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  • 2015-2019  (186)
  • 1985-1989  (72)
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Year
  • 1
    Monograph available for loan
    Monograph available for loan
    Control Surveys in civil engineering (1987)
    New York : Nichols
    Details Availability
    Call number: M 12.0218
    Type of Medium: Monograph available for loan
    Pages: xiii, 381 S.
    ISBN: 089397272X
    Classification:
    Geodetic Theory and Modeling
    Location: Upper compact magazine
    Branch Library: GFZ Library
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  • 2
    Unknown
    Inversion Tectonics (1989)
    Oxford, London, Edinburgh, Boston, Melbourne : Blackwell Scientific Publications
    Details
    Keywords: Aufschiebung ; Überschiebung ; Tektonik ; Erdkruste ; Inversions (Geology)
    Description / Table of Contents: M. A. Cooper and G. D. Williams: Introduction / Geological Society, London, Special Publications, 44:vii, doi:10.1144/GSL.SP.1989.044.01.01 --- Modelling and Theoretical Concepts --- G. D. Williams, C. M. Powell, and M. A. Cooper: Geometry and kinematics of inversion tectonics / Geological Society, London, Special Publications, 44:3-15, doi:10.1144/GSL.SP.1989.044.01.02 --- A. B. Hayward and R. H. Graham: Some geometrical characteristics of inversion / Geological Society, London, Special Publications, 44:17-39, doi:10.1144/GSL.SP.1989.044.01.03 --- K. R. McClay: Analogue models of inversion tectonics / Geological Society, London, Special Publications, 44:41-59, doi:10.1144/GSL.SP.1989.044.01.04 --- Inversion in the Alps and Alpine Foreland --- P. A. Ziegler: Geodynamic model for Alpine intra-plate compressional deformation in Western and Central Europe / Geological Society, London, Special Publications, 44:63-85, doi:10.1144/GSL.SP.1989.044.01.05 --- P. C. de Graciansky, G. Dardeau, M. Lemoine, and P. Tricart: The inverted margin of the French Alps and foreland basin inversion / Geological Society, London, Special Publications, 44:87-104, doi:10.1144/GSL.SP.1989.044.01.06 --- R. W. H. Butler: The influence of pre-existing basin structure on thrust system evolution in the Western Alps / Geological Society, London, Special Publications, 44:105-122, doi:10.1144/GSL.SP.1989.044.01.07 --- I. R. Simpson, M. Gravestock, D. Ham, H. Leach, and S. D. Thompson: Notes and cross-sections illustrating inversion tectonics in the Wessex Basin / Geological Society, London, Special Publications, 44:123-129, doi:10.1144/GSL.SP.1989.044.01.08 --- D. G. Roberts: Basin inversion in and around the British Isles / Geological Society, London, Special Publications, 44:131-150, doi:10.1144/GSL.SP.1989.044.01.09 --- Inversion on the European Continental Shelf --- J. A. Cartwright: The kinematics of inversion in the Danish Central Graben / Geological Society, London, Special Publications, 44:153-175, doi:10.1144/GSL.SP.1989.044.01.10 --- T. J. Chapman: The Permian to Cretaceous structural evolution of the Western Approaches Basin (Melville sub-basin), UK / Geological Society, London, Special Publications, 44:177-200, doi:10.1144/GSL.SP.1989.044.01.11 --- M. E. Badley, J. D. Price, and L. C. Backshall: Inversion, reactivated faults and related structures: seismic examples from the southern North Sea / Geological Society, London, Special Publications, 44:201-219, doi:10.1144/GSL.SP.1989.044.01.12 --- Inversion in Other Geological Environments --- C. M. Powell and G. D. Williams: The Lewis Thrust/Rocky Mountain trench fault system in Northwest Montana, USA: an example of negative inversion tectonics? / Geological Society, London, Special Publications, 44:223-234, doi:10.1144/GSL.SP.1989.044.01.13 --- K. R. McClay, M. W. Insley, and R. Anderton: Inversion of the Kechika Trough, Northeastern British Columbia, Canada / Geological Society, London, Special Publications, 44:235-257, doi:10.1144/GSL.SP.1989.044.01.14 --- C. K. Morley: Basin inversion in the Osen-Røa thrust sheet, Southern Norway / Geological Society, London, Special Publications, 44:259-273, doi:10.1144/GSL.SP.1989.044.01.15 --- M. P. Coward, M. A. Enfield, and M. W. Fischer: Devonian basins of Northern Scotland: extension and inversion related to Late Caledonian — Variscan tectonics / Geological Society, London, Special Publications, 44:275-308, doi:10.1144/GSL.SP.1989.044.01.16 --- M. C. Daly, J. Chorowicz, and J. D. Fairhead: Rift basin evolution in Africa: the influence of reactivated steep basement shear zones / Geological Society, London, Special Publications, 44:309-334, doi:10.1144/GSL.SP.1989.044.01.17 --- M. A. Cooper, G. D. Williams, P. C. de Graciansky, R. W. Murphy, T. Needham, D. de Paor, R. Stoneley, S. P. Todd, J. P. Turner, and P. A. Ziegler: Inversion tectonics — a discussion / Geological Society, London, Special Publications, 44:335-347, doi:10.1144/GSL.SP.1989.044.01.18 --- Abstracts --- I. W. D. Dalziel: Inversion of circum-Pacific marginal basins / Geological Society, London, Special Publications, 44:351, doi:10.1144/GSL.SP.1989.044.01.19 --- J. F. Dewey: Kinematics and dynamics of basin inversion / Geological Society, London, Special Publications, 44:352, doi:10.1144/GSL.SP.1989.044.01.20 --- A. Gibbs and A. Beach: Extensional tectonics in a convergent intra-plate setting: linked inversions on oblique and frontal ramps / Geological Society, London, Special Publications, 44:353, doi:10.1144/GSL.SP.1989.044.01.21 --- R. Gillcrist, M. P. Coward, B. Trudgill, A. Pecher, and J. L. Mugnier: Structural inversion in the external French Alps / Geological Society, London, Special Publications, 44:354, doi:10.1144/GSL.SP.1989.044.01.22 --- N. J. Kusznir and G. D. Williams: Geometric, thermal and isostatic constraints on basin inversion / Geological Society, London, Special Publications, 44:355, doi:10.1144/GSL.SP.1989.044.01.23 --- B. van Hoorn: Structural evolution, timing and tectonic style of the Sole Pit inversion / Geological Society, London, Special Publications, 44:356, doi:10.1144/GSL.SP.1989.044.01.24
