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Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice (2013)

C. B. Peek ; A. H. Affinati ; K. M. Ramsey ; [weitere]

American Association for the Advancement of Science (AAAS)

In: Science. 342(6158): 1243417. doi: 10.1126/science.1243417.

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Publikationsdatum: 2013-09-21

Beschreibung: Circadian clocks are self-sustained cellular oscillators that synchronize oxidative and reductive cycles in anticipation of the solar cycle. We found that the clock transcription feedback loop produces cycles of nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, adenosine triphosphate production, and mitochondrial respiration through modulation of mitochondrial protein acetylation to synchronize oxidative metabolic pathways with the 24-hour fasting and feeding cycle. Circadian control of the activity of the NAD(+)-dependent deacetylase sirtuin 3 (SIRT3) generated rhythms in the acetylation and activity of oxidative enzymes and respiration in isolated mitochondria, and NAD(+) supplementation restored protein deacetylation and enhanced oxygen consumption in circadian mutant mice. Thus, circadian control of NAD(+) bioavailability modulates mitochondrial oxidative function and organismal metabolism across the daily cycles of fasting and feeding.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963134/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963134/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peek, Clara Bien -- Affinati, Alison H -- Ramsey, Kathryn Moynihan -- Kuo, Hsin-Yu -- Yu, Wei -- Sena, Laura A -- Ilkayeva, Olga -- Marcheva, Biliana -- Kobayashi, Yumiko -- Omura, Chiaki -- Levine, Daniel C -- Bacsik, David J -- Gius, David -- Newgard, Christopher B -- Goetzman, Eric -- Chandel, Navdeep S -- Denu, John M -- Mrksich, Milan -- Bass, Joseph -- 5P01HL071643-10/HL/NHLBI NIH HHS/ -- 5P30AR057216-05/AR/NIAMS NIH HHS/ -- F30 DK085936/DK/NIDDK NIH HHS/ -- F30 ES019815/ES/NIEHS NIH HHS/ -- F32 DK092034/DK/NIDDK NIH HHS/ -- P01 AG011412/AG/NIA NIH HHS/ -- P01AG011412-16/AG/NIA NIH HHS/ -- P01DK58398/DK/NIDDK NIH HHS/ -- P30 CA014520/CA/NCI NIH HHS/ -- R01 AG038679/AG/NIA NIH HHS/ -- R01 CA152601-01/CA/NCI NIH HHS/ -- R01 CA152799-01A1/CA/NCI NIH HHS/ -- R01 CA16383801A1/CA/NCI NIH HHS/ -- R01 CA168292/CA/NCI NIH HHS/ -- R01 CA168292-01A1/CA/NCI NIH HHS/ -- R01 DK090242/DK/NIDDK NIH HHS/ -- R01 DK090625/DK/NIDDK NIH HHS/ -- R01 GM065386/GM/NIGMS NIH HHS/ -- R01 HL097817/HL/NHLBI NIH HHS/ -- R01DK090242-03/DK/NIDDK NIH HHS/ -- R01DK090625-01A1/DK/NIDDK NIH HHS/ -- R01HL097817-01/HL/NHLBI NIH HHS/ -- R37 GM059785/GM/NIGMS NIH HHS/ -- T32 DK007169/DK/NIDDK NIH HHS/ -- T32 GM008152/GM/NIGMS NIH HHS/ -- T32 HL007909/HL/NHLBI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Nov 1;342(6158):1243417. doi: 10.1126/science.1243417. Epub 2013 Sep 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24051248" target="_blank"〉PubMed〈/a〉

Schlagwort(e): ARNTL Transcription Factors/genetics/metabolism ; Acetylation ; Animals ; Circadian Clocks/genetics/*physiology ; *Energy Metabolism ; Fasting ; Lipid Metabolism ; Liver/metabolism ; Mice ; Mice, Knockout ; Mitochondria, Liver/*metabolism ; NAD/*metabolism ; Oxidation-Reduction ; Oxygen Consumption ; Sirtuin 3/genetics/metabolism

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

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Circadian integration of metabolism and energetics (2010)

J. Bass ; J. S. Takahashi

American Association for the Advancement of Science (AAAS)

In: Science. 330(6009): 1349-54. doi: 10.1126/science.1195027.

