ALBERT

Description: Objective: To perform a systematic review (SR) of existing literature and a patent landscape report (PLR) regarding the potential applications of shape-memory polymers (SMPs) in dentistry. Search strategy: Clinical and Biomedical online databases (Pubmed, Medline via Embase, Scopus, LILACS, Web of Science, Cochrane Library), Materials Science and Engineering databases (IEEE Explore, Compendex, Proquest), Material Science and Chemical database (Reaxys) so as Patents databases (Questel-Orbit, Espacenet, Patentscope) were consulted as recently as January 2019 to identify all papers and patents potentially relevant to the review. The reference lists of all eligible studies were hand searched for additional published work. Results: After duplicate selection and extraction procedures, 6 relevant full-text articles from the initial 302 and 45 relevant patents from 497 were selected. A modified Consolidated Standards of Reporting Trials (CONSORT) checklist of 14 items for reporting pre-clinical in-vitro studies was used to rate the methodological quality of the selected papers. The overall quality was judged low. Conclusions: Despite the great potential and versatility of SMPs, it was not possible to draw evidence-based conclusions supporting their immediate employment in clinical dentistry. This was due to the weak design and a limited number of studies included within this review and reflects the fact that additional research is mandatory to determine whether or not the use of SMPs in dentistry could be effective. Nevertheless, the qualitative analysis of selected papers and patents indicate that SMPs are promising materials in dentistry because of their programmable physical properties. These findings suggest the importance of furtherly pursuing this line of research.

Description: The improvement of the readability of time-frequency transforms is an important topic in the field of fast-oscillating signal processing. The reassignment method is often used due to its adaptivity to different transforms and nice formal properties. However, it strongly depends on the selection of the analysis window and it requires the computation of the same transform using three different but well-defined windows. The aim of this work is to provide a simple method for spectrogram reassignment, named FIRST (Fast Iterative and Robust Reassignment Thinning), with comparable or better precision than classical reassignment method, a reduced computational effort, and a near independence of the adopted analysis window. To this aim, the time-frequency evolution of a multicomponent signal is formally provided and, based on this law, only a subset of time-frequency points is used to improve spectrogram readability. Those points are the ones less influenced by interfering components. Preliminary results show that the proposed method can efficiently reassign spectrograms more accurately than the classical method in the case of interfering signal components, with a significant gain in terms of required computational effort.

Description: Abstract Despite the importance of shallow lakes worldwide, knowledge of microbial components, the base of their food webs, remains scarce. To close this gap, we investigated planktonic microbial food webs, in particular protistan bacterivory (for both ciliates and heterotrophic nanoflagellates [HNF]), in 10 shallow hypertrophic fishponds in South Bohemia (Czech Republic). We used fluorescently labeled bacteria as bacterivory tracers to estimate how abundant protistan populations in fishponds (4–25 × 103 HNF mL−1 and 55–770 ciliates mL−1) contribute to total bacterial mortality. Fluorescence microscopy, innovative image processing tools, and quantitative protargol staining were combined to detect major bacterivorous and omnivorous ciliate taxa. We quantified bacterial production, bacterivory by individual ciliate species, total ciliates, and total protistan bacterivory in all fishponds. On average, ciliate bacterivory was comparable to that of HNF, accounting for 56% and 44% of total protistan grazing, respectively. We found that primarily bacterivorous Peritrichia (genera Vorticella, Epistylis) and Scuticociliata (Cyclidium spp.) contributed only moderately (mean 26%) to total ciliate bacterivory. Unexpectedly, but highly abundant omnivorous Halteria/Pelagohalteria (Stichotrichia) and, to a lesser extent, also omnivorous Rimostrombidium spp. (Oligotrichia) contributed significantly more (mean 71%) to total ciliate bacterivory than typical bacterivorous taxa. This suggests that unselective grazers, which feed on a broader size spectrum from bacteria to small algae, may have a considerable competitive advantage in hypertrophic environments rich in small particles. Moreover, a meta‐analysis of available literature data supports our hypothesis that the role of ciliate bacterivory increases significantly, relative to HNF bacterivory, along a trophic gradient toward hypertrophic habitats.