    Pages: Online-Ressource (VII, 375 Seiten) , Illustrationen, Diagramme, Karten
    ISBN: 0632025026
    URL: http://sp.lyellcollection.org/content/44/1
    Language: English
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  • 3
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    Set7 mediated interactions regulate transcriptional networks in embryonic stem cells (2016)
    Oxford University Press
    Details
    Publication Date: 2016-11-01
    Description: Histone methylation by lysine methyltransferase enzymes regulate the expression of genes implicated in lineage specificity and cellular differentiation. While it is known that Set7 catalyzes mono-methylation of histone and non-histone proteins, the functional importance of this enzyme in stem cell differentiation remains poorly understood. We show Set7 expression is increased during mouse embryonic stem cell (mESC) differentiation and is regulated by the pluripotency factors, Oct4 and Sox2. Transcriptional network analyses reveal smooth muscle (SM) associated genes are subject to Set7-mediated regulation. Furthermore, pharmacological inhibition of Set7 activity confirms this regulation. We observe Set7-mediated modification of serum response factor (SRF) and mono-methylation of histone H4 lysine 4 (H3K4me1) regulate gene expression. We conclude the broad substrate specificity of Set7 serves to control key transcriptional networks in embryonic stem cells.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 4
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    Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequences (2016)
    Oxford University Press
    Details
    Publication Date: 2016-07-09
    Description: Gross chromosomal rearrangements (including translocations, deletions, insertions and duplications) are a hallmark of cancer genomes and often create oncogenic fusion genes. An obligate step in the generation of such gross rearrangements is the formation of DNA double-strand breaks (DSBs). Since the genomic distribution of rearrangement breakpoints is non-random, intrinsic cellular factors may predispose certain genomic regions to breakage. Notably, certain DNA sequences with the potential to fold into secondary structures [potential non-B DNA structures (PONDS); e.g. triplexes, quadruplexes, hairpin/cruciforms, Z-DNA and single-stranded looped-out structures with implications in DNA replication and transcription] can stimulate the formation of DNA DSBs. Here, we tested the postulate that these DNA sequences might be found at, or in close proximity to, rearrangement breakpoints. By analyzing the distribution of PONDS-forming sequences within ±500 bases of 19 947 translocation and 46 365 sequence-characterized deletion breakpoints in cancer genomes, we find significant association between PONDS-forming repeats and cancer breakpoints. Specifically, (AT) n , (GAA) n and (GAAA) n constitute the most frequent repeats at translocation breakpoints, whereas A-tracts occur preferentially at deletion breakpoints. Translocation breakpoints near PONDS-forming repeats also recur in different individuals and patient tumor samples. Hence, PONDS-forming sequences represent an intrinsic risk factor for genomic rearrangements in cancer genomes.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 5
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    An integrative approach to predicting the functional effects of non-coding and coding sequence variation (2015)
    Oxford University Press
    Details
    Publication Date: 2015-05-12
    Description: Motivation: Technological advances have enabled the identification of an increasingly large spectrum of single nucleotide variants within the human genome, many of which may be associated with monogenic disease or complex traits. Here, we propose an integrative approach, named FATHMM-MKL, to predict the functional consequences of both coding and non-coding sequence variants. Our method utilizes various genomic annotations, which have recently become available, and learns to weight the significance of each component annotation source. Results: We show that our method outperforms current state-of-the-art algorithms, CADD and GWAVA, when predicting the functional consequences of non-coding variants. In addition, FATHMM-MKL is comparable to the best of these algorithms when predicting the impact of coding variants. The method includes a confidence measure to rank order predictions. Availability and implementation: The FATHMM-MKL webserver is available at: http://fathmm.biocompute.org.uk Contact: H.Shihab@bristol.ac.uk or Mark.Rogers@bristol.ac.uk or C.Campbell@bristol.ac.uk Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Published by Oxford University Press
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  • 6
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    DDIG-in: detecting disease-causing genetic variations due to frameshifting indels and nonsense mutations employing sequence and structural properties at nucleotide and protein levels (2015)
    Oxford University Press
    Details
