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  • Extraterrestrial Environment  (1)
  • biological activitydiaryliodonium saltfluorinehypervalent iodinelymphomapentafluorosulfanyl  (1)
  • 2015-2019  (2)
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  • 2015-2019  (2)
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  • 1
    Publication Date: 2018-03-06
    Description: Conscious of the potential bioactivity of fluorine, an investigation was conducted using various fluorine-containing diaryliodonium salts in order to study and compare their biological activity against human lymphoma U937 cells. Most of the compounds tested are well-known reagents for fluoro-functionalized arylation reactions in synthetic organic chemistry, but their biological properties are not fully understood. Herein, after initially investigating 18 fluoro-functionalized reagents, we discovered that the ortho -fluoro-functionalized diaryliodonium salt reagents showed remarkable cytotoxicity in vitro. These results led us to synthesize more compounds, previously unknown sterically demanding diaryliodonium salts having a pentafluorosulfanyl (SF 5 ) functional group at the ortho -position, that is, unsymmetrical ortho -SF 5 phenylaryl-λ 3 -iodonium salts. Newly synthesized mesityl(2-(pentafluoro-λ 6 -sulfanyl)phenyl)iodonium exhibited the greatest potency in vitro against U937 cells. Evaluation of the cytotoxicity of selected phenylaryl-λ 3 -iodonium salts against AGLCL (a normal human B cell line) was also examined. Beilstein J. Org. Chem. 2018, 14, 364–372. doi:10.3762/bjoc.14.24
    Keywords: biological activitydiaryliodonium saltfluorinehypervalent iodinelymphomapentafluorosulfanyl
    Electronic ISSN: 1860-5397
    Topics: Chemistry and Pharmacology
    Published by Beilstein-Institut
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  • 2
    Publication Date: 2015-03-07
    Description: We measured maps of atmospheric water (H2O) and its deuterated form (HDO) across the martian globe, showing strong isotopic anomalies and a significant high deuterium/hydrogen (D/H) enrichment indicative of great water loss. The maps sample the evolution of sublimation from the north polar cap, revealing that the released water has a representative D/H value enriched by a factor of about 7 relative to Earth's ocean [Vienna standard mean ocean water (VSMOW)]. Certain basins and orographic depressions show even higher enrichment, whereas high-altitude regions show much lower values (1 to 3 VSMOW). Our atmospheric maps indicate that water ice in the polar reservoirs is enriched in deuterium to at least 8 VSMOW, which would mean that early Mars (4.5 billion years ago) had a global equivalent water layer at least 137 meters deep.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Villanueva, G L -- Mumma, M J -- Novak, R E -- Kaufl, H U -- Hartogh, P -- Encrenaz, T -- Tokunaga, A -- Khayat, A -- Smith, M D -- New York, N.Y. -- Science. 2015 Apr 10;348(6231):218-21. doi: 10.1126/science.aaa3630. Epub 2015 Mar 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉NASA Goddard Space Flight Center, Greenbelt, MD 20771, USA. Catholic University of America, Washington, DC 20064, USA. geronimo.villanueva@nasa.gov. ; NASA Goddard Space Flight Center, Greenbelt, MD 20771, USA. ; Iona College, New Rochelle, NY 10801, USA. ; European Southern Observatory, Munich, Germany. ; Max Planck Institute for Solar System Research, Katlenburg-Lindau 37191, Germany. ; Observatoire de Paris-Meudon, Meudon 92195, France. ; University of Hawaii-Manoa, Honolulu, HI 96822, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25745065" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere ; Deuterium/analysis ; Deuterium Oxide ; Evolution, Planetary ; Extraterrestrial Environment ; Ice ; *Mars ; *Water
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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