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Publikationsdatum: 2010-12-04

Beschreibung: Circadian clocks align behavioral and biochemical processes with the day/night cycle. Nearly all vertebrate cells possess self-sustained clocks that couple endogenous rhythms with changes in cellular environment. Genetic disruption of clock genes in mice perturbs metabolic functions of specific tissues at distinct phases of the sleep/wake cycle. Circadian desynchrony, a characteristic of shift work and sleep disruption in humans, also leads to metabolic pathologies. Here, we review advances in understanding the interrelationship among circadian disruption, sleep deprivation, obesity, and diabetes and implications for rational therapeutics for these conditions.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756146/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756146/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bass, Joseph -- Takahashi, Joseph S -- P01 AG011412/AG/NIA NIH HHS/ -- P50 MH074924/MH/NIMH NIH HHS/ -- R01 HL097817/HL/NHLBI NIH HHS/ -- R01 MH078024/MH/NIMH NIH HHS/ -- R01HL097817/HL/NHLBI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2010 Dec 3;330(6009):1349-54. doi: 10.1126/science.1195027.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA. j-bass@northwestern.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21127246" target="_blank"〉PubMed〈/a〉

Schlagwort(e): Animals ; *Circadian Clocks/genetics/physiology ; Diabetes Mellitus/metabolism/physiopathology ; *Energy Metabolism ; Feedback, Physiological ; Gene Expression Regulation ; Gene Regulatory Networks ; Homeostasis ; Humans ; Metabolic Networks and Pathways ; *Metabolism ; Obesity/metabolism/physiopathology ; Protein Biosynthesis ; Signal Transduction ; Sleep Deprivation/metabolism/physiopathology ; Sleep Disorders, Circadian Rhythm/metabolism ; Transcription, Genetic

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

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Open data: crediting a culture of cooperation (2013)

B. Bolukbasi ; N. Berente ; J. Cutcher-Gershenfeld ; [weitere]

American Association for the Advancement of Science (AAAS)

In: Science. 342(6162): 1041-2. doi: 10.1126/science.342.6162.1041-b.

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Publikationsdatum: 2013-11-30

Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bolukbasi, Burcu -- Berente, Nicholas -- Cutcher-Gershenfeld, Joel -- Dechurch, Leslie -- Flint, Courtney -- Haberman, Michael -- King, John Leslie -- Knight, Eric -- Lawrence, Barbara -- Masella, Ethan -- McElroy, Charles -- Mittleman, Barbara -- Nolan, Mark -- Radik, Melanie -- Shin, Namchul -- Thompson, Cheryl A -- Winter, Susan -- Zaslavsky, Ilya -- Allison, M Lee -- Arctur, David -- Arrigo, Jennifer -- Aufdenkampe, Anthony K -- Bass, Jay -- Crowell, Jim -- Daniels, Mike -- Diggs, Stephen -- Duffy, Christopher -- Gil, Yolanda -- Gomez, Basil -- Graves, Sara -- Hazen, Robert -- Hsu, Leslie -- Kinkade, Danie -- Lehnert, Kerstin -- Marone, Chris -- Middleton, Don -- Noren, Anders -- Pearthree, Genevieve -- Ramamurthy, Mohan -- Robinson, Erin -- Percivall, George -- Richard, Stephen -- Suarez, Celina -- Walker, Doug -- New York, N.Y. -- Science. 2013 Nov 29;342(6162):1041-2. doi: 10.1126/science.342.6162.1041-b.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Labor and Employment Relations, University of Illinois at Urbana-Champaign, Champaign, IL 61820, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24288316" target="_blank"〉PubMed〈/a〉

Schlagwort(e): *Access to Information ; Periodicals as Topic/*economics ; Research/*economics

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

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The Melting Curve of Iron to 250 Gigapascals: A Constraint on the Temperature at Earth's Center (1987)

Q. Williams ; R. Jeanloz ; J. Bass ; [weitere]

American Association for the Advancement of Science (AAAS)

In: Science. 236(4798): 181-2. doi: 10.1126/science.236.4798.181.

