Publication Date:
2017-05-04
Description:
The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability Nature 545, 7652 (2017). doi:10.1038/nature22082 Authors: Timothy S. Luongo, Jonathan P. Lambert, Polina Gross, Mary Nwokedi, Alyssa A. Lombardi, Santhanam Shanmughapriya, April C. Carpenter, Devin Kolmetzky, Erhe Gao, Jop H. van Berlo, Emily J. Tsai, Jeffery D. Molkentin, Xiongwen Chen, Muniswamy Madesh, Steven R. Houser & John W. Elrod Mitochondrial calcium (mCa2+) has a central role in both metabolic regulation and cell death signalling, however its role in homeostatic function and disease is controversial. Slc8b1 encodes the mitochondrial Na+/Ca2+ exchanger (NCLX), which is proposed
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
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Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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