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  • Elsevier  (296)
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  • 1
    Publikationsdatum: 2015-07-07
    Beschreibung: Journal of Proteome Research DOI: 10.1021/acs.jproteome.5b00307
    Print ISSN: 1535-3893
    Digitale ISSN: 1535-3907
    Thema: Chemie und Pharmazie
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Publikationsdatum: 2019-03-12
    Beschreibung: © The Authors, 2019. This is the author's version of the work and is distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 4.0 International License. The definitive version was published in Marine Pollution Bulletin, 140, (2019):364-373, doi:10.1016/j.marpolbul.2018.12.047.
    Beschreibung: Estuaries provide significant cultural ecosystem services, including recreation and tourism. Disruptions of estuarine biogeochemical processes resulting from environmental degradation could interrupt the flow of these services, reducing benefits and diminishing the welfare of local communities. This study focused on recreational shellfishing in Buzzards Bay, Massachusetts (41.55°N, 70.80°W). Relationships among measures of recreational shellfishing, estuarine water quality, and local socioeconomic conditions were tested to understand how the benefits of cultural ecosystem services to local communities might be affected by declining water quality. Transferring estimated economic benefits from an analysis of nearby municipalities, the study finds that increases in Chl a during the 24-year period were associated with losses in recreational shellfishing benefits of $0.08–0.67 million per decade. The approach presented here suggests a more broadly applicable framework for assessing the impacts of changes in coastal ecosystem water quality on the welfare of local communities.
    Beschreibung: We would like to thank the Buzzards Bay Coalition, the Buzzards Bay National Estuary Program, and the Massachusetts Department of Marine Fisheries for providing data for this analysis. We thank the 1074 citizen volunteers of the Buzzards Bay Coalition who collected the water quality samples and Mark Rasmussen for his leadership in sustaining the Baywatchers Program. Support for this analysis was provided by the John D. and Catherine T. MacArthur Foundation (Grant no. 14-106159-000-CFP), MIT Sea Grant (subaward number 5710004045), the Johnson Endowment of the WHOI Marine Policy Center, and SCD acknowledges support from the University of Virginia.
    Schlagwort(e): Estuarine water quality ; Eutrophication ; Recreational shellfishing ; Cultural ecosystem services ; Economic benefits transfer
    Repository-Name: Woods Hole Open Access Server
    Materialart: Article
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Publikationsdatum: 2022-05-25
    Beschreibung: © The Author(s), 2013. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Journal of King Saud University - Science 25 (2013): 217–228, doi:10.1016/j.jksus.2013.02.006.
    Beschreibung: The degradation of natural fish habitat in the ocean implies lost economic benefits. These value losses often are not measured or anticipated fully, and therefore they are mainly ignored in decisions to develop the coast for industrial or residential purposes. In such circumstances, the ocean habitat and its associated ecosystem are treated as if they are worthless. Measures of actual or potential economic values generated by fisheries in commercial markets can be used to assess a conservative (lower-bound) value of ocean habitat. With this information, one can begin to compare the values of coastal developments to the values of foregone ocean habitat in order to help understand whether development would be justified economically. In this paper, we focus on the economic value associated with the harvesting of commercial fish stocks as a relevant case for the Saudi Arabian portion of the Red Sea. We describe first the conceptual basis behind supply-side approaches to economic valuation. Next we review the literature on the use of these methods for valuing ocean habitat. We provide an example based on recent research assessing the bioeconomic status of the traditional fisheries of the Red Sea in the Kingdom of Saudi Arabia (KSA). We estimate the economic value of ecosystem services provided by the KSA Red Sea coral reefs, finding that annual per-unit values supporting the traditional fisheries only are on the order of $7000/km2. Finally, we develop some recommendations for refining future applications of these methods to the Red Sea environment and for further research.
    Beschreibung: This research is based on work supported by Award Nos. USA 00002 and KSA 00011 made by the King Abdullah University of Science and Technology (KAUST).