    Publication Date: 2015-05-12
    Description: Motivation : Frameshifting (FS) indels and nonsense (NS) variants disrupt the protein-coding sequence downstream of the mutation site by changing the reading frame or introducing a premature termination codon, respectively. Despite such drastic changes to the protein sequence, FS indels and NS variants have been discovered in healthy individuals. How to discriminate disease-causing from neutral FS indels and NS variants is an understudied problem. Results: We have built a machine learning method called DDIG-in (FS) based on real human genetic variations from the Human Gene Mutation Database (inherited disease-causing) and the 1000 Genomes Project (GP) (putatively neutral). The method incorporates both sequence and predicted structural features and yields a robust performance by 10-fold cross-validation and independent tests on both FS indels and NS variants. We showed that human-derived NS variants and FS indels derived from animal orthologs can be effectively employed for independent testing of our method trained on human-derived FS indels. DDIG-in (FS) achieves a Matthews correlation coefficient (MCC) of 0.59, a sensitivity of 86%, and a specificity of 72% for FS indels. Application of DDIG-in (FS) to NS variants yields essentially the same performance (MCC of 0.43) as a method that was specifically trained for NS variants. DDIG-in (FS) was shown to make a significant improvement over existing techniques. Availability and implementation : The DDIG-in web-server for predicting NS variants, FS indels, and non-frameshifting (NFS) indels is available at http://sparks-lab.org/ddig . Contact : yaoqi.zhou@griffith.edu.au Supplementary information : Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Published by Oxford University Press
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  • 7
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    Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension (2016)
    Springer Nature
    Details
    Publication Date: 2016-04-02
    Description: Article The stability of epithelial adherens junctions depends on tension generated by actomyosin contractility. Here Lee et al . describe a novel role for the axon guidance receptor Neogenin in maintaining junctional stability by recruiting actin nucleation machinery to adherens junctions. Nature Communications doi: 10.1038/ncomms11082 Authors: Natalie K. Lee, Ka Wai Fok, Amanda White, Nicole H. Wilson, Conor J. O’Leary, Hayley L. Cox, Magdalene Michael, Alpha S. Yap, Helen M. Cooper
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 8
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    GEneSTATION 1.0: a synthetic resource of diverse evolutionary and functional genomic data for studying the evolution of pregnancy-associated tissues and phenotypes (2016)
    Oxford University Press
    Details
    Publication Date: 2016-01-07
    Description: Mammalian gestation and pregnancy are fast evolving processes that involve the interaction of the fetal, maternal and paternal genomes. Version 1.0 of the GEneSTATION database ( http://genestation.org ) integrates diverse types of omics data across mammals to advance understanding of the genetic basis of gestation and pregnancy-associated phenotypes and to accelerate the translation of discoveries from model organisms to humans. GEneSTATION is built using tools from the Generic Model Organism Database project, including the biology-aware database CHADO, new tools for rapid data integration, and algorithms that streamline synthesis and user access. GEneSTATION contains curated life history information on pregnancy and reproduction from 23 high-quality mammalian genomes. For every human gene, GEneSTATION contains diverse evolutionary (e.g. gene age, population genetic and molecular evolutionary statistics), organismal (e.g. tissue-specific gene and protein expression, differential gene expression, disease phenotype), and molecular data types (e.g. Gene Ontology Annotation, protein interactions), as well as links to many general (e.g. Entrez, PubMed) and pregnancy disease-specific (e.g. PTBgene, dbPTB) databases. By facilitating the synthesis of diverse functional and evolutionary data in pregnancy-associated tissues and phenotypes and enabling their quick, intuitive, accurate and customized meta-analysis, GEneSTATION provides a novel platform for comprehensive investigation of the function and evolution of mammalian pregnancy.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 9
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    Corrigendum: Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure (2015)
    Springer Nature
    Details
    Publication Date: 2015-12-15
    Description: Corrigendum: Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure Scientific Reports, Published online: 14 December 2015; doi:10.1038/srep17119
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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  • 10
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    Branched hybridization chain reaction—using highly dimensional DNA nanostructures for label-free, reagent-less, multiplexed molecular diagnostics (2019)
    Details
    Publication Date: 2019
    Print ISSN: 2096-1030
    Electronic ISSN: 2055-7434
    Topics: Electrical Engineering, Measurement and Control Technology , Energy, Environment Protection, Nuclear Power Engineering , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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