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  • 1
    Publication Date: 2015-05-30
    Description: Influenza A virus (IAV) has a segmented genome that allows for the exchange of genome segments between different strains. This reassortment accelerates evolution by breaking linkage, helping IAV cross species barriers to potentially create highly virulent strains. Challenges associated with monitoring the process of reassortment in molecular detail have limited our understanding of its evolutionary implications. We applied a novel deep sequencing approach with quantitative analysis to assess the in vitro temporal evolution of genomic reassortment in IAV. The combination of H1N1 and H3N2 strains reproducibly generated a new H1N2 strain with the hemagglutinin and nucleoprotein segments originating from H1N1 and the remaining six segments from H3N2. By deep sequencing the entire viral genome, we monitored the evolution of reassortment, quantifying the relative abundance of all IAV genome segments from the two parent strains over time and measuring the selection coefficients of the reassorting segments. Additionally, we observed several mutations coemerging with reassortment that were not found during passaging of pure parental IAV strains. Our results demonstrate how reassortment of the segmented genome can accelerate viral evolution in IAV, potentially enabled by the emergence of a small number of individual mutations.
    Print ISSN: 0737-4038
    Electronic ISSN: 1537-1719
    Topics: Biology
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  • 2
    Publication Date: 2015-10-16
    Description: The large-scale geological evolution of the North Atlantic Realm during the past 450 Myr is largely understood, but crucial elements remain uncertain. These involve the Caledonian orogeny, the formation of the North Atlantic and accompanying igneous activity, and the present-day high topography surrounding the North Atlantic. Teleseismic receiver function interpretation in the Central Fjord Region of East Greenland recently suggested the presence of a fossil Caledonian subduction complex, including a slab of eclogitised mafic crust and an overlying wedge of serpentinised mantle peridotite. Here we further investigate this topic using inverse receiver functions modelling. The obtained velocity models are tested with regard to their consistency with the regional gravity field and topography. We find that the obtained receiver function model is generally consistent with gravity and isostasy. The western part of the section, with topography of 〉1000 m, is clearly supported by the 40-km-thick crust. The eastern part requires additional buoyancy as provided by the hydrated mantle wedge. The geometry, velocities and densities are consistent with interpretation of the lithospheric structure as a fossil subduction zone complex. The spatial relations with Caledonian structures suggest a Caledonian origin. The results indicate that topography is isostatically compensated by density variations within the lithosphere, and that significant dynamic topography is not required at the present-day.
    Keywords: Geodynamics and Tectonics
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 3
    Publication Date: 2015-07-01
    Description: Mutations in profilin 1 (PFN1) are associated with amyotrophic lateral sclerosis (ALS); however, the pathological mechanism of PFN1 in this fatal disease is unknown. We demonstrate that ALS-linked mutations severely destabilize the native conformation of PFN1 in vitro and cause accelerated turnover of the PFN1 protein in cells. This mutation-induced...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 4
    Publication Date: 2016-01-30
    Description: Ellesmere Island in Arctic Canada displays a complex geological evolution. The region was affected by two distinct orogenies, the Palaeozoic Ellesmerian orogeny (the Caledonian equivalent in Arctic Canada and Northern Greenland) and the Palaeogene Eurekan orogeny, related to the opening of Baffin Bay and the consequent convergence of the Greenland plate. The details of this complex evolution and the present-day deep structure are poorly constrained in this remote area and deep geophysical data are sparse. Receiver function analysis of seven temporary broad-band seismometers of the Ellesmere Island Lithosphere Experiment complemented by two permanent stations provides important data on the crustal velocity structure of Ellesmere Island. The crustal expression of the northernmost tectonic block of Ellesmere Island (~82°–83°N), Pearya, which was accreted during the Ellesmerian orogeny, is similar to that at the southernmost part, which is part of the Precambrian Laurentian (North America-Greenland) craton. Both segments have thick crystalline crust (~35–36 km) and comparable velocity–depth profiles. In contrast, crustal thickness in central Ellesmere Island decreases from ~24–30 km in the Eurekan fold and thrust belt (~79.7°–80.6°N) to ~16–20 km in the Hazen Stable Block (HSB; ~80.6°–81.4°N) and is covered by a thick succession of metasediments. A deep crustal root (~48 km) at ~79.6°N is interpreted as cratonic crust flexed beneath the Eurekan fold and thrust belt. The Carboniferous to Palaeogene sedimentary succession of the Sverdrup Basin is inferred to be up to 1–4 km thick, comparable to geologically-based estimates, near the western margin of the HSB.
