N assimilation. Total N content of the moss in field sites increased as the mean depth of water table increased indicating growth limitation leading to increased N concentrations which could reduce the capacity for N retention. Greater contents of NH4 + in the underlying peat at 30 cm depth, both in response to NH4NO3 addition and in the unamended cores confirmed poor retention of inorganic N by the moss at Lakkasuo. Nitrate contents in the profiles at Lakkasuo, Moidach More, and Côte de Braveix were extremely low, even in the N10 treatment, but in Männikjärve, where the mean depth of water table was greatest and retention absent, appreciable amounts of NO3 − were detected in all cores. It is concluded that peatland drainage would reduce the capture of inorganic N in atmospheric deposition bySphagnum mosses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00992874
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  • 7
    Electronic Resource
    Electronic Resource
    Long term 15N studies in a catena of the shortgrass steppe (1996)
    Springer
    Biogeochemistry 32 (1996), S. 41-52 
    Details
    ISSN: 1573-515X
    Keywords: nitrogen ; particulate organic matter ; nutrient cycling ; grassland
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Geosciences
    Notes: Abstract A set of long term15N studies was initiated during the summers of 1981 and 1982 on the backslope and footslope, respectively, of a catena in the shortgrass steppe of northeastern Colorado. Microplots labeled with15N urea were sampled for15N and total N content in 1981 and 1982 and again in 1992. In November, 1982, 100% of the added N was recovered in the soil-plant system of the finer-textured footslope, compared to 39% in the coarser-textured backslope microplots. Ten years later,15N recovery of the applied N decreased at both topographic positions to 85% in the footslope and 29% in the backslope. Average losses since the time of application were 3.5 g N m−2yr−1 in the backslope and 0.8 g N m−2yr−1 in the footslope. In 1992, soil organic matter was physically fractionated into particulate (POM) and mineral associated (MAON) fractions and 21-day mineralization incubations were conducted to assess the relative amounts of15N that were in the slow, passive and active soil organic matter pools, respectively, of the two soils. Our findings confirm the assumptions that POM represents a large portion of the slow organic compartment and that the MAON represents a large fraction of the passive compartment defined in the Century model. The N located in the MAON had the lowest availability for plant uptake. Isotopic data were consistent with textural effects and with the Century model compartmentalization of soil organic N based on the residence time of the organic N.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00001531
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  • 8
    Electronic Resource
    Electronic Resource
    MONITORING NITROGEN POLLUTION FROM SUGARCANE RUNOFF USING 15N ANALYSIS (1997)
    Springer
    Water, air & soil pollution 98 (1997), S. 389-399 
    Details
    ISSN: 1573-2932
    Keywords: fertilizer ; nitrogen ; pollution ; runoff ; stable isotopes ; sugarcane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract In many forested wetlands of Louisiana, surface water quality is being deteriorated by nutrient input from adjacent agricultural production areas. This field study assesses the input of fertilizer N, applied to sugarcane fields, to forested wetlands. The potential use of natural abundance variations in 15N14N ratios for identification and tracing surface water N sources (NH 4 + - and NO3 --N) was evaluated. Runoff and surface water samples were collected from sugarcane fields and bordering forested wetlands (6 stations) over a 16 month period and analyzed for NH 4 + -N, NO 3 - -N, and associated NH 4 + -δ15N and NO 3 - -δ15N ratios. Fertilizer N draining into adjacent forested wetland was estimated to be only a small fraction of the amount applied. Concentrations of NH 4 + - and NO 3 - -N in the collected water samples were low and ranged from 0.02 to 1.79 mg L-1. Isotopic analysis revealed NH 4 + -δ15N and NO 3 - -δ15N means were distinctive and may have the potential to be used as tracers of N contamination. The mean NH 4 + -δ15N value was +18.6 ± 7.1‰ and the NO 3 - -δ15N mean was +8.3 ± 3.1‰. Anomalously high NO 3 - -δ15N values (〉30‰) were attributed to denitrification.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026483228623
