Publication Date:
2018-01-26
Description:
Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease Endothelial deletion of 〈i〉Ino80〈/i〉 disrupts coronary angiogenesis and causes congenital heart disease, Published online: 25 January 2018; doi:10.1038/s41467-017-02796-3 Heart development requires compaction of the ventricular wall into a dense myocardium at mid-gestation. Here, Rhee and colleagues show that the chromatin remodeller Ino80 is critical for the formation of the coronary vasculature, and show that coronary vessels are needed for successful cardiac compaction during embryonic development.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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