    Schlagwort(e): Ecosystem service ; Supply-side valuation ; Traditional fishery ; Red Sea ; Coral reef ; Bio-economics
    Repository-Name: Woods Hole Open Access Server
    Materialart: Article
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Publikationsdatum: 2022-10-26
    Beschreibung: © The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Hein, C. J., Fallon, A. R., Rosen, P., Hoagland, P., Georgiou, I. Y., FitzGerald, D. M., Morris, M., Baker, S., Marino, G. B., & Fitzsimons, G. Shoreline dynamics along a developed river mouth barrier island: Multi-decadal cycles of erosion and event-driven mitigation. Frontiers in Earth Science, 7(103), (2019), doi:10.3389/feart.2019.00103.
    Beschreibung: Human modifications in response to erosion have altered the natural transport of sediment to and across the coastal zone, thereby potentially exacerbating the impacts of future erosive events. Using a combination of historical shoreline-change mapping, sediment sampling, three-dimensional beach surveys, and hydrodynamic modeling of nearshore and inlet processes, this study explored the feedbacks between periodic coastal erosion patterns and associated mitigation responses, focusing on the open-ocean and inner-inlet beaches of Plum Island and the Merrimack River Inlet, Massachusetts, United States. Installation of river-mouth jetties in the early 20th century stabilized the inlet, allowing residential development in northern Plum Island, but triggering successive, multi-decadal cycles of alternating beach erosion and accretion along the inner-inlet and oceanfront beaches. At a finer spatial scale, the formation and southerly migration of an erosion “hotspot” (a setback of the high-water line by ∼100 m) occurs regularly (every 25–40 years) in response to the refraction of northeast storm waves around the ebb-tidal delta. Growth of the delta progressively shifts the focus of storm wave energy further down-shore, replenishing updrift segments with sand through the detachment, landward migration, and shoreline-welding of swash bars. Monitoring recent hotspot migration (2008–2014) demonstrates erosion (〉30,000 m3 of sand) along a 350-m section of beach in 6 months, followed by recovery, as the hotspot migrated further south. In response to these erosion cycles, local residents and governmental agencies attempted to protect shorefront properties with a variety of soft and hard structures. The latter have provided protection to some homes, but enhanced erosion elsewhere. Although the local community is in broad agreement about the need to plan for long-term coastal changes associated with sea-level rise and increased storminess, real-time responses have involved reactions mainly to short-term (〈5 years) erosion threats. A collective consensus for sustainable management of this area is lacking and the development of a longer-term adaptive perspective needed for proper planning has been elusive. With a deepening understanding of multi-decadal coastal dynamics, including a characterization of the relative contributions of both nature and humans, we can be more optimistic that adaptations beyond mere reactions to shoreline change are achievable.
    Beschreibung: This work was supported financially by the National Science Foundation (NSF) Coastal SEES program (awards OCE 1325430 and OCE 1325366). PH also received partial support through the NSF Coupled Natural-Human Systems program (award AGS 1518503) and the Northeast Regional Sea Grant and Woods Hole Sea Grant Programs (NOAA Cooperative Agreement award NA14OAR4170074).
