ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Publication Date: 2017-09-22
    Description: Gene expression in metazoans is regulated by RNA polymerase II (Pol II) promoter-proximal pausing and its release. Previously, we showed that Pol II–associated factor 1 (PAF1) modulates the release of paused Pol II into productive elongation. Here, we found that PAF1 occupies transcriptional enhancers and restrains hyperactivation of a subset of these enhancers. Enhancer activation as the result of PAF1 loss releases Pol II from paused promoters of nearby PAF1 target genes. Knockout of PAF1-regulated enhancers attenuates the release of paused Pol II on PAF1 target genes without major interference in the establishment of pausing at their cognate promoters. Thus, a subset of enhancers can primarily modulate gene expression by controlling the release of paused Pol II in a PAF1-dependent manner.
    Keywords: Biochemistry, Development
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    Publication Date: 2019
    Description: 〈span〉〈div〉ABSTRACT〈/div〉Calcite cementation has been identified as an active process in the Upper Triassic Yanchang Formation throughout its burial history and as a major diagenetic factor causing strong reservoir heterogeneities. The origins of calcite cements and their relevance to reservoir heterogeneities were investigated using a suite of petrographic and geochemical methods, including optical microscopy with fluorescence and cathodoluminescence, scanning and backscattered electron microscopy with energy-dispersive spectrometry, x-ray diffraction, x-ray fluorescence, electron probe microanalysis, quantitative evaluation of minerals by scanning electron microscopy, fluid inclusion analysis, and carbon and oxygen stable isotope analyses. The sandstones are compositionally immature with relatively high amounts of volcanic rock fragments. The two generations of calcite cements are Ca-I and Ca-II. The Ca-I calcites are distributed along the interface of sandstone and mudstone units and were formed during the Late Triassic to Early Jurassic at formation temperatures of approximately 90°C. The Ca-II calcite mainly developed in the lower part of the fining-upward sandstone units and was formed in the Late Jurassic at higher temperatures of approximately 110°C. The origins of calcite cements were constrained by geochemical and isotope measurements, fluid inclusion homogenization temperature, and in situ element analysis. The Ca-I calcite cement originated from dissolution of the lacustrine depositional carbonates in the interbedded mudstones and reprecipitation in the adjacent sandstones. The Ca-II calcite was mainly related to organic matter decarboxylation, with Ca〈sup〉2+〈/sup〉 having been provided internally by volcanic fragment alteration and plagioclase dissolution. Calcite cementation had caused strong reservoir heterogeneities in the Yanchang Formation tight sandstones. The Ca-I calcite cementation destroyed reservoir properties along the interface of sandstones and mudstones. The lower parts of the fining-upward sandstone units were tightly cemented by Ca-II calcite, although they originally had high porosity and permeability. The middle–upper parts of the fining-upward sandstone units contain less calcite cements and thus have better preserved reservoir pores because of oil emplacement inhibiting the calcite cementation processes.〈/span〉
    Print ISSN: 0149-1423
    Electronic ISSN: 1943-2674
    Topics: Geosciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 3
    Publication Date: 2018-10-05
    Description: During 2017, the Cassini fluxgate magnetometer made in situ measurements of Saturn’s magnetic field at distances ~2550 ± 1290 kilometers above the 1-bar surface during 22 highly inclined Grand Finale orbits. These observations refine the extreme axisymmetry of Saturn’s internal magnetic field and show displacement of the magnetic equator northward from the planet’s physical equator. Persistent small-scale magnetic structures, corresponding to high-degree (〉3) axisymmetric magnetic moments, were observed. This suggests secondary shallow dynamo action in the semiconducting region of Saturn’s interior. Some high-degree magnetic moments could arise from strong high-latitude concentrations of magnetic flux within the planet’s deep dynamo. A strong field-aligned current (FAC) system is located between Saturn and the inner edge of its D-ring, with strength comparable to the high-latitude auroral FACs.
