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  • 2015-2019  (580)
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  • 1
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    Marine biological materials of invertebrate origin (2019)
    Cham : Springer
    Details
    Call number: 9783319924830 (e-book)
    Description / Table of Contents: The work is a source of modern knowledge on biomineralization, biomimetics and bioinspired materials science with respect to marine invertebrates. The author gives the most coherent analysis of the nature, origin and evolution of biocomposites and biopolymers isolated from and observed in the broad diversity of marine invertebrate organisms and within their unusual structural formations. The basic format is that of a major review article, with liberal use of references to original literature. There is a wealth of new and newly synthesized information, including dozens of previously unpublished images of unique marine creatures and structures from nano- to microscale including high-resolution scanning and transmission electron micrographs. The material is organized effectively along both biological (phyla) and functional lines. The classification of biological materials of marine origin is proposed and discussed. Much of the pertinent data is organized into tables, and extensive use is made of electron micrographs and line drawings. Several modern topics e.g. “biomineralization- demineralization-remineralization phenomena”, or “phenomenon of multiphase biomineralization”, are discussed in details. Traditionally, such current concepts as hierarchical organization of biocomposites and skeletal structures, structural bioscaffolds, biosculpturing, biomimetism and bioinspiration as tools for the design of innovative materials are critically analyzed from both biological and materials science point of view using numerous unique examples of marine origin. This monograph reviews the most relevant advances in the marine biomaterials research field, pointing out several approaches being introduced and explored by distinct laboratories
    Type of Medium: 12
    Pages: 1 Online-Ressource (xiii, 329 Seiten) , Illustrationen
    ISBN: 9783319924830 , 978-3-319-92483-0
    ISSN: 2211-0607 , 2211-0593
    Series Statement: Biologically-inspired systems volume 13
    URL: Ebook (access only within the AWI network)
    DOI: 10.1007/978-3-319-92483-0
    Language: English
    Note: Contents Part I Biomaterials 1 Biomaterials and Biological Materials 1.1 Definitions and History: Biomaterial and Biological Material 1.2 Classification of Biomaterials 1.3 Conclusions References Part II Biomineralization and Biominerals 2 Biominerals 2.1 Biominerals of Marine Invertebrates Origin 2.1.1 Calcium-Based Biominerals 2.1.2 Magnesium-Based Biominerals 2.1.3 Barite-Based Biominerals 2.1.4 Fe-Based Biominerals 2.1.5 Vanadium (Biomineral?) 2.1.6 Strontium-Based Biominerals 2.1.7 Boron 2.1.8 Titanium-Based Biominerals 2.1.9 Copper-Based Biominerals 2.1.10 Zinc-Based Biominerals 2.1.11 Manganese Oxides 2.1.12 Germanium-Based Biominerals 2.1.13 Silica-Based Biominerals 2.2 Conclusion References 3 Biomineralization 3.1 Conclusion References 4 The Circle: Biomineralization - Demineralization - Remineralization in Nature 4.1 Principles of Demineralization: Isolation of Organic Matter 4.2 Conclusion References Part III Biocomposites and Biomineralized Structures 5 Hierarchical Biological Materials 5.1 Cellular Structures 5.2 Honeycomb Matrices 5.3 Siliceous Honeycombs in Diatoms 5.4 Conclusion References 6 Paleodyction- Enigmatic Honeycomb Structure 6.1 Conclusion References 7 Sponge Biosilica- Perfectionism in Glass 7.1 Glass Sponges (Hexactinellida) 7.2 Demosponges (Demospongiae) 7.3 Lithistid Sponges 7.4 Cellular Structures in Glass Sponges 7.5 Spiculogenesis 7.5.1 Chitin- and Collagen-Based Silicification Versus Silicatein- Based Way 7.6 Conclusion References 8 Interspace Mineralization Within Bilayered Organic Matrix of Deep-Sea Bamboo Coral (Anthozoa: Gorgonacea: Isididae) 8.1 Conclusion References 9 Living Bone Implants of Bamboo Corals Origin 9.1 Conclusion References 10 Spicular Structures in Molluscs 10.1 Spicules of Nudibranchia 10.2 Spicules in Aplacophora 10.3 Spicules in Polyplacophora (Chitons) 10.4 Onchidiella Spicules 10.5 Conclusion References Part IV Non-mineralized Structures 11 Enigmatic Structural Protein Spongin 11.1 Spongin as a Halogenated Scleroprotein 11.2 Spongin as a Collagenous Protein 11.2.1 The Basal Spongin 11.3 Role of Spongins in Natural Environments 11.4 Mechanical Properties of Spongin-Based Skeletons 11.5 Spongin as a Three Dimensional Scaffold for Tissue Engineering 11.6 Conclusion References 12 Gorgonin 12.1 Introduction into the History and Chemistry of Gorgonin 12.2 Mechanical Properties of Gorgonin-Based Skeletons 12.3 Gorgonin-Based Skeletons and Paleooceanographic Dynamics 12.4 Conclusion References 13 Antipathin 13.1 Brief Introduction in to Antipatharia 13.2 Chemistry of Black Corals 13.3 Material Properties of Antipathin-Based Skeletons 13.4 Conclusion References 14 Rubber-Like