    Schlagwort(e): Tidal-inlet dynamics ; Beach erosion ; Coastal adaptation ; Developed beach ; Shoreline change
    Repository-Name: Woods Hole Open Access Server
    Materialart: Article
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Publikationsdatum: 2015-09-30
    Beschreibung: Author(s): Danielle S. Bassett, Eli T. Owens, Karen E. Daniels, and Mason A. Porter [Phys. Rev. E 92, 039905] Published Tue Sep 29, 2015
    Schlagwort(e): Errata
    Print ISSN: 1539-3755
    Digitale ISSN: 1550-2376
    Thema: Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Publikationsdatum: 2015-11-21
    Beschreibung: Understanding the mechanisms of chromosomal double-strand break repair (DSBR) provides insight into genome instability, oncogenesis and genome engineering, including disease gene correction. Research into DSBR exploits rare-cutting endonucleases to cleave exogenous reporter constructs integrated into the genome. Multiple reporter constructs have been developed to detect various DSBR pathways. Here, using a single endogenous reporter gene, the X-chromosomal disease gene encoding hypoxanthine phosphoribosyltransferase ( HPRT ), we monitor the relative utilization of three DSBR pathways following cleavage by I-Sce I or CRISPR/Cas9 nucleases. For I-Sce I, our estimated frequencies of accurate or mutagenic non-homologous end-joining and gene correction by homologous recombination are 4.1, 1.5 and 0.16%, respectively. Unexpectedly, I-Sce I and Cas9 induced markedly different DSBR profiles. Also, using an I-Sce I-sensitive HPRT minigene, we show that gene correction is more efficient when using long double-stranded DNA than single- or double-stranded oligonucleotides. Finally, using both endogenous HPRT and exogenous reporters, we validate novel cell cycle phase-specific I-Sce I derivatives for investigating cell cycle variations in DSBR. The results obtained using these novel approaches provide new insights into template design for gene correction and the relationships between multiple DSBR pathways at a single endogenous disease gene.
    Print ISSN: 0964-6906
    Digitale ISSN: 1460-2083
    Thema: Biologie , Medizin
    Publiziert von Oxford University Press
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Publikationsdatum: 2015-11-26
    Beschreibung: Author(s): Mikko Kivelä and Mason A. Porter A diverse variety of processes—including recurrent disease episodes, neuron firing, and communication patterns among humans—can be described using interevent time (IET) distributions. Many such processes are ongoing, although event sequences are only available during a finite observation window. Bec… [Phys. Rev. E 92, 052813] Published Wed Nov 25, 2015
    Schlagwort(e): Networks and Interdisciplinary Physics
    Print ISSN: 1539-3755
    Digitale ISSN: 1550-2376
    Thema: Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Publikationsdatum: 2016-02-07
    Beschreibung: Biochemistry DOI: 10.1021/acs.biochem.5b01071
    Print ISSN: 0006-2960
    Digitale ISSN: 1520-4995
    Thema: Biologie , Chemie und Pharmazie
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Publikationsdatum: 2016-07-09
    Beschreibung: DNA double-strand breaks (DSBs) are toxic lesions, which if improperly repaired can result in cell death or genomic instability. DSB repair is usually facilitated by the classical non-homologous end joining (C-NHEJ), or homologous recombination (HR) pathways. However, a mutagenic alternative NHEJ pathway, microhomology-mediated end joining (MMEJ), can also be deployed. While MMEJ is suppressed by C-NHEJ, the relationship between HR and MMEJ is less clear. Here, we describe a role for HR genes in suppressing MMEJ in human cells. By monitoring DSB mis-repair using a sensitive HPRT assay, we found that depletion of HR proteins, including BRCA2, BRCA1 or RPA, resulted in a distinct mutational signature associated with significant increases in break-induced mutation frequencies, deletion lengths and the annealing of short regions of microhomology (2–6 bp) across the break-site. This signature was dependent on CtIP, MRE11, POLQ and PARP, and thus indicative of MMEJ. In contrast to CtIP or MRE11, depletion of BRCA1 resulted in increased partial resection and MMEJ, thus revealing a functional distinction between these early acting HR factors. Together these findings indicate that HR factors suppress mutagenic MMEJ following DSB resection.
    Print ISSN: 0305-1048
    Digitale ISSN: 1362-4962
    Thema: Biologie
    Publiziert von Oxford University Press
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Publikationsdatum: 2016-07-20
    Beschreibung: Journal of the American Chemical Society DOI: 10.1021/jacs.6b05421
    Print ISSN: 0002-7863
    Digitale ISSN: 1520-5126
    Thema: Chemie und Pharmazie
    Standort Signatur Erwartet Verfügbarkeit
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