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  • Animals  (4)
  • Aircraft Design, Testing and Performance  (2)
  • 2010-2014  (3)
  • 2005-2009  (2)
  • 1965-1969  (1)
  • 1
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    Biochemistry. Nature's intricate clockwork (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2012-07-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crane, Brian R -- New York, N.Y. -- Science. 2012 Jul 13;337(6091):165-6. doi: 10.1126/science.1224611.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14850, USA. bc69@cornell.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22798591" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): ARNTL Transcription Factors/*chemistry ; Animals ; CLOCK Proteins/*chemistry ; *Circadian Rhythm ; Humans ; *Transcriptional Activation
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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    AKTUELLE ARTIKEL
  • 2
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    Ecology: The Convention on Biological Diversity's 2010 target (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2005-01-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balmford, Andrew -- Bennun, Leon -- Brink, Ben Ten -- Cooper, David -- Cote, Isabelle M -- Crane, Peter -- Dobson, Andrew -- Dudley, Nigel -- Dutton, Ian -- Green, Rhys E -- Gregory, Richard D -- Harrison, Jeremy -- Kennedy, Elizabeth T -- Kremen, Claire -- Leader-Williams, Nigel -- Lovejoy, Thomas E -- Mace, Georgina -- May, Robert -- Mayaux, Phillipe -- Morling, Paul -- Phillips, Joanna -- Redford, Kent -- Ricketts, Taylor H -- Rodriguez, Jon Paul -- Sanjayan, M -- Schei, Peter J -- van Jaarsveld, Albert S -- Walther, Bruno A -- New York, N.Y. -- Science. 2005 Jan 14;307(5707):212-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cambridge University and University of Cape Town.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15653489" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Biodiversity ; *Conservation of Natural Resources ; *Ecology ; Ecosystem ; Humans ; Interdisciplinary Communication ; International Cooperation ; Models, Biological ; Models, Theoretical ; Public Policy
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    Structure of full-length Drosophila cryptochrome (2011)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2011-11-15
    Beschreibung: The cryptochrome/photolyase (CRY/PL) family of photoreceptors mediates adaptive responses to ultraviolet and blue light exposure in all kingdoms of life. Whereas PLs function predominantly in DNA repair of cyclobutane pyrimidine dimers (CPDs) and 6-4 photolesions caused by ultraviolet radiation, CRYs transduce signals important for growth, development, magnetosensitivity and circadian clocks. Despite these diverse functions, PLs/CRYs preserve a common structural fold, a dependence on flavin adenine dinucleotide (FAD) and an internal photoactivation mechanism. However, members of the CRY/PL family differ in the substrates recognized (protein or DNA), photochemical reactions catalysed and involvement of an antenna cofactor. It is largely unknown how the animal CRYs that regulate circadian rhythms act on their substrates. CRYs contain a variable carboxy-terminal tail that appends the conserved PL homology domain (PHD) and is important for function. Here, we report a 2.3-A resolution crystal structure of Drosophila CRY with an intact C terminus. The C-terminal helix docks in the analogous groove that binds DNA substrates in PLs. Conserved Trp 536 juts into the CRY catalytic centre to mimic PL recognition of DNA photolesions. The FAD anionic semiquinone found in the crystals assumes a conformation to facilitate restructuring of the tail helix. These results help reconcile the diverse functions of the CRY/PL family by demonstrating how conserved protein architecture and photochemistry can be elaborated into a range of light-driven functions.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240699/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240699/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zoltowski, Brian D -- Vaidya, Anand T -- Top, Deniz -- Widom, Joanne -- Young, Michael W -- Crane, Brian R -- GM054339/GM/NIGMS NIH HHS/ -- GM079679/GM/NIGMS NIH HHS/ -- R01 GM079679/GM/NIGMS NIH HHS/ -- R01 GM079679-06/GM/NIGMS NIH HHS/ -- R37 GM054339/GM/NIGMS NIH HHS/ -- R37 GM054339-16/GM/NIGMS NIH HHS/ -- England -- Nature. 2011 Nov 13;480(7377):396-9. doi: 10.1038/nature10618.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22080955" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Motifs ; Animals ; Arthropod Antennae ; Catalytic Domain ; Cryptochromes/*chemistry/metabolism ; Crystallography, X-Ray ; DNA/chemistry/metabolism ; Drosophila melanogaster/*chemistry ; Flavin-Adenine Dinucleotide/metabolism ; Models, Molecular ; Oxidation-Reduction ; Protein Conformation ; Substrate Specificity ; Tryptophan/chemistry/metabolism