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  • 9
    Electronic Resource
    Electronic Resource
    Effects of Nitrogen and Phosphorus Supply on Hexadecane Biodegradation in Soil Systems (1999)
    Springer
    Water, air & soil pollution 111 (1999), S. 1-18 
    Details
    ISSN: 1573-2932
    Keywords: biodegradation ; hydrocarbon ; nitrogen ; nutrient ratios ; phosphorus ; soils
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The biodegradation of hexadecane (C as hexadecane-C) was assessed under 34 different external nitrogen (N supplied as NO3-N) and phosphorus (P supplied as PO4-3-P) supply conditions in order to determine how different nutrient formulations affected nutrient limitation conditions during degradation. CO2 production yields indicated that shifts in N and P supply levels resulted in variable biodegradation responses due to shifts in the limiting-nutrient (e.g., from N to P). For example, the estimated maximum fractional CO2 yield ratio was 0.24 (mg CO2-C produced mg-1 hexadecane-C) for P-limited nutrient formulations (P:hexadecane-C〈0.01), whereas the yield ratio was more than two times greater when the system was not P- limited. Similar effects were observed for N-limited (N:hexadecane- C〈0.15) versus non-N-limited formulations. The relative bioavailability of natural soil-N and soil-P also was examined. In the soil studied, background soil-N was 96.3% organic-N and was found to be largely nonbioavailable. In contrast, high CO2 yields were observed even when no external P was supplied. An iterative mathematical procedure indicated that the Olsen soil-P subfraction (inorganic soil-P plus soluble organic soil- P) best approximated bioavailable soil-P for this soil. Our results indicate that both N and P additions affect biodegradation yields, but that stoichiometrically inappropriate nutrient mixes produce suboptimal CO2 yields. We also found that the bioavailable fractions of soil-N and soil-P should be incorporated into estimating the most suitable nutrient formulations for a given contamination scenario.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005091427942
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  • 10
    Electronic Resource
    Electronic Resource
    Non-reciprocal cross-incompatibility in Trichogramma deion (1996)
    Springer
    Entomologia experimentalis et applicata 80 (1996), S. 481-489 
    Details
    ISSN: 1570-7458
    Keywords: reproductive compatibility ; hybrid inviability ; temperature ; Trichogramma ; biological control ; Hymenoptera ; Trichogrammatidae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In non-reciprocal cross-incompatibility (NRCI), the crossing of a female of a strain A with a male of a strain B results in hybrid offspring, whereas the reciprocal cross produces few or no hybrids. Only females are of hybrid origin in Hymenoptera because they arise from fertilized eggs; males arise from unfertilized (haploid) eggs. Crosses between many strains of Trichogramma deion showed some degree of NRCI. Crosses between a T. deion culture collected in Seven Pines, California (SVP) with one from Marysville, California (MRY) showed an extreme form of NRCI in which practically no female offspring was produced when MRY females were crossed with SVP males. The reciprocal cross produced a close to normal proportion of female and male offspring. Detailed studied of this cross indicated that 1) the female offspring produced in the compatible interstrain cross were not the result of parthenogenesis but were true hybrids, 2) the incompatible interstrain cross did not produce female offspring because fertilized eggs died during development, 3) the death of these eggs could not be prevented by either antibiotic or temperature treatment, 4) cytoplasmically inherited factors causing NRCI could be discounted because backcrossed females with the genome of MRY and the cytoplasm of SVP, exhibit the NRCI relationship characteristic of their genome. Therefore the NRCI between these strains appears to be caused by a modification coded for by the nuclear genes of MRY that results in incompatibility when SVP sperm fertilizes MRY eggs. In addition the level of incompatibility in crosses between the SVP females and MRY males is temperature sensitive, the higher the rearing temperature the lower the level of compatibility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00343472
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