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  • 1
    Publication Date: 2015-06-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cutter, Susan L -- Ismail-Zadeh, Alik -- Alcantara-Ayala, Irasema -- Altan, Orhan -- Baker, Daniel N -- Briceno, Salvano -- Gupta, Harsh -- Holloway, Ailsa -- Johnston, David -- McBean, Gordon A -- Ogawa, Yujiro -- Paton, Douglas -- Porio, Emma -- Silbereisen, Rainer K -- Takeuchi, Kuniyoshi -- Valsecchi, Giovanni B -- Vogel, Coleen -- Wu, Guoxiong -- England -- Nature. 2015 Jun 18;522(7556):277-9. doi: 10.1038/522277a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Hazards and Vulnerability Research Institute at the University of South Carolina, Columbia, USA. ; Karlsruhe Institute of Technology, Karlsruhe, Germany, and at the Institute of Earthquake Prediction, Russian Academy of Sciences, Moscow, Russia. ; Institute of Geography, National Autonomous University of Mexico, Mexico City, Mexico. ; Istanbul Technical University, Istanbul, Turkey. ; Laboratory for Atmospheric and Space Physics, University of Colorado at Boulder, Colorado, USA. ; United Nations Office for Disaster Risk Reduction, Divonne-les-Bains, France. ; National Geophysical Research Institute, Hyderabad, India, and a former member of the National Disaster Management Authority, Government of India, Delhi, India. ; Research Alliance for Disaster and Risk Reduction, Stellenbosch University, Stellenbosch, South Africa. ; Joint Centre for Disaster Research at Massey University and Senior Scientist at GNS Science, Wellington, New Zealand. ; Centre for Environment and Sustainability, and director of policy studies at the Institute for Catastrophic Loss Reduction, University of Western Ontario, London, Canada. ; Institute of Geosciences at the University of Tsukuba, Tsukuba, Japan. ; School of Psychological and Clinical Sciences, Charles Darwin University, Australia. ; Department of Sociology and Anthropology at Ateneo de Manila University, Quezon City, the Philippines. ; Center for Applied Developmental Science, University of Jena, Jena, Germany. ; Civil and Environmental Engineering Department, University of Yamanashi, Kofu, Japan, and founding director of the International Centre for Water Hazard Risk Management, Tsukuba, Japan. ; National Institute for Astrophysics, Rome, Italy, and at the National Research Council, Sesto Fiorentino, Italy. ; University of the Witwatersrand, Johannesburg, South Africa. ; Institute of Atmospheric Physics of the Chinese Academy of Sciences, Beijing, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26085255" target="_blank"〉PubMed〈/a〉
    Keywords: Building Codes ; Disaster Planning/economics/*methods ; Disasters/economics/*prevention & control/statistics & numerical data ; Earthquakes/mortality ; Humans ; International Cooperation/legislation & jurisprudence ; Nepal/epidemiology ; *Policy Making ; Risk Management/economics/*methods ; Risk Reduction Behavior
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 1991-06-21
    Description: The sequence of a Pst I restriction fragment was determined that demonstrate instability in fragile X syndrome pedigrees. The region of instability was localized to a trinucleotide repeat p(CCG)n. The sequence flanking this repeat were identical in normal and affected individuals. The breakpoints in two somatic cell hybrids constructed to break at the fragile site also mapped to this repeat sequence. The repeat exhibits instability both when cloned in a nonhomologous host and after amplification by the polymerase chain reaction. These results suggest variation in the trinucleotide repeat copy number as the molecular basis for the instability and possibly the fragile site. This would account for the observed properties of this region in vivo and in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kremer, E J -- Pritchard, M -- Lynch, M -- Yu, S -- Holman, K -- Baker, E -- Warren, S T -- Schlessinger, D -- Sutherland, G R -- Richards, R I -- New York, N.Y. -- Science. 1991 Jun 21;252(5013):1711-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cytogenetics and Molecular Genetics, Adelaide Children's Hospital, South Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1675488" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Blotting, Southern ; Chromosome Mapping ; Fragile X Syndrome/*genetics ; Humans ; Molecular Sequence Data ; Pedigree ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Repetitive Sequences, Nucleic Acid ; Restriction Mapping ; X Chromosome/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 1992-11-27
