Publication Date:
2013-06-19
Description:
Article Mutations in the E3 ubiquitin ligase parkin are associated with juvenile Parkinson’s disease. Here the authors report the solution structure of the Parkin RING2 domain, revealing how disease-associated mutations affect its function and providing a molecular explanation for the recessive nature of the disease. Nature Communications doi: 10.1038/ncomms2983 Authors: Donald E. Spratt, R Julio Martinez-Torres, Yeong J. Noh, Pascal Mercier, Noah Manczyk, Kathryn R. Barber, Jacob D. Aguirre, Lynn Burchell, Andrew Purkiss, Helen Walden, Gary S. Shaw
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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