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  • Articles  (37)
  • American Meteorological Society  (19)
  • American Geophysical Union  (9)
  • American Institute of Physics (AIP)  (5)
  • American Society of Hematology  (4)
  • 2010-2014  (11)
  • 1995-1999  (14)
  • 1990-1994  (11)
  • 1965-1969  (1)
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  • Articles  (37)
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  • 1
    Electronic Resource
    Electronic Resource
    Necessary and sufficient conditions for constructing orthonormal wavelet bases (1991)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 32 (1991), S. 57-61 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: This paper proves a previous conjecture of the author characterizing sequences h∈l2(Z) that yield orthonormal wavelet bases of L2(R) in terms of the multiplicity of the eigenvalue 1 of an operator associated to h. The proof utilizes a result of Cohen characterizing these sequences in terms of the real zeros of their Fourier transforms. The mapping from sequences to wavelets is shown to define a continuous mapping from a subset of l2(Z) into L2(R). Related conjectures are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.529093
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Tight frames of compactly supported affine wavelets (1990)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 31 (1990), S. 1898-1901 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: This paper extends the class of orthonormal bases of compactly supported wavelets recently constructed by Daubechies [Commun. Pure Appl. Math. 41, 909 (1988)]. For each integer N≥1, a family of wavelet functions ψ having support [0,2N−1] is constructed such that {ψjk(x)=2j/2ψ(2jx−k) kj,k∈Z} is a tight frame of L2(R), i.e., for every f∈L2(R), f=c∑jk 〈ψjk||f〉ψjk for some c〉0. This family is parametrized by an algebraic subset VN of R4N. Furthermore, for N≥2, a proper algebraic subset WN of VN is specified such that all points in VN outside of WN yield orthonormal bases. The relationship between these tight frames and the theory of group representations and coherent states is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.528688
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  • 3
    Electronic Resource
    Electronic Resource
    Multiresolution properties of the wavelet Galerkin operator (1991)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 32 (1991), S. 1440-1443 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: This paper extends recent results by the author [J. Math. Phys. 31, 1898 (1990), J. Math. Phys. 32, 57 (1991)] that show a scaling parameter sequence h yields an orthonormal wavelet basis for L2(R) if and only if an associated operator Sh has eigenvalue 1 with multiplicity 1. The operator transforms a sequence a by Sh(a)(k)=2Σm,n∼(h(m))h(n)a(2k+m−n). A correspondence is derived between Sh and Galerkin projection operators related to the multiresolution analysis defined by the orthonormal wavelet basis. The spectrum of Sh is characterized in terms of the Fourier modulus of the (unique) scaling function φ that satisfies φ(x)=2Σnh(n)φ(2x−n). This characterization yields several results including a direct, alternate proof that the eigenvalue 1 of Sh has multiplicity 1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.529300
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  • 4
    Electronic Resource
    Electronic Resource
    Optically generated liquid crystal gratings (1994)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 65 (1994), S. 2542-2544 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Optically controlled planar orientation of liquid crystal molecules with polarized light is used to make phase gratings in liquid crystal media. The electro-optical properties of liquid crystal linear and chirped gratings are discussed. © 1994 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.112629
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  • 5
    Electronic Resource
    Electronic Resource
    High-power Nd:glass laser transmission through optical fibers and its use in acceleration of thin foil targets (1990)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 67 (1990), S. 3297-3301 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Measurements on commercially available fused silica fibers and fiber tapers have shown that Nd:glass laser pulses of irradiance 〉3.5 GW cm−2 can be transmitted without bulk or surface damage. Optical energy at the fiber output can be used for efficient acceleration of thin metal foils. For 0.025-mm-thick aluminum coupled to a 0.2-mm-diam fiber, target foil velocities up to 2.3 km s−1 have been achieved with very modest laser energies (〈25 mJ).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.345364
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  • 6
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    Genetic Correction of p67phox Deficient Chronic Granulomatous Disease Using Peripheral Blood Progenitor Cells as a Target for Retrovirus Mediated Gene Transfer (1997)
    American Society of Hematology
    Details
    Publication Date: 1997-03-01
    Description: Chronic granulomatous disease (CGD) can result from any of four single gene defects involving the components of the superoxide (O−2 ) generating phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. We show that transduction of peripheral blood CD34+ hematopoietic progenitors from a p67phox deficient CGD patient with replication defective amphotropic retrovirus encoding p67phox (MFGS-p67phox) significantly corrected the CGD functional defect in phagocyte oxidase activity in vitro. Using a chemiluminescence assay of oxidase activity, we showed that transduced patient CD34+ progenitors differentiating to myeloid cells in culture produced 25% of the total superoxide produced by normal CD34+ progenitors differentiating in culture. A flow cytometric assay of oxidase activity used to assess the oxidase function of individual cells in the cultures indicated that up to 32% of maturing granulocytes derived from transduced CD34+ progenitors from the p67phox CGD patient were oxidase positive with the average level of correction per granulocyte of 85% of that seen with granulocytes in similar cultures of CD34+ progenitors from normal volunteers. Nitroblue tetrazolium dye reduction assays of colonies of transduced progenitors in soft agar indicated that in some studies restoration of oxidase activity occurred in myeloid cells within 44% of granulocyte-erythrocyte-monocyte colonies, and within 28% of the combined group of granulocyte colonies/monocyte colonies/granulocyte-monocyte colonies. These high correction rates were achieved without any selective regimen to enrich for transduced cells. This study provides a basis for development of gene therapy for the p67phox deficient form of CGD.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