    Keywords: Geochemistry, Geophysics, Online Only, Planetary Science
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 4
    Publication Date: 2016-03-23
    Description: In contrast to other III-nitride semiconductors GaN and AlN, the intrinsic (or free) exciton transition in hexagonal boron nitride ( h- BN) consists of rather complex fine spectral features (resolved into six sharp emission peaks) and the origin of which is still unclear. Here, the free exciton transition (FX) in h- BN bulk crystals synthesized by a solution method at atmospheric pressure has been probed by deep UV time-resolved photoluminescence (PL) spectroscopy. Based on the separations between the energy peak positions of the FX emission lines, the identical PL decay kinetics among different FX emission lines, and the known phonon modes in h- BN, we suggest that there is only one principal emission line corresponding to the direct intrinsic FX transition in h- BN, whereas all other fine features are a result of phonon-assisted transitions. The identified phonon modes are all associated with the center of the Brillouin zone. Our results offer a simple picture for the understanding of the fundamental exciton transitions in h -BN.
    Print ISSN: 0003-6951
    Electronic ISSN: 1077-3118
    Topics: Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 5
    Publication Date: 2018-05-24
    Description: The subunit of bacterial RNA polymerase (RNAP) controls recognition of the –10 and –35 promoter elements during transcription initiation. Free adopts a "closed," or inactive, conformation incompatible with promoter binding. The conventional two-state model of activation proposes that binding to core RNAP induces formation of an "open," active, conformation, which is optimal for promoter recognition. Using single-molecule Förster resonance energy transfer, we demonstrate that vegetative-type subunits exist in open and closed states even after binding to the RNAP core. As an extreme case, RNAP from Mycobacterium tuberculosis preferentially retains in the closed conformation, which is converted to the open conformation only upon binding by the activator protein RbpA and interaction with promoter DNA. These findings reveal that the conformational dynamics of the subunit in the RNAP holoenzyme is a target for regulation by transcription factors and plays a critical role in promoter recognition.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 6
    Publication Date: 2019
    Description: 〈span〉〈div〉ABSTRACT〈/div〉The Fengcheng Formation is a nonmarine, carbonate-dominated succession that formed under arid climatic conditions in a hydrologically closed basin. Two transects and two seismic profiles were examined, the characteristics and environmental significance of different lithofacies were studied, and a model of depositional environment divisions was proposed. The sedimentary model involved an alkaline lake in which the depositional environments consisted of a shallow saline lake margin, slope, saline lake center, and steep lake margin from northeast to southwest. The perennial central salty lake was located in the southwestern part of the study area, whereas there were widespread, low-gradient lake margins in the northeast, east, southeast, and southern parts of the study area. Lake-level fluctuations had a major influence on the shallow saline lake system and complicated the depositional environments in these areas. The deposits are derived from bedrock reworking, volcanic eruptions, and authigenic minerals that precipitated from brine during the hypersaline phase. Fine-grained terrigenous clastic sediments, volcanic ashes and dusts, and authigenic minerals mixed in the depocenter (concentration center of the brine pool), which was covered by high-salinity brines, and the depositional environment was anoxic as a result of salinity-based brine stratification. A thick sodium carbonate succession occurred in the depocenter of the ancient Mahu lake, where bedded sodium carbonate alternated with fine-grained, organic-rich tuff or tuffaceous hydrocarbon source rocks. Microorganisms bloomed in the alkaline, high-salinity brine, and the organic matter was well preserved, which is similar to those modern alkaline saline lakes in eastern Africa and western North America. Thus, the Permian Fengcheng Formation contains source rocks that formed in an alkaline saline lake.〈/span〉
    Print ISSN: 0149-1423
    Electronic ISSN: 1943-2674
    Topics: Geosciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 7
    Publication Date: 2017-02-16
    Description: It is widely acknowledged that the growth and linkage of a boundary fault affects the evolution of the accompanying sedimentary basin and exerts a strong influence on its sedimentary characteristics. In this study, we attempt to discuss the evolution of a boundary fault and rift basin by using seismic interpretation, incremental fault throw, and growth rate–distance (G–d) profile, which are more suitable parameters than the expansion index in rift basins where footwall strata are missing because of erosion or a depositional hiatus. Therefore, the Gaoyou depression is taken as an example. The Gaoyou depression is the largest hydrocarbon-bearing depression in the Subei Basin, which is a representative rift basin in eastern China. The depression is bounded to the south by the Jiangdu–Wubao fault zone, which includes the Zhen 1–Wu 1, Zhen 2, and Wu 2 faults. Using high-resolution, three-dimensional seismic data, the Zhen 1–Wu 1 fault can be subdivided into four segments based on its G–d profile: the Shaobo, Fanchuan, Liuwushe, and Liulu segments. Growth rates indicate that the Zhen 1–Wu 1 fault and the Zhen 2 and Wu 2 faults developed successively from the Late Cretaceous to the Miocene during rifting of the Gaoyou depression and that development of the Zhen 2 and Wu 2 faults was controlled by the Zhen 1–Wu 1 fault. The four segments of the Zhen 1–Wu 1 fault were linked with each other by the time the Zhen 2 and Wu 2 faults formed in the Late Paleocene. An evolution model of the Gaoyou depression is set up in this study. Integrating the fault activity with previous sedimentological studies, we suggest that the evolution of the Gaoyou depression was controlled by the Jiangdu–Wubao fault zone rather than by a single fault. Successive slip of the Zhen 1–Wu 1 fault and the Zhen 2 and Wu 2 faults caused subsidence and migration of the depocenters. This study presents a case investigation of the effects of boundary faults on rift basins in eastern China.
