Publication Date:
2016-02-14
Description:
Article Cellular senescence—the permanent cessation of cell proliferation—is a process that can be deregulated in cancer and other aging-related diseases. Here the authors demonstrate that the SCF Fbxo22 -KDM4A complex plays an essential role during senescence as an E3 ligase that targets methylated p53 for degradation. Nature Communications doi: 10.1038/ncomms10574 Authors: Yoshikazu Johmura, Jia Sun, Kyoko Kitagawa, Keiko Nakanishi, Toshiya Kuno, Aya Naiki-Ito, Yumi Sawada, Tomomi Miyamoto, Atsushi Okabe, Hiroyuki Aburatani, ShengFan Li, Ichiro Miyoshi, Satoru Takahashi, Masatoshi Kitagawa, Makoto Nakanishi
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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