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  • Nucleic acid structure, Computational Methods  (2)
  • Chromatin and Epigenetics, Genomics  (1)
  • Civilization, Classical.  (1)
  • Geomagnetism, Rock Magnetism and Palaeomagnetism  (1)
  • Oxford University Press  (5)
  • Deutsches GeoForschungsZentrum GFZ
  • Institute of Physics
  • National Academy of Sciences
  • 2010-2014  (4)
  • 2000-2004  (1)
  • 1920-1924
Sammlung
Schlagwörter
Verlag/Herausgeber
  • Oxford University Press  (5)
  • Deutsches GeoForschungsZentrum GFZ
  • Institute of Physics
  • National Academy of Sciences
Erscheinungszeitraum
  • 2010-2014  (4)
  • 2000-2004  (1)
  • 1920-1924
Jahr
  • 1
    Unbekannt
    Studies in classical history and society (2002)
    Oxford [England] ; New York : Oxford University Press
    American classical studies  
    Details
    Schlagwort(e): Greece, History, To 146 B.C. ; Grèce, Histoire, Jusqu'à 146 av. J.-C. ; Rome, Histoire. ; Rome, History. ; Civilisation ancienne. ; Civilization, Classical.
    Seiten: xi, 151 p.
    ISBN: 0-19-518490-4
    URL: http://www.netLibrary.com/urlapi.asp?action=summary&v=1&bookid=121005
    Standort Signatur Erwartet Verfügbarkeit
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    E-Book (Nationallizenzen)
  • 2
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    SNP-guided identification of monoallelic DNA-methylation events from enrichment-based sequencing data (2014)
    Oxford University Press
    Details
    Publikationsdatum: 2014-11-12
    Beschreibung: Monoallelic gene expression is typically initiated early in the development of an organism. Dysregulation of monoallelic gene expression has already been linked to several non-Mendelian inherited genetic disorders. In humans, DNA-methylation is deemed to be an important regulator of monoallelic gene expression, but only few examples are known. One important reason is that current, cost-affordable truly genome-wide methods to assess DNA-methylation are based on sequencing post-enrichment. Here, we present a new methodology based on classical population genetic theory, i.e. the Hardy–Weinberg theorem, that combines methylomic data from MethylCap-seq with associated SNP profiles to identify monoallelically methylated loci. Applied on 334 MethylCap-seq samples of very diverse origin, this resulted in the identification of 80 genomic regions featured by monoallelic DNA-methylation. Of these 80 loci, 49 are located in genic regions of which 25 have already been linked to imprinting. Further analysis revealed statistically significant enrichment of these loci in promoter regions, further establishing the relevance and usefulness of the method. Additional validation was done using both 14 whole-genome bisulfite sequencing data sets and 16 mRNA-seq data sets. Importantly, the developed approach can be easily applied to other enrichment-based sequencing technologies, like the ChIP-seq-based identification of monoallelic histone modifications.
    Schlagwort(e): Chromatin and Epigenetics, Genomics
    Print ISSN: 0305-1048
    Digitale ISSN: 1362-4962
    Thema: Biologie
    Publiziert von Oxford University Press
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    R-CHIE: a web server and R package for visualizing RNA secondary structures (2012)
    Oxford University Press
    Details
    Publikationsdatum: 2012-06-28
    Beschreibung: Visually examining RNA structures can greatly aid in understanding their potential functional roles and in evaluating the performance of structure prediction algorithms. As many functional roles of RNA structures can already be studied given the secondary structure of the RNA, various methods have been devised for visualizing RNA secondary structures. Most of these methods depict a given RNA secondary structure as a planar graph consisting of base-paired stems interconnected by roundish loops. In this article, we present an alternative method of depicting RNA secondary structure as arc diagrams. This is well suited for structures that are difficult or impossible to represent as planar stem-loop diagrams. Arc diagrams can intuitively display pseudo-knotted structures, as well as transient and alternative structural features. In addition, they facilitate the comparison of known and predicted RNA secondary structures. An added benefit is that structure information can be displayed in conjunction with a corresponding multiple sequence alignments, thereby highlighting structure and primary sequence conservation and variation. We have implemented the visualization algorithm as a web server R- chie as well as a corresponding R package called R4RNA, which allows users to run the software locally and across a range of common operating systems.
    Schlagwort(e): Nucleic acid structure, Computational Methods
    Print ISSN: 0305-1048
    Digitale ISSN: 1362-4962
    Thema: Biologie
    Publiziert von Oxford University Press
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    Calibration of SQUID vector magnetometers in full tensor gradiometry systems (2014)
    Oxford University Press
    Details
    Publikationsdatum: 2014-06-28
    Beschreibung: Measurement of magnetic vector or tensor quantities, namely of field or field gradient, delivers more details of the underlying geological setting in geomagnetic prospection than a scalar measurement of a single component or of the scalar total magnetic intensity. Currently, highest measurement resolutions are achievable with superconducting quantum interference device (SQUID)-based systems. Due to technological limitations, it is necessary to suppress the parasitic magnetic field response from the SQUID gradiometer signals, which are a superposition of one tensor component and all three orthogonal magnetic field components. This in turn requires an accurate estimation of the local magnetic field. Such a measurement can itself be achieved via three additional orthogonal SQUID reference magnetometers. It is the calibration of such a SQUID reference vector magnetometer system that is the subject of this paper. A number of vector magnetometer calibration methods are described in the literature. We present two methods that we have implemented and compared, for their suitability of rapid data processing and integration into a full tensor magnetic gradiometry, SQUID-based, system. We conclude that the calibration routines must necessarily model fabrication misalignments, field offset and scale factors, and include comparison with a reference magnetic field. In order to enable fast processing on site, the software must be able to function as a stand-alone toolbox.
    Schlagwort(e): Geomagnetism, Rock Magnetism and Palaeomagnetism
    Print ISSN: 0956-540X
    Digitale ISSN: 1365-246X
    Thema: Geologie und Paläontologie
    Publiziert von Oxford University Press im Namen von The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
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    COFOLD: an RNA secondary structure prediction method that takes co-transcriptional folding into account (2013)
    Oxford University Press
    Details
    Publikationsdatum: 2013-05-04
    Beschreibung: Existing state-of-the-art methods that take a single RNA sequence and predict the corresponding RNA secondary structure are thermodynamic methods. These aim to predict the most stable RNA structure. There exists by now ample experimental and theoretical evidence that the process of structure formation matters and that sequences in vivo fold while they are being transcribed. None of the thermodynamic methods, however, consider the process of structure formation. Here, we present a conceptually new method for predicting RNA secondary structure, called C o F old , that takes effects of co-transcriptional folding explicitly into account. Our method significantly improves the state-of-art in terms of prediction accuracy, especially for long sequences of 〉1000 nt in length.
    Schlagwort(e): Nucleic acid structure, Computational Methods
    Print ISSN: 0305-1048
    Digitale ISSN: 1362-4962
    Thema: Biologie
    Publiziert von Oxford University Press
    Standort Signatur Erwartet Verfügbarkeit
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