Publication Date:
2015-10-31
Description:
Infections and inflammation can lead to cachexia and wasting of skeletal muscle and fat tissue by as yet poorly understood mechanisms. We observed that gut colonization of mice by a strain of Escherichia coli prevents wasting triggered by infections or physical damage to the intestine. During intestinal infection with the pathogen Salmonella Typhimurium or pneumonic infection with Burkholderia thailandensis, the presence of this E. coli did not alter changes in host metabolism, caloric uptake, or inflammation but instead sustained signaling of the insulin-like growth factor 1/phosphatidylinositol 3-kinase/AKT pathway in skeletal muscle, which is required for prevention of muscle wasting. This effect was dependent on engagement of the NLRC4 inflammasome. Therefore, this commensal promotes tolerance to diverse diseases.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732872/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732872/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schieber, Alexandria M Palaferri -- Lee, Yujung Michelle -- Chang, Max W -- Leblanc, Mathias -- Collins, Brett -- Downes, Michael -- Evans, Ronald M -- Ayres, Janelle S -- CA014195/CA/NCI NIH HHS/ -- DK0577978/DK/NIDDK NIH HHS/ -- P30 CA014195/CA/NCI NIH HHS/ -- R01 AI114929/AI/NIAID NIH HHS/ -- R01AI114929/AI/NIAID NIH HHS/ -- R37 DK057978/DK/NIDDK NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2015 Oct 30;350(6260):558-63. doi: 10.1126/science.aac6468.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Nomis Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. ; Integrative Genomics and Bioinformatics Core, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. ; Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. ; Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. ; Nomis Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. jayres@salk.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26516283" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Apoptosis Regulatory Proteins/metabolism
;
Biosynthetic Pathways
;
Burkholderia
;
Burkholderia Infections/complications
;
Calcium-Binding Proteins/metabolism
;
Escherichia coli/*immunology
;
Inflammasomes/*immunology
;
Insulin-Like Growth Factor I/*metabolism
;
Intestines/*microbiology
;
Mice
;
Mice, Inbred C57BL
;
*Microbiota
;
Muscle, Skeletal/*metabolism
;
Phosphatidylinositol 3-Kinase/metabolism
;
Proto-Oncogene Proteins c-akt/metabolism
;
Salmonella Infections/complications
;
Salmonella typhimurium
;
Wasting Syndrome/etiology/*immunology/*microbiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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