Description: Knowing how the ambient medium in the vicinity of active galactic nuclei (AGNs) is shaped is crucial to understanding generally the evolution of such cosmic giants as well as AGN jet formation and launching. Thanks to the new broadband capability now available at the Jansky Very Large Array (JVLA), we can study changes in polarization properties, fractional polarization, and polarization angles, together with the total intensity spectra of a sample of 14 AGNs, within a frequency range from 1 to 12 GHz. Depolarization modeling has been performed by means of so-called “qu-fitting” to the polarized data, and a synchrotron self absorption model has been used for fitting to the total intensity data. We found complex behavior both in the polarization spectra and in the total intensity spectra, and several Faraday components with a large rotation measure (RM) and several synchrotron components were needed to represent these spectra. Here, results for three targets are shown. This new method of analyzing broadband polarization data through qu-fitting successfully maps the complex surroundings of unresolved objects.

Description: Understanding the genetic background of complex behavioral traits, showing multigenic control and extensive environmental effects, is a challenging task. Among such traits, migration is known to show a large additive genetic component. Yet, the identification of specific genes or gene regions explaining phenotypic variance in migratory behavior has received less attention. Migration ultimately depends on seasonal cycles, and polymorphism at phenological candidate genes may underlie variation in timing of migration or other aspects of migratory behavior. In this study of a Nearctic–Neotropical migratory songbird, the Wilson's warbler ( Cardellina pusilla ), we investigated the association between polymorphism at two phenological candidate genes, Clock and Adcyap1 , and two aspects of the migratory phenotype, timing of spring migration through a stopover site and inferred latitude of the breeding destination. The breeding destination of migrating individuals was identified using feather deuterium ratio ( δ 2 H), which reliably reflects breeding latitude throughout the species' western breeding range. Ninety-eight percent of the individuals were homozygous at Clock , and the rare heterozygotes did not deviate from homozygous migration phenology. Adcyap1 was highly polymorphic, and allele size was not significantly associated with migration date. However, Adcyap1 allele size significantly positively predicted the inferred breeding latitude of males but not of females. Moreover, we found a strong positive association between inferred breeding latitude and Adcyap1 allele size in long-distance migrating birds from the northern sector of the breeding range (western Canada), while this was not the case in short-distance migrating birds from the southern sector of the breeding range (coastal California). Our findings support previous evidence for a role of Adcyap1 in shaping the avian migratory phenotype, while highlighting that patterns of phenological candidate gene–phenotype associations may be complex, significantly varying between geographically distinct populations and even between the sexes. We investigated whether genetic polymorphism at two migration-linked candidate genes, Clock and Adcyap1 , predicted phenotypic variation in timing of spring migration and breeding latitude in western populations of a Nearctic migratory songbird, the Wilson's warbler ( Cardellina pusilla ). While Clock was monomorphic, Adcyap1 allele size strongly ( r  = 0.69) predicted latitude of the breeding destination, inferred from stable isotope ratios of feathers, of long-distance, northern breeding populations (western Canada), while this was not the case ( r  = 0.12) among southern breeding birds (coastal California). We also found that Adcyap1 significantly covaried with inferred breeding latitude of males but not of females. No association was found between Adcyap1 allele size and spring migration timing. These findings are consistent with the hypothesis that Adcyap1 is involved in the regulation of migratory behavior.

Description: We present preliminary results of JVLA wideband full polarization observations of a sample of Active Galactic Nuclei (AGN) with very high Rotation Measure (RM) values, a sign of extreme environment. Polarization properties show a complex behaviour such that the polarization angle (PA) and fractional polarization (fp) change dramatically within the wide band. The measured RM is not constant within the wide band. Its complex behaviour reflects the complexity of the medium with the presence of several Faraday components. The depolarization has been studied by modelling the variations of the Stokes parameters Q and U together with the polarization parameters (PA and fp) with wavelength using combinations of the simplest existing depolarization models. With this JVLA study we could spectrally resolve multiple polarized components of unresolved AGN. These preliminary results reveal the complexity of these objects, but improvements to the depolarization modelling are needed to better understand the polarization structure of these sources.