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  • 7
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    Genetic Correction of p67phox Deficient Chronic Granulomatous Disease Using Peripheral Blood Progenitor Cells as a Target for Retrovirus Mediated Gene Transfer (1997)
    American Society of Hematology
    Details
    Publication Date: 1997-03-01
    Description: Chronic granulomatous disease (CGD) can result from any of four single gene defects involving the components of the superoxide (O−2 ) generating phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. We show that transduction of peripheral blood CD34+ hematopoietic progenitors from a p67phox deficient CGD patient with replication defective amphotropic retrovirus encoding p67phox (MFGS-p67phox) significantly corrected the CGD functional defect in phagocyte oxidase activity in vitro. Using a chemiluminescence assay of oxidase activity, we showed that transduced patient CD34+ progenitors differentiating to myeloid cells in culture produced 25% of the total superoxide produced by normal CD34+ progenitors differentiating in culture. A flow cytometric assay of oxidase activity used to assess the oxidase function of individual cells in the cultures indicated that up to 32% of maturing granulocytes derived from transduced CD34+ progenitors from the p67phox CGD patient were oxidase positive with the average level of correction per granulocyte of 85% of that seen with granulocytes in similar cultures of CD34+ progenitors from normal volunteers. Nitroblue tetrazolium dye reduction assays of colonies of transduced progenitors in soft agar indicated that in some studies restoration of oxidase activity occurred in myeloid cells within 44% of granulocyte-erythrocyte-monocyte colonies, and within 28% of the combined group of granulocyte colonies/monocyte colonies/granulocyte-monocyte colonies. These high correction rates were achieved without any selective regimen to enrich for transduced cells. This study provides a basis for development of gene therapy for the p67phox deficient form of CGD.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
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  • 8
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    Inositol tetrakisphosphate limits NK cell effector functions by controlling PI3K signaling (2013)
    American Society of Hematology
    Details
    Publication Date: 2013-01-10
    Description: Natural killer (NK) cells have important functions in cancer immunosurveillance, BM allograft rejection, fighting infections, tissue homeostasis, and reproduction. NK cell–based therapies are promising treatments for blood cancers. Overcoming their currently limited efficacy requires a better understanding of the molecular mechanisms controlling NK cell development and dampening their effector functions. NK cells recognize the loss of self-antigens or up-regulation of stress-induced ligands on pathogen-infected or tumor cells through invariant NK cell receptors (NKRs), and then kill such stressed cells. Two second-messenger pathways downstream of NKRs are required for NK cell maturation and effector responses: PIP3 generation by PI3K and generation of diacylglycerol and IP3 by phospholipase-Cγ (PLCγ). In the present study, we identify a novel role for the phosphorylated IP3 metabolite inositol (1,3,4,5)tetrakisphosphate (IP4) in NK cells. IP4 promotes NK cell terminal differentiation and acquisition of a mature NKR repertoire. However, in mature NK cells, IP4 limits NKR-induced IFNγ secretion, granule exocytosis, and target-cell killing, in part by inhibiting the PIP3 effector-kinase Akt. This identifies IP4 as an important novel regulator of NK cell development and function and expands our understanding of the therapeutically important mechanisms dampening NK cell responses. Our results further suggest that PI3K regulation by soluble IP4 is a broadly important signaling paradigm.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
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  • 9
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    Development of thymic NK cells from double negative 1 thymocyte precursors (2011)
    American Society of Hematology
    Details
    Publication Date: 2011-09-29
    Description: The differentiation of natural killer (NK) cells and a subpopulation of NK cells which requires an intact thymus, that is, thymic NK cells, is poorly understood. Previous in vitro studies indicate that double negative (CD4−CD8−, DN) thymocytes can develop into cells with NK cell markers, but these cells have not been well characterized. Herein, we generated and characterized NK cells differentiating from thymic DN precursors. Sorted DN1 (CD44+CD25−) CD122−NK1.1− thymocytes from Rag1−/− mice were adoptively transferred into Rag1−/−Ly5.1 congenic mice. After intrathymic injection, donor-derived cells phenotypically resembling thymic NK cells were found. To further study their differentiation, we seeded sorted DN1 CD122−NK1.1− thymocytes on irradiated OP9 bone marrow stromal cells with IL-15, IL-7, Flt3L, and stem cell factor. NK1.1+ cells emerged after 7 days. In vitro differentiated NK cells acquired markers associated with immature bone marrow–derived NK cells, but also expressed CD127, which is typically found on thymic NK cells. Furthermore, we found that in vitro cells generated from thymic precursors secreted cytokines when stimulated and degranulated on target exposure. Together, these data indicate that functional thymic NK cells can develop from a DN1 progenitor cell population.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
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  • 10
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    Cosmic-ray ionization in the lower atmosphere (1966)
    American Geophysical Union
    Details
    Publication Date: 1966-10-01
    Print ISSN: 0148-0227
    Electronic ISSN: 2156-2202
    Topics: Geosciences
    Published by American Geophysical Union
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