    Description: The cystic fibrosis gene product (CFTR) is a complex protein that functions as an adenosine 3,5-monophosphate (cAMP)-stimulated ion channel and possibly as a regulator of intracellular processes. In order to determine whether the CFTR molecule contains a functional aqueous pathway, anion, water, and urea transport were measured in Xenopus oocytes expressing CFTR. Cyclic AMP agonists induced a Cl- conductance of 94 microsiemens and an increase in water permeability of 4 x 10(-4) centimeter per second that was inhibited by a Cl- channel blocker and was dependent on anion composition. CFTR has a calculated single channel water conductance of 9 x 10(-13) cubic centimeter per second, suggesting a pore-like aqueous pathway. Oocytes expressing CFTR also showed cAMP-stimulated transport of urea but not the larger solute sucrose. Thus CFTR contains a cAMP-stimulated aqueous pore that can transport anions, water, and small solutes. The results also provide functional evidence for water movement through an ion channel.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hasegawa, H -- Skach, W -- Baker, O -- Calayag, M C -- Lingappa, V -- Verkman, A S -- DK35124/DK/NIDDK NIH HHS/ -- DK43840/DK/NIDDK NIH HHS/ -- HL42368/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1992 Nov 27;258(5087):1477-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of California, San Francisco 94143-0532.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1279809" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Transport/physiology ; Chlorides/metabolism ; Cyclic AMP/physiology ; Cystic Fibrosis Transmembrane Conductance Regulator ; Female ; Humans ; In Vitro Techniques ; Ion Channels/*physiology ; Membrane Proteins/*physiology ; Molecular Sequence Data ; Oocytes ; Urea/metabolism ; Water/metabolism ; Xenopus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 1990-12-07
    Description: In the development of multicellular organisms a diversity of cell types differentiate at specific positions. Spacing patterns, in which an array of two or more cell types forms from a uniform field of cells, are a common feature of development. Identical precursor cells may adopt different fates because of competition and inhibition between them. Such a pattern in the developing Drosophila eye is the evenly spaced array of R8 cells, around which other cell types are subsequently recruited. Genetic studies suggest that the scabrous mutation disrupts a signal produced by R8 cells that inhibits other cells from also becoming R8 cells. The scabrous locus was cloned, and it appears to encode a secreted protein partly related to the beta and gamma chains of fibrinogen. It is proposed that the sca locus encodes a lateral inhibitor of R8 differentiation. The roles of the Drosophila EGF-receptor homologue (DER) and Notch genes in this process were also investigated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baker, N E -- Mlodzik, M -- Rubin, G M -- New York, N.Y. -- Science. 1990 Dec 7;250(4986):1370-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, University of California, Berkeley 94720.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2175046" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Amino Acid Sequence ; Animals ; Cell Differentiation ; DNA Transposable Elements ; Drosophila/anatomy & histology/*genetics/growth & development ; *Drosophila Proteins ; Eye/anatomy & histology/growth & development ; Fibrinogen/*genetics ; *Glycoproteins ; Humans ; Molecular Sequence Data ; Mosaicism ; *Mutation ; Phenotype ; Proteins/*genetics ; Receptor, Epidermal Growth Factor/genetics ; Sequence Homology, Nucleic Acid
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 1990-08-24
    Description: Mutations of the p53 gene occur commonly in colorectal carcinomas and the wild-type p53 allele is often concomitantly deleted. These findings suggest that the wild-type gene may act as a suppressor of colorectal carcinoma cell growth. To test this hypothesis, wild-type or mutant human p53 genes were transfected into human colorectal carcinoma cell lines. Cells transfected with the wild-type gene formed colonies five- to tenfold less efficiently than those transfected with a mutant p53 gene. In those colonies that did form after wild-type gene transfection, the p53 sequences were found to be deleted or rearranged, or both, and no exogenous p53 messenger RNA expression was observed. In contrast, transfection with the wild-type gene had no apparent effect on the growth of epithelial cells derived from a benign colorectal tumor that had only wild-type p53 alleles. Immunocytochemical techniques demonstrated that carcinoma cells expressing the wild-type gene did not progress through the cell cycle, as evidenced by their failure to incorporate thymidine into DNA. These studies show that the wild-type gene can specifically suppress the growth of human colorectal carcinoma cells in vitro and that an in vivo-derived mutation resulting in a single conservative amino acid substitution in the p53 gene product abrogates this suppressive ability.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baker, S J -- Markowitz, S -- Fearon, E R -- Willson, J K -- Vogelstein, B -- CA 43703/CA/NCI NIH HHS/ -- GM 07184/GM/NIGMS NIH HHS/ -- GM 07309/GM/NIGMS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1990 Aug 24;249(4971):912-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Oncology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2144057" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division ; Cell Line ; Colonic Neoplasms ; DNA Replication ; Humans ; Nuclear Proteins/genetics ; Oncogene Proteins/*genetics/physiology ; Phosphoproteins/*genetics/physiology ; Plasmids ; RNA, Messenger/genetics ; Rectal Neoplasms ; *Transfection ; Tumor Cells, Cultured/*cytology ; Tumor Suppressor Protein p53