Description: Galaxies, Vol. 6, Pages 40: Probing the Large Faraday Rotation Measure Environment of Compact Active Galactic Nuclei Galaxies doi: 10.3390/galaxies6020040 Authors: Alice Pasetto Carlos Carrasco-González Shane O’Sullivan Aritra Basu Gabriele Bruni Alex Kraus Salvador Curiel Karl-Heinz Mack Knowing how the ambient medium in the vicinity of active galactic nuclei (AGNs) is shaped is crucial to understanding generally the evolution of such cosmic giants as well as AGN jet formation and launching. Thanks to the new broadband capability now available at the Jansky Very Large Array (JVLA), we can study changes in polarization properties, fractional polarization, and polarization angles, together with the total intensity spectra of a sample of 14 AGNs, within a frequency range from 1 to 12 GHz. Depolarization modeling has been performed by means of so-called “qu-fitting” to the polarized data, and a synchrotron self absorption model has been used for fitting to the total intensity data. We found complex behavior both in the polarization spectra and in the total intensity spectra, and several Faraday components with a large rotation measure (RM) and several synchrotron components were needed to represent these spectra. Here, results for three targets are shown. This new method of analyzing broadband polarization data through qu-fitting successfully maps the complex surroundings of unresolved objects.

Description: Distributed FX-architecture (DiFX) is a software Very Long Baseline Interferometry (VLBI) correlator currently adopted by several main correlation sites around the globe. After the launch of the RadioAstron Space-VLBI mission in 2011, an extension was necessary to handle processing of an orbiting antenna, to be correlated with supporting ground arrays. Here, we present a branch of the main DiFX distribution (2.4), uploaded on the publicly available repository during July 2016, that the Max Planck Institute for Radio Astronomy (MPIfR) developed to process data of the three key active galactic nuclei (AGN)-imaging RadioAstron science projects, as well as part of the AGN survey project, and General Observing Time (GOT) projects proposed since Announcement of Opportunity 2 (AO-2, July 2014–July 2015). It can account for general relativistic correction of an orbiting antenna with variable position/velocity, providing a routine to convert the native RadioAstron Data Format (RDF) format to the more common Mark5 B (M5B). The possibility of introducing a polynomial clock allows one to mitigate the effects of spacecraft acceleration terms in near-perigee observations. Additionally, since for the first time polarimetry on space-baselines is available thanks to RadioAstron, this DiFX branch allows one to include the spacecraft orientation information at the correlation stage, in order to perform proper polarization calibration during data reduction. Finally, a fringe-finding algorithm able to manage an arbitrarily large fringe-search window is included, allowing one to increase the search space normally adopted by common software packages like HOPS.

Description: ABSTRACT In the central nervous system, cholesterol is critical to maintain membrane plasticity, cellular function, and synaptic integrity. In recent years, much attention was focused on the role of cholesterol in brain since a breakdown of cholesterol metabolism has been associated with different diseases. Brain-derived neurotrophic factor (BDNF) was previously reported to elicit cholesterol biosynthesis and promote the accumulation of presynaptic proteins in cholesterol-rich lipid rafts, but no data are available on its ability to modulate physiological mechanisms involved in cholesterol homeostasis. Major aim of this research was to investigate whether BDNF influences cholesterol homeostasis, focusing on the effect of the neurotrophin on Apolipoprotein E (ApoE) synthesis, cholesterol efflux from astrocytes and cholesterol incorporation into neurons. Our results show that BDNF significantly stimulates cholesterol efflux by astrocytes, as well as ATP binding cassette A1 (ABCA1) transporter and ApoE expression. Conversely, cholesterol uptake in neurons was downregulated by BDNF. This effect was associated with the increase of Liver X Receptor (LXR)-beta expression in neuron exposed to BDNF. The level of apoptosis markers, i.e. cleaved caspase 3 and poly ADP ribose polymerase (PARP), was found increased in neurons treated with high cholesterol, but significantly lower when the cells were exposed to cholesterol in the presence of BDNF, thus suggesting a neuroprotective role of the neurotrophin, likely through its reducing effect of neuronal cholesterol uptake. Interestingly, cholesterol stimulates BDNF production by neurons. Overall, our findings evidenced a novel role of BDNF in the modulation of ApoE and cholesterol homeostasis in glial and neuronal cells. This article is protected by copyright. All rights reserved