    Keywords: Geodynamics and Tectonics
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 5
    Publication Date: 2019
    Description: 〈span〉〈div〉Summary〈/div〉The North Anatolian Fault Zone (NAFZ) is a major plate boundary that separates the Eurasian plate to the north from the Anatolian plate to the south and is associated with powerful damaging earthquakes. Despite numerous studies of the crust and upper mantle across the NAFZ, our understanding of the exact mechanisms and distribution of deformation with depth is still limited. Accurate models of the crustal velocity structure are key to assess seismic hazard associated with strike-slip deformation. Here, we address this need by employing a novel method that jointly inverts receiver function waveforms and P-wave polarisations to recover S-wave velocity structure from the surface to the upper mantle. The method is applied to a dense teleseismic dataset collected across a segment of the central NAFZ in Turkey. The results provide important new constraints on the sedimentary thickness, depth to basement and Moho discontinuity beneath the region. Our estimates of uppermost sedimentary thickness range from 0 km in some areas (e.g. beneath the Central Pontides) to 6 km in the Çankırı Basin. Smaller basins are scattered along the NAFZ. A similar pattern is observed for the basement depth, with values exceeding 10 km beneath the Çankırı Basin, where the Moho is shallowest with a depth of ∼32 km. The Moho reaches a maximum depth of ∼42 km beneath the Central Pontides. Most other areas have an average Moho depth of 35–38 km. The results reveal clear structural-tectonic relationships in the crust: areas of fundamentally different sedimentary and crustal architecture are bounded by faults and suture zones. The NAFZ appears to accommodate small-scale basin and basement-highs, and acts as a thick-skinned (i.e. full crustal-scale) boundary between laterally displaced crustal blocks to the north and south. Seismicity clusters are centred on areas of low Vp/Vs ratios that may be representative of weak zones.〈/span〉
    Print ISSN: 2051-1965
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 6
    Publication Date: 2018
    Description: 〈p〉The opening of the North Atlantic region was one of the most important geodynamic events that shaped the present day passive margins of Europe, Greenland and North America. Although well-studied, much remains to be understood about the evolution of the North Atlantic, including the role of the Jan Mayen microplate complex. Geophysical data provide an image of the crustal structure of this microplate and enable a detailed reconstruction of the rifting and spreading history. However, the mechanisms that cause the separation of microplates between conjugate margins are still poorly understood. We assemble recent models of rifting and passive margin formation in the North Atlantic and discuss possible scenarios that may have led to the formation of the Jan Mayen microplate complex. This event was probably triggered by regional plate tectonic reorganizations rejuvenating inherited structures. The axis of rifting and continental break-up and the width of the Jan Mayen microplate complex were controlled by old Caledonian fossil subduction/suture zones. Its length is related to east–west-oriented deformation and fracture zones, possibly linked to rheological heterogeneities inherited from the pre-existing Precambrian terrane boundaries.〈/p〉
    Print ISSN: 0375-6440
    Electronic ISSN: 2041-4927
    Topics: Geosciences
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  • 7
    Publication Date: 2018
    Description: 〈p〉This Editorial discusses the state of research on drug resistance in the fields of cancer, infectious disease, and agriculture. Reaching across the aisle for a more cross-collaborative approach may lead to exciting breakthroughs toward tackling the challenges of drug resistance in each field.〈/p〉
    Print ISSN: 1945-0877
    Electronic ISSN: 1937-9145
    Topics: Biology , Medicine
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  • 8
    Publication Date: 2017-09-30
    Description: New deep seismological data from Ellesmere Island and the adjacent Arctic continental margin provide new information about the crustal structure of the region. These data were not available for previous regional crustal models. This paper combines and redisplays previously published results – a gravity-derived Moho map and seismological results –to produce new maps of the Moho depth, the depth to basement and the crystalline crustal thickness of Ellesmere Island and contiguous parts of the Arctic Ocean, Greenland and Axel Heiberg Island. Northern Ellesmere Island is underlain by a thick crustal block (Moho at 41 km, c. 35 km crust). This block is separated from the Canada–Greenland craton in the south by a WSW–ENE-trending channel of thinned crystalline crust (Moho at 30–35 km, 〈20 km thick crust), which is overlain by a thick succession of metasedimentary and younger sedimentary rocks (15–20 km). The Sverdrup Basin in the west and the Lincoln Sea in the east interrupt the crustal architecture of central Ellesmere Island, which is interpreted to be more representative of its initial post-Ellesmerian Orogen structure, but with a later Sverdrup Basin and Eurekan overprint.
    Print ISSN: 0305-8719
    Electronic ISSN: 2041-4927
    Topics: Geosciences
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  • 9
    Publication Date: 2017-04-15
    Description: We use new models of crustal structure and the depth of the lithosphere–asthenosphere boundary to calculate the geopotential energy and its corresponding geopotential stress field for the High Arctic. Palaeostress indicators such as dykes and rifts of known age are used to compare the present day and palaeostress fields. When both stress fields coincide, a minimum age for the configuration of the lithospheric stress field may be defined. We identify three regions in which this is observed. In north Greenland and the eastern Amerasia Basin, the stress field is probably the same as that present during the Late Cretaceous. In western Siberia, the stress field is similar to that in the Triassic. The stress directions on the eastern Russian Arctic Shelf and the Amerasia Basin are similar to that in the Cretaceous. The persistent misfit of the present stress field and Early Cretaceous dyke swarms associated with the High Arctic Large Igneous Province indicates a short-lived transient change in the stress field at the time of dyke emplacement. Most Early Cretaceous rifts in the Amerasia Basin coincide with the stress field, suggesting that dyking and rifting were unrelated. We present new evidence for dykes and a graben structure of Early Cretaceous age on Bennett Island.
    Print ISSN: 0305-8719
    Electronic ISSN: 2041-4927
    Topics: Geosciences
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  • 10
    Publication Date: 2018-02-03
    Description: The opening of the North Atlantic region was one of the most important geodynamic events that shaped the present day passive margins of Europe, Greenland and North America. Although well-studied, much remains to be understood about the evolution of the North Atlantic, including the role of the Jan Mayen microplate complex. Geophysical data provide an image of the crustal structure of this microplate and enable a detailed reconstruction of the rifting and spreading history. However, the mechanisms that cause the separation of microplates between conjugate margins are still poorly understood. We assemble recent models of rifting and passive margin formation in the North Atlantic and discuss possible scenarios that may have led to the formation of the Jan Mayen microplate complex. This event was probably triggered by regional plate tectonic reorganizations rejuvenating inherited structures. The axis of rifting and continental break-up and the width of the Jan Mayen microplate complex were controlled by old Caledonian fossil subduction/suture zones. Its length is related to east–west-oriented deformation and fracture zones, possibly linked to rheological heterogeneities inherited from the pre-existing Precambrian terrane boundaries.
    Print ISSN: 0305-8719
    Electronic ISSN: 2041-4927
    Topics: Geosciences
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