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 1991-05-24
    Description: DNA sequences have been located at the fragile X site by in situ hybridization and by the mapping of breakpoints in two somatic cell hybrids that were constructed to break at the fragile site. These hybrids were found to have breakpoints in a common 5-kilobase Eco RI restriction fragment. When this fragment was used as a probe on the chromosomal DNA of normal and fragile X genotype individuals, alterations in the mobility of the sequences detected by the probe were found only in fragile X genotype DNA. These sequences were of an increased size in all fragile X individuals and varied within families, indicating that the region was unstable. This probe provides a means with which to analyze fragile X pedigrees and is a diagnostic reagent for the fragile X genotype.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yu, S -- Pritchard, M -- Kremer, E -- Lynch, M -- Nancarrow, J -- Baker, E -- Holman, K -- Mulley, J C -- Warren, S T -- Schlessinger, D -- New York, N.Y. -- Science. 1991 May 24;252(5009):1179-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cytogenetics and Molecular Genetics, Adelaide Children's Hospital, South Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2031189" target="_blank"〉PubMed〈/a〉
    Keywords: Chromosome Mapping ; DNA/*genetics ; Female ; Fragile X Syndrome/*genetics ; Genotype ; Humans ; Hybrid Cells/cytology ; Male ; Nucleic Acid Hybridization ; Reference Values ; Restriction Mapping ; X Chromosome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2015-01-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fernandez-Capetillo, Oscar -- Yan, Nieng -- Dionne, Jen -- Bassett, Danielle -- Sebastian, Suchitra -- Hendon, Christine -- Schlichting, Hilke -- Baker, Monya -- England -- Nature. 2015 Jan 1;517(7532):111-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25568916" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Aging/genetics ; Astronomy ; Biomedical Engineering/trends ; Cryoelectron Microscopy ; DNA Damage ; Diagnostic Imaging ; Humans ; Interdisciplinary Communication ; Interdisciplinary Studies ; Nanostructures/radiation effects ; Neoplasms/genetics ; Neurosciences/trends ; Planets ; Research/*trends ; *Research Personnel/psychology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 8
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    Nature Publishing Group (NPG)
    Publication Date: 2015-11-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baker, Monya -- England -- Nature. 2015 Nov 26;527(7579):545-51. doi: 10.1038/527545a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Nature in San Francisco, California.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26607547" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies/*immunology ; Antibody Specificity/*immunology ; Cross Reactions/immunology ; Humans ; Immunoassay/*methods/*standards ; Indicators and Reagents/standards ; International Cooperation ; Mice ; National Institutes of Health (U.S.) ; Neuroanatomy/methods/standards ; Periodicals as Topic ; Reproducibility of Results ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2015-05-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baker, Monya -- England -- Nature. 2015 May 21;521(7552):274-6. doi: 10.1038/521274a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25993940" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies/chemistry/economics/genetics/*immunology ; Antibody Specificity/*immunology ; *Artifacts ; Cross Reactions/immunology ; Humans ; Indicators and Reagents/economics/standards ; Membrane Proteins/immunology ; Quality Control ; Reagent Kits, Diagnostic/standards ; Reproducibility of Results
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 10
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    Nature Publishing Group (NPG)
    Publication Date: 2015-07-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baker, Monya -- England -- Nature. 2015 Jul 16;523(7560):276-8. doi: 10.1038/523276a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26178949" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Child ; Child, Preschool ; Curriculum/trends ; Humans ; Internationality ; Learning ; Physics/education ; Research Personnel/education ; Science/*education ; Students/*psychology ; Teaching/*methods/trends
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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