    Print ISSN: 0149-1423
    Electronic ISSN: 0149-1423
    Topics: Geosciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 8
    Publication Date: 2017-03-25
    Description: Solute carrier family 12 member 5 promotes tumor invasion/metastasis of bladder urothelial carcinoma by enhancing NF-κB/MMP-7 signaling pathway Cell Death and Disease 8, e2691 (March 2017). doi:10.1038/cddis.2017.118 Authors: J Y Liu, Y B Dai, X Li, K Cao, D Xie, Z T Tong, Z Long, H Xiao, M K Chen, Y L Ye, B Liu, J Tan, J Tang, Z Z Xu, Y Gan, Y H Zhou, F Deng & L Y He
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 9
    Publication Date: 2017-05-27
    Description: The molecular motor exploited by bacteriophage 29 to pack DNA into its capsid is regarded as one of the most powerful mechanical devices present in viral, bacterial, and eukaryotic systems alike. Acting as a linker element, a prohead RNA (pRNA) effectively joins the connector and ATPase (adenosine triphosphatase) components of the 29 motor. During DNA packing, this pRNA needs to withstand enormous strain along the capsid’s portal axis—how this remarkable stability is achieved remains to be elucidated. We investigate the mechanical properties of the 29 motor’s three-way junction (3WJ)–pRNA using a combined steered molecular dynamics and atomic force spectroscopy approach. The 3WJ exhibits strong resistance to stretching along its coaxial helices, demonstrating its super structural robustness. This resistance disappears, however, when external forces are applied to the transverse directions. From a molecular standpoint, we demonstrate that this direction-dependent stability can be attributed to two Mg clamps that cooperate and generate mechanical resistance in the pRNA’s coaxial direction. Our results suggest that the asymmetric nature of the 3WJ’s mechanical stability is entwined with its biological function: Enhanced rigidity along the portal axis is likely essential to withstand the strain caused by DNA condensation, and flexibility in other directions should aid in the assembly of the pRNA and its association with other motor components.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 10
    Publication Date: 2017-01-10
    Description: As an extension of the conventional quantitative structure activity relationship models, proteochemometric (PCM) modelling is a computational method that can predict the bioactivity relations between multiple ligands and multiple targets. Traditional PCM modelling includes three essential elements: descriptors (including target descriptors, ligand descriptors and cross-term descriptors), bioactivity data and appropriate learning functions that link the descriptors to the bioactivity data. Since its appearance, PCM modelling has developed rapidly over the past decade by taking advantage of the progress of different descriptors and machine learning techniques, along with the increasing amounts of available bioactivity data. Specifically, the new emerging target descriptors and cross-term descriptors not only significantly increased the performance of PCM modelling but also expanded its application scope from traditional protein–ligand interaction to more abundant interactions, including protein–peptide, protein–DNA and even protein–protein interactions. In this review, target descriptors and cross-term descriptors, as well as the corresponding application scope, are intensively summarized. Additionally, we look forward to seeing PCM modelling extend into new application scopes, such as Target-Catalyst-Ligand systems, with the further development of descriptors, machine learning techniques and increasing amounts of available bioactivity data.
    Print ISSN: 1467-5463
    Electronic ISSN: 1477-4054
    Topics: Biology , Computer Science
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...