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  • FLUID MECHANICS AND HEAT TRANSFER  (3)
  • Aerodynamics; Fluid Mechanics and Thermodynamics  (2)
  • drug resistance  (1)
  • 2015-2019  (2)
  • 1985-1989  (4)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cell biology and toxicology 2 (1986), S. 357-368 
    ISSN: 1573-6822
    Keywords: chemosensitivity ; deceleratory growth ; drug resistance ; high-density chemoresistance ; in vitro solid tumor model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Shortly after reaching confluency, canine MDCK cells enter a prolonged state of basal growth with doubling times of 200–300 hours. These values are similar to those commonly exhibited by in vivo solid tumors at clinically relevant sizes. By comparison with rapidly growing sparse density cultures, the postconfluent monolayers displayed a pronounced resistance to deazauridine, deoxyspergualin, and 5-fluorouridine. Drug concentrations required for unit levels of effect increased from several fold to several orders of magnitude as cells entered high density basal growth. This high density chemoresistance was observed for both growth inhibition and cytotoxicity, but was much more pronounced with the former. Dose-response curves were biphasic, suggesting that growth inhibition and cytotoxicity may be mediated by different mechanisms of drug action. The pronounced chemoresistance of postconfluent MDCK monolayers is similar to that encountered with many clinical solid neoplasms. It suggests that postconfluency monolayers, like multicellular spheroids and cellular multilayers, may provide better in vitro models of solid tumor chemosensitivity than subconfluent monolayer and suspension cultures.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2011-08-19
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: AIAA Journal (ISSN 0001-1452); 25; 527-534
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  • 3
    Publication Date: 2011-08-19
    Description: An implicit upwind scheme for the compressible Navier-Stokes equations is described and applied to the internal flow in a dual-throat nozzle. The method is second-order accurate spatially and naturally dissipative. A spatially-split approximate factorization method is used to obtain efficient steady-state solutions on the NASA Langley VPS-32 (CYBER 205) supercomputer.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
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  • 4
    Publication Date: 2017-10-02
    Description: A comparative study was made using 4 different computer codes for solving the compressible Navier-Stokes equations. Three different test problems were used, each of which has features typical of high speed internal flow problems of practical importance in the design and analysis of propulsion systems for advanced hypersonic vehicles. These problems are the supersonic flow between two walls, one of which contains a 10 deg compression ramp, the flow through a hypersonic inlet, and the flow in a 3-D corner formed by the intersection of two symmetric wedges. Three of the computer codes use similar recently developed implicit upwind differencing technology, while the fourth uses a well established explicit method. The computed results were compared with experimental data where available.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: AGARD, Validation of Computational Fluid Dynamics. Volume 1: Symposium Papers and Round Table Discussion; 15 p
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  • 5
    Publication Date: 2019-07-13
    Description: A detailed grid convergence study has been conducted to establish accurate reference solutions corresponding to the one-equation linear eddy-viscosity Spalart-Allmaras turbulence model for two dimensional turbulent flows around the NACA 0012 airfoil and a flat plate. The study involved three widely used codes, CFL3D (NASA), FUN3D (NASA), and TAU (DLR), and families of uniformly refined structured grids that differ in the grid density patterns. Solutions computed by different codes on different grid families appear to converge to the same continuous limit, but exhibit different convergence characteristics. The grid resolution in the vicinity of geometric singularities, such as a sharp trailing edge, is found to be the major factor affecting accuracy and convergence of discrete solutions, more prominent than differences in discretization schemes and/or grid elements. The results reported for these relatively simple turbulent flows demonstrate that CFL3D, FUN3D, and TAU solutions are very accurate on the finest grids used in the study, but even those grids are not sufficient to conclusively establish an asymptotic convergence order.
    Keywords: Aerodynamics; Fluid Mechanics and Thermodynamics
    Type: NF1676L-18876 , AIAA Science and Technology Forum and Exposition (AIAA SciTech 2015); Jan 05, 2015 - Jan 09, 2015; Kissimmee, FL; United States
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  • 6
    Publication Date: 2019-07-13
    Description: A grid convergence study is performed to establish benchmark solutions for turbulent flows in three dimensions (3D) in support of turbulence-model verification campaign at the Turbulence Modeling Resource (TMR) website. The three benchmark cases are subsonic flows around a 3D bump and a hemisphere-cylinder configuration and a supersonic internal flow through a square duct. Reference solutions are computed for Reynolds Averaged Navier Stokes equations with the Spalart-Allmaras turbulence model using a linear eddy-viscosity model for the external flows and a nonlinear eddy-viscosity model based on a quadratic constitutive relation for the internal flow. The study involves three widely-used practical computational fluid dynamics codes developed and supported at NASA Langley Research Center: FUN3D, USM3D, and CFL3D. Reference steady-state solutions computed with these three codes on families of consistently refined grids are presented. Grid-to-grid and code-to-code variations are described in detail.
    Keywords: Aerodynamics; Fluid Mechanics and Thermodynamics
    Type: NF1676L-21502 , 2016 AIAA SciTech Conference; Jan 04, 2016 - Jan 08, 2016; San Diego, CA; United States
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