Publication Date:
2015-03-29
Description:
Article In response to microbial ligands, IRF5 promotes pro-inflammatory M1 macrophage activation and production of nitrous oxide. Here the authors show that nitrous oxide modifies IRF5 tyrosine residues as a negative feedback, limiting the inflammatory response and protecting from endotoxin shock. Nature Communications doi: 10.1038/ncomms7676 Authors: Geming Lu, Ruihua Zhang, Shuo Geng, Liang Peng, Padmini Jayaraman, Chun Chen, Feifong Xu, Jianjun Yang, Qin Li, Hao Zheng, Kimberly Shen, Juan Wang, Xiyu Liu, Weidong Wang, Zihan Zheng, Chen-Feng Qi, Chuanping Si, John Cijiang He, Kebin Liu, Sergio A. Lira, Andrew G. Sikora, Liwu Li, Huabao Xiong
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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