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Publikationsdatum: 1987-04-10

Beschreibung: The melting curve of iron, the primary constituent of Earth's core, has been measured to pressures of 250 gigapascals with a combination of static and dynamic techniques. The melting temperature of iron at the pressure of the core-mantle boundary (136 gigapascals) is 4800 +/- 200 K. whereas at the inner core-outer core boundary (330 gigapascals), it is 7600 +/- 500 K. Corrected for melting point depression resulting from the presence of impurities, a melting temperature for iron-rich alloy of 6600 K at the inner core-outer core boundary and a maximum temperature of 6900 K at Earth's center are inferred. This latter value is the first experimental upper bound on the temperature at Earth's center, and these results imply that the temperature of the lower mantle is significantly less than that of the outer core.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williams, Q -- Jeanloz, R -- Bass, J -- Svendsen, B -- Ahrens, T J -- New York, N.Y. -- Science. 1987 Apr 10;236(4798):181-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17789782" target="_blank"〉PubMed〈/a〉

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

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Digitale Medien

Studies on Chironomidae in experimental recirculating stream systems. II. The growth, development and production of a spring generation of Orthocladius (Euorthodadius) calvus Pinder (1985)

LADLE, M. ; COOLING, D. A. ; WELTON, J. S. ; [weitere]

Oxford, UK : Blackwell Publishing Ltd

Freshwater biology 15 (1985), S. 0

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ISSN: 1365-2427

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Biologie

Notizen: SUMMARY. 〈list xml:id="l1" style="custom"〉1 Orthodadius (Euorthodadius) calvus Pinder. similar to Orthocladius (Euorthodadius) thienemanni Kieffer. colonized a new gravel substratum in two recirculating stream channels. A maximum population density of 68.621 m-2 was attained after only 16 days. This had fallen to a negligible density by the thirty-third day.2Some recruitment occurred over most of the study period (April-May 1981) and no single sharply defined cohort was evident. There was a large range of body lengths within each instar. and considerable overlap between instars. The population density estimates for instars I and II were low compared with instars III and IV.3The relationship between instantaneous growth rate (g) and geometric mean length indicated that growth was best described by a Gompertz curve. Growth rate decreased with increasing length from a value of about 40% length day-1 at 2 mm body length to about 5% length day-1 at 9 mm.4Growth rates for individual larvae, kept in culture, were very variable with maximum rates close to the values determined from the field data. Mean duration of larval life was 16 days.5Estimates of production for the study period ranged from 13.5 g dry wt m-2 (Channel III, size-frequency method) to 34.2 g dry wt m-2 (Channel II, Allen's graphical method, values corrected for non-linear growth).6Gut contents were estimated to represent about 55% of the total weight therefore production values should be reduced by this amount.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1365-2427.1985.tb00197.x

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Evidence of denser MgSiO3 glass above 133 gigapascal (GPa) and implications for remnants of ultradense silicate melt from a deep magma ocean (2011)

Murakami, M. ; Bass, J. D.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(42): 17286-17289. Published 2011 Oct 03. doi: 10.1073/pnas.1109748108.

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Publikationsdatum: 2011-10-03

Print ISSN: 0027-8424

Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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Furin-mediated processing in the early secretory pathway: Sequential cleavage and degradation of misfolded insulin receptors (2000)

Bass, J. ; Turck, C. ; Rouard, M. ; [weitere]

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences of the United States of America. 2000; 97(22): 11905-11909. Published 2000 Oct 24. doi: 10.1073/pnas.97.22.11905.

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Publikationsdatum: 2000-10-24

Print ISSN: 0027-8424

Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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Evidence of denser MgSiO3 glass above 133 gigapascal (GPa) and implications for remnants of ultradense silicate melt from a deep magma ocean [Geophysics] (2011)

Murakami, M., Bass, J. D.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publikationsdatum: 2011-10-19

Beschreibung: Ultralow velocity zones are the largest seismic anomalies in the mantle, with 10–30% seismic velocity reduction observed in thin layers less than 20–40 km thick, just above the Earth’s core-mantle boundary (CMB). The presence of silicate melts, possibly a remnant of a deep magma ocean in the early Earth, have been proposed to explain ultralow velocity zones. It is, however, still an open question as to whether such silicate melts are gravitationally stable at the pressure conditions above the CMB. Fe enrichment is usually invoked to explain why melts would remain at the CMB, but this has not been substantiated experimentally. Here we report in situ high-pressure acoustic velocity measurements that suggest a new transformation to a denser structure of MgSiO3 glass at pressures close to those of the CMB. The result suggests that MgSiO3 melt is likely to become denser than crystalline MgSiO3 above the CMB. The presence of negatively buoyant and gravitationally stable silicate melts at the bottom of the mantle, would provide a mechanism for observed ultralow seismic velocities above the CMB without enrichment of Fe in the melt. An ultradense melt phase and its geochemical inventory would be isolated from overlying convective flow over geologic time.

Print ISSN: 0027-8424

Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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