Bioelastomers of Marine Origin 14.1 Hinge Ligament 14.2 Chemistry of the Hinge Ligament 14.3 Structural Features of Hinge Ligaments 14.4 Conclusion References 15 Capsular Bioelastomers of Whelks 15.1 Conclusion References 16 Byssus: From Inspiration to Development of Novel Composites 16.1 Byssus: An Ancient Marine Biological Material 16.2 Why Molluscs Produce Different Kinds of Byssus 16.3 Chemistry of Byssus and Related Proteins 16.3.1 (mefp-2) Mytilus Edulis Adhesive Protein-2 16.3.2 (mefp-3) Mytilus edulis Adhesive Protein-3 16.3.3 (mefp-4) Mytilus Edulis Adhesive Protein-4 16.3.4 (mefp-5) Mytilus edulis Adhesive Protein-5 16.4 Biomechanics and Materials Properties of Byssus 16.5 Conclusion References 17 Abductin 17.1 Conclusion References 18 Resilin 18.1 Conclusion References 19 Adhesion Systems in Echinodermata 19.1 Sea Urchins 19.2 Sea Cucumbers 19.3 Sea Stars 19.4 Conclusion References 20 Adhesive Gels of Marine Gastropods (Mollusca) Origin 20.1 Conclusion References 21 Biocements 21.1 Barnacles: Crustaceans That Mimic Molluscs 21.2 “First-Kiss” Adhesion Behaviour in Barnacles 21.3 Barnacles Cements 21.4 Conclusion References 22 Halogenated Biocomposites 22.1 Polychaetes Jaws 22.2 Crustaceans Alternative Cuticles 22.3 Conclusion References 23 Chitin-Protein-Based Composites 23.1 The Highly Flexible Setae of Hairy Lobster Kiwa hirsuta 23.2 Shinkaia Crosnieri 23.3 Structural Features of Eriocheir sinensis Setae 23.4 Conclusion References Part V Macromolecular Biopolymers 24 Chitin 24.1 Chitinous Scaffolds of Marine Sponges Origin 24.2 Biological Features of Chitin 24.3 Chitin Scaffolds for Application in Tissue Engineering 24.4 Conclusion References 25 Collagens from Marine Invertebrates 25.1 Poriferan Collagens 25.2 Coelenterates Collagens 25.3 Molluscs Collagens 25.4 Echinoderm Collagens 25.5 Conclusion References Part VI From Extreme Biomineralization to Extreme Biomimetics 26 Extreme Biomimetics 26.1 Templates for Extreme Biomimetics 26.2 Conclusion References 27 Epiloque 27.1 Biomedicine and Bioengineering 27.2 Marine Biomaterials and Microplastic References Index
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  • 2
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    Anti-Tumorigenic and Anti-Metastatic Activity of the Sponge-Derived Marine Drugs Aeroplysinin-1 and Isofistularin-3 against Pheochromocytoma In Vitro (2018)
    Molecular Diversity Preservation International
    Details
    Publication Date: 2018-05-20
    Electronic ISSN: 1660-3397
    Topics: Chemistry and Pharmacology
    Published by Molecular Diversity Preservation International
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  • 3
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    Genome rearrangements induce biofilm formation in Escherichia coli C – an old model organism with a new application in biofilm research (2019)
    BioMed Central
    Details
    Publication Date: 2019-10-22
    Description: Background Escherichia coli C forms more robust biofilms than other laboratory strains. Biofilm formation and cell aggregation under a high shear force depend on temperature and salt concentrations. It is the last of five E. coli strains (C, K12, B, W, Crooks) designated as safe for laboratory purposes whose genome has not been sequenced. Results Here we present the complete genomic sequence of this strain in which we utilized both long-read PacBio-based sequencing and high resolution optical mapping to confirm a large inversion in comparison to the other laboratory strains. Notably, DNA sequence comparison revealed the absence of several genes thought to be involved in biofilm formation, including antigen 43, waaSBOJYZUL for lipopolysaccharide (LPS) synthesis, and cpsB for curli synthesis. The first main difference we identified that likely affects biofilm formation is the presence of an IS3-like insertion sequence in front of the carbon storage regulator csrA gene. This insertion is located 86 bp upstream of the csrA start codon inside the − 35 region of P4 promoter and blocks the transcription from the sigma32 and sigma70 promoters P1-P3 located further upstream. The second is the presence of an IS5/IS1182 in front of the csgD gene. And finally, E. coli C encodes an additional sigma70 subunit driven by the same IS3-like insertion sequence. Promoter analyses using GFP gene fusions provided insights into understanding this regulatory pathway in E. coli. Conclusions Biofilms are crucial for bacterial survival, adaptation, and dissemination in natural, industrial, and medical environments. Most laboratory strains of E. coli grown for decades in vitro have evolved and lost their ability to form biofilm, while environmental isolates that can cause infections and diseases are not safe to work with. Here, we show that the historic laboratory strain of E. coli C produces a robust biofilm and can be used as a model organism for multicellular bacterial research. Furthermore, we ascertained the full genomic sequence of this classic strain, which provides for a base level of characterization and makes it useful for many biofilm-based applications.
