Electronic Resource
Palo Alto, Calif.
:
Annual Reviews
Annual Review of Cell and Developmental Biology
12 (1996), S. 463-519
ISSN:
1081-0706
Source:
Annual Reviews Electronic Back Volume Collection 1932-2001ff
Topics:
Biology
,
Medicine
Notes:
Abstract Focal adhesions are sites of tight adhesion to the underlying extracellular matrix developed by cells in culture. They provide a structural link between the actin cytoskeleton and the extracellular matrix and are regions of signal transduction that relate to growth control. The assembly of focal adhesions is regulated by the GTP-binding protein Rho. Rho stimulates contractility which, in cells that are tightly adherent to the substrate, generates isometric tension. In turn, this leads to the bundling of actin filaments and the aggregation of integrins (extracellular matrix receptors) in the plane of the membrane. The aggregation of integrins activates the focal adhesion kinase and leads to the assembly of a multicomponent signaling complex.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1146/annurev.cellbio.12.1.463
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