Publication Date:
2015-07-25
Description:
Article Receptor tyrosine kinases are key mediators of cell proliferation that have been implicated in several disease states for which they represent promising drug targets. Here the authors determine the thermodynamic basis for the low propensity of FGFR1 to access the DFG-Phe-out conformation required to bind type-II inhibitors. Nature Communications doi: 10.1038/ncomms8877 Authors: Tobias Klein, Navratna Vajpai, Jonathan J. Phillips, Gareth Davies, Geoffrey A. Holdgate, Chris Phillips, Julie A. Tucker, Richard A. Norman, Andrew D. Scott, Daniel R. Higazi, David Lowe, Gary S. Thompson, Alexander L. Breeze
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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