    Electronic ISSN: 1471-2164
    Topics: Biology
    Published by BioMed Central
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  • 4
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    Data showing atherosclerosis-associated differentially methylated regions are often at enhancers (2019)
    Elsevier
    Details
    Publication Date: 2019-04-01
    Electronic ISSN: 2352-3409
    Topics: Biology
    Published by Elsevier
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  • 5
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    Long-term declines in bird populations in tropical agricultural countryside (2019)
    National Academy of Sciences
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    Publication Date: 2019-04-29
    Description: Tropical agriculture is a major driver of biodiversity loss, yet it can provide conservation opportunities, especially where protected areas are inadequate. To investigate the long-term biodiversity capacity of agricultural countryside, we quantified bird population trends in Costa Rica by mist netting 57,255 birds of 265 species between 1999 and 2010 in sun coffee plantations, riparian corridors, secondary forests, forest fragments, and primary forest reserves. More bird populations (69) were declining than were stable (39) or increasing (4). Declines were common in resident, insectivorous, and more specialized species. There was no relationship between the species richness of a habitat and its conservation value. High-value forest bird communities were characterized by their distinct species composition and habitat and dietary functional signatures. While 49% of bird species preferred forest to coffee, 39% preferred coffee to forest and 12% used both habitats, indicating that coffee plantations have some conservation value. Coffee plantations, although lacking most of the forest specialists, hosted 185 bird species, had the highest capture rates, and supported increasing numbers of some forest species. Coffee plantations with higher tree cover (7% vs. 13%) had more species with increasing capture rates, twice as many forest specialists, and half as many nonforest species. Costa Rican countryside habitats, especially those with greater tree cover, host many bird species and are critical for connecting bird populations in forest remnants. Diversified agricultural landscapes can enhance the biodiversity capacity of tropical countryside, but, for the long-term persistence of all forest bird species, large (〉1,000 ha) protected areas are essential.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 6
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    Nucleosomal arrangement affects single-molecule transcription dynamics (2016)
    National Academy of Sciences
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    Publication Date: 2016-10-24
    Description: In eukaryotes, gene expression depends on chromatin organization. However, how chromatin affects the transcription dynamics of individual RNA polymerases has remained elusive. Here, we use dual trap optical tweezers to study single yeast RNA polymerase II (Pol II) molecules transcribing along a DNA template with two nucleosomes. The slowdown and the changes in pausing behavior within the nucleosomal region allow us to determine a drift coefficient, χ, which characterizes the ability of the enzyme to recover from a nucleosomal backtrack. Notably, χ can be used to predict the probability to pass the first nucleosome. Importantly, the presence of a second nucleosome changes χ in a manner that depends on the spacing between the two nucleosomes, as well as on their rotational arrangement on the helical DNA molecule. Our results indicate that the ability of Pol II to pass the first nucleosome is increased when the next nucleosome is turned away from the first one to face the opposite side of the DNA template. These findings help to rationalize how chromatin arrangement affects Pol II transcription dynamics.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 7
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    Deletion of the mu opioid receptor gene in mice reshapes the reward–aversion connectome (2016)
    National Academy of Sciences
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    Publication Date: 2016-09-26
    Description: Connectome genetics seeks to uncover how genetic factors shape brain functional connectivity; however, the causal impact of a single gene’s activity on whole-brain networks remains unknown. We tested whether the sole targeted deletion of the mu opioid receptor gene (Oprm1) alters the brain connectome in living mice. Hypothesis-free analysis of combined resting-state fMRI diffusion tractography showed pronounced modifications of functional connectivity with only minor changes in structural pathways. Fine-grained resting-state fMRI mapping, graph theory, and intergroup comparison revealed Oprm1-specific hubs and captured a unique Oprm1 gene-to-network signature. Strongest perturbations occurred in connectional patterns of pain/aversion-related nodes, including the mu receptor-enriched habenula node. Our data demonstrate that the main receptor for morphine predominantly shapes the so-called reward/aversion circuitry, with major influence on negative affect centers.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 8