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von Nature Publishing Group (NPG)
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    Updated structure of Drosophila cryptochrome (2013)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2013-03-23
    Beschreibung: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694752/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694752/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levy, Colin -- Zoltowski, Brian D -- Jones, Alex R -- Vaidya, Anand T -- Top, Deniz -- Widom, Joanne -- Young, Michael W -- Scrutton, Nigel S -- Crane, Brian R -- Leys, David -- R01 GM079679/GM/NIGMS NIH HHS/ -- R37 GM054339/GM/NIGMS NIH HHS/ -- England -- Nature. 2013 Mar 21;495(7441):E3-4. doi: 10.1038/nature11995.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23518567" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cryptochromes/chemistry ; Drosophila/*chemistry ; *Models, Molecular ; Protein Structure, Tertiary
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von Nature Publishing Group (NPG)
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
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    Low-Speed Flight Characteristics of a Powered-Lift Jet Transport During the Landing Approach (1965)
    In:  CASI
    Details
    Publikationsdatum: 2004-12-03
    Beschreibung: A flight-test program to determine the flight characteristics of large jet transports equipped with powered-lift systems indicated the following results: Speed margins appear to be primarily related to power-on stall speeds. At these speed margins, the maneuver margins were adequate and did not appear to be a problem or limiting factor during powered-lift operation. No large detrimental effects on handling qualities were apparent but in some areas stability augmentation would be required to obtain satisfactory flight characteristics. Use of the powered-lift airplane would result in a sizable increase in the noise levels; these increases are primarily the result of higher engine power settings in the approach.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA Conference on Aircraft Operating Problems: A Compilation of the Papers Presented; 319-327
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
  • 6
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    Development and Assessment of a Novel Training Package for Basic Maneuvering Tasks on a Flight Simulator Using Self Instruction Methods and Above Real Time Training (ARTT) (2007)
    In:  CASI
    Details
    Publikationsdatum: 2019-07-13
    Beschreibung: One result of the relatively recent advances in computing technology has been the decreasing cost of computers and increasing computational power. This has allowed high fidelity airplane simulations to be run on personal computers (PC). Thus, simulators are now used routinely by pilots to substitute real flight hours for simulated flight hours for training for an aircraft type rating thereby reducing the cost of flight training. However, FAA regulations require that such substitution training must be supervised by Certified Flight Instructors (CFI). If the CFI presence could be reduced or eliminated for certain tasks this would mean a further cost savings to the pilot. This would require that the flight simulator have a certain level of 'intelligence' in order to provide feedback on pilot performance similar to that of a CFI. The 'intelligent' flight simulator would have at least the capability to use data gathered from the flight to create a measure for the performance of the student pilot. Also, to fully utilize the advances in computational power, the simulator would be capable of interacting with the student pilot using the best possible training interventions. This thesis reports on the two studies conducted at Tuskegee University investigating the effects of interventions on the learning of two flight maneuvers on a flight simulator and the robustness and accuracy of calculated performance indices as compared to CFI evaluations of performance. The intent of these studies is to take a step in the direction of creating an 'intelligent' flight simulator. The first study deals with the comparisons of novice pilot performance trained at different levels of above real-time to execute a level S-turn. The second study examined the effect of out-of-the-window (OTW) visual cues in the form of hoops on the performance of novice pilots learning to fly a landing approach on the flight simulator. The reliability/robustness of the computed performance metrics was assessed by comparing them with the evaluations of the landing approach maneuver by a number of CFIs.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: DUNNS-128214178
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
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