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    Structure of xyloglucan xylosyltransferase 1 reveals simple steric rules that define biological patterns of xyloglucan polymers (2018)
    National Academy of Sciences
    Details
    Publication Date: 2018-05-21
    Description: The plant cell wall is primarily a polysaccharide mesh of the most abundant biopolymers on earth. Although one of the richest sources of biorenewable materials, the biosynthesis of the plant polysaccharides is poorly understood. Structures of many essential plant glycosyltransferases are unknown and suitable substrates are often unavailable for in vitro analysis. The dearth of such information impedes the development of plants better suited for industrial applications. Presented here are structures of Arabidopsis xyloglucan xylosyltransferase 1 (XXT1) without ligands and in complexes with UDP and cellohexaose. XXT1 initiates side-chain extensions from a linear glucan polymer by transferring the xylosyl group from UDP-xylose during xyloglucan biosynthesis. XXT1, a homodimer and member of the GT-A fold family of glycosyltransferases, binds UDP analogously to other GT-A fold enzymes. Structures here and the properties of mutant XXT1s are consistent with a SNi-like catalytic mechanism. Distinct from other systems is the recognition of cellohexaose by way of an extended cleft. The XXT1 dimer alone cannot produce xylosylation patterns observed for native xyloglucans because of steric constraints imposed by the acceptor binding cleft. Homology modeling of XXT2 and XXT5, the other two xylosyltransferases involved in xyloglucan biosynthesis, reveals a structurally altered cleft in XXT5 that could accommodate a partially xylosylated glucan chain produced by XXT1 and/or XXT2. An assembly of the three XXTs can produce the xylosylation patterns of native xyloglucans, suggesting the involvement of an organized multienzyme complex in the xyloglucan biosynthesis.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 9
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    Endogenous dendritic cells from the tumor microenvironment support T-ALL growth via IGF1R activation (2016)
    National Academy of Sciences
    Details
    Publication Date: 2016-02-09
    Description: Primary T-cell acute lymphoblastic leukemia (T-ALL) cells require stromal-derived signals to survive. Although many studies have identified cell-intrinsic alterations in signaling pathways that promote T-ALL growth, the identity of endogenous stromal cells and their associated signals in the tumor microenvironment that support T-ALL remains unknown. By examining the thymic tumor microenvironments in multiple murine T-ALL models and primary patient samples, we discovered the emergence of prominent epithelial-free regions, enriched for proliferating tumor cells and dendritic cells (DCs). Systematic evaluation of the functional capacity of tumor-associated stromal cells revealed that myeloid cells, primarily DCs, are necessary and sufficient to support T-ALL survival ex vivo. DCs support T-ALL growth both in primary thymic tumors and at secondary tumor sites. To identify a molecular mechanism by which DCs support T-ALL growth, we first performed gene expression profiling, which revealed up-regulation of platelet-derived growth factor receptor beta (Pdgfrb) and insulin-like growth factor I receptor (Igf1r) on T-ALL cells, with concomitant expression of their ligands by tumor-associated DCs. Both Pdgfrb and Igf1r were activated in ex vivo T-ALL cells, and coculture with tumor-associated, but not normal thymic DCs, sustained IGF1R activation. Furthermore, IGF1R signaling was necessary for DC-mediated T-ALL survival. Collectively, these studies provide the first evidence that endogenous tumor-associated DCs supply signals driving T-ALL growth, and implicate tumor-associated DCs and their mitogenic signals as auspicious therapeutic targets.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 10
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    Reply to Kirchhoff: Homogenous and mutually exclusive conservation typologies are neither possible nor desirable (2015)
    National Academy of Sciences
    Details
    Publication Date: 2015-10-19
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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