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  • Springer  (22)
  • 2015-2019  (1)
  • 1990-1994  (14)
  • 1965-1969  (7)
  • 1
    Electronic Resource
    Electronic Resource
    Full-pose calibration of a robot manipulator using a coordinate-measuring machine (1993)
    Springer
    The international journal of advanced manufacturing technology 8 (1993), S. 34-41 
    Details
    ISSN: 1433-3015
    Keywords: Robot calibration ; Coordinate measurement ; Parameter identification ; Simulation study ; Accuracy enhancement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The work reported in this article addresses the kinematic calibration of a robot manipulator using a coordinate measuring machine (CMM) which is able to obtain the full pose of the end-effector. A kinematic model is developed for the manipulator, its relationship to the world coordinate frame and the tool. The derivation of the tool pose from experimental measurements is discussed, as is the identification methodology. A complete simulation of the experiment is performed, allowing the observation strategy to be defined. The experimental work is described together with the parameter identification and accuracy verification. The principal conclusion is that the method is able to calibrate the robot successfully, with a resulting accuracy approaching that of its repeatability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01756635
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  • 2
    Electronic Resource
    Electronic Resource
    Disposition of epirubicin and metabolites with repeated courses to cancer patients (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 481-487 
    Details
    ISSN: 1432-1041
    Keywords: Epirubicin ; pharmacokinetics ; plasma concentrations ; cancer patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Thirteen cancer patients were studied following a total of 41 courses of epirubicin (EPI) (38–50 mg·m−2, mean 49.2 mg·m−2, administered by a 60 min infusion), together with other cancer chemotherapeutic agents. The aim was to consider the disposition of EPI and metabolites following subsequent courses as it has been reported that doxorubicin (the 4′-epimer parent of EPI) clearance is increased following the first administration. We have observed that EPI-glucuronide accounted for a mean 78.0%, epirubicinol 0.2% and epirubicinol-glucuronide 19.3% and that parent EPI accounted for only 2.4% of the EPI-compounds measured (mean of all patients and courses) for the 3 h period immediately following the infusion. These data confirm the rapid metabolism of EPI and the dominance of the glucuronidation metabolite pathway (which is not available to doxorubicin) and are compared with the metabolite profile observed in other reports. Large inter- and intra-individual variability in area under the plasma concentration/time curve were observed with no clear evidence of any consistent directional trend for such fluctuations, suggesting that factors contributing to EPI disposition are multivariate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315227
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  • 3
    Electronic Resource
    Electronic Resource
    Interference from digoxin-like immunoreactive substance(s) in commercial digoxin kit assay methods (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 359-363 
    Details
    ISSN: 1432-1041
    Keywords: digoxin ; immunoassay ; analytical interference ; therapeutic drug monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have examined the current state of interference by digoxin-like immunoreactive substance(s) (DLIS) in 10 commercially available digoxin assay methods, ie 5 radioimmunoassays (RIA) and 5 non-radioactive immunoassays. Fifty-five specimens of maternal venous blood (30 from third trimester pregnancy and 25 at delivery) and 32 cord samples from their offspring were tested (none of the subjects being medicated with digoxin). The results demonstrated a wide range of DLIS interference with values up to 1.1 μg·l−1 being obtained in the cord blood specimens. Of the methods tested the “Coat-a Count” RIA (Diagnostic Products Corporation) and the EMIT column method (Syva) run on the Cobas MIRA (Roche) consistently showed the least interference with respect to all 3 sources of specimens. The Delfia Method (LKB/Wallac) consistently showed the greatest crossreactivity with DLIS. The present study thus demonstrates that DLIS interference persists in several commercial digoxin methods and suggests that the use of data obtained from such methods may compromise patient management.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315410
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  • 4
    Electronic Resource
    Electronic Resource
    Digoxin-like immunoreactive substance levels in cord blood obtained from twins (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 199-200 
    Details
    ISSN: 1432-1041
    Keywords: Digoxin-like immunoreative substance (DLIS) ; cord blood ; twins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00280079
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  • 5
    Electronic Resource
    Electronic Resource
    Some body fluid characteristics of the Antarctic fish, Trematomus bernacchii (1968)
    Springer
    Marine biology 1 (1968), S. 269-276 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract An examination of some characteristics of the blood plasma and urine of Trematomus bernacchii, an Antarctic fish, shows that at least in certain seasons the freezing points of these fluids are adjusted in response to environmental temperature. During October and November, freezing point of the urine was found to be about 0.7°C higher than that of the water. Adjustment of freezing point is seen to be intimately related to chloride concentration. At high temperatures magnesium concentration in the urine may be quite high; sodium replaces magnesium under cold stress. During cold stress, sodium and chloride move into the urine independently of each other.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00360775
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  • 6
    Electronic Resource
    Electronic Resource
    Analysis of genetic recombination in maize populations using molecular markers (1992)
    Springer
    Theoretical and applied genetics 84 (1992), S. 65-72 
    Details
    ISSN: 1432-2242
    Keywords: Variation ; Recombination frequency ; Environmental effects ; Maize
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Variation in recombination rate is important to plant breeders since a major objective is to obtain favorable recombinants of linked genes. The ability to increase recombination (R) in circumstances in which favorable and unvavorable genes are linked (Corn Belt x exotic populations) and to decrease recombination when many favorable genes are linked (narrow-based, elite populations) would be of immense value. However, the concept of variation in recombination frequencies between linked genes has received limited attention despite its implications in breeding and genetic linkage studies. Molecular techniques have allowed better estimations of this variation. In this study, attempts were made to characterize: (1) the R values in the Pgm1-Adh1 and Adh1-Phi1 adjacent regions of chromosome 1 and the Idh2-Mdh2 region of chromosome 6 in F2 families of three maize (Zea mays L.) populations; (2) the environmental effect on R values of F2s from two populations. One population, NSO, was a Corn Belt synthetic, and the other two populations, CBMEX3 and CBCAR5, were composites from crosses between Corn Belt and exotic germ-plams. Wide ranges of estimated recombination ( $$\hat R$$ ) values were observed among families in each population for all three chromsomal regions. The distribution of $$\hat R$$ values for the Pgm1-Adh1 region showed that the F2 families of each population fell into two broad categories: 0.30–0.50 and 0.02–0.20. No intermediates (0.21–0.29) were found. The distributions were almost normal for the Adh1-Phi1 and the Idh2-Mdh2 regions. It would appear that the major dispersion in the Pgm1-Adh1 region was controlled by the effects of a single gene, while the Adh1-Phi1 and Idh2-Mdh2 regions were only affected by polygenes. No correlation was found between recombination values of the two adjacent regions, indicating that the genes affecting recombination for the Pgm1-Adh1 region may be specific for that region. For the Pgm1-Adh1 region, no differences in $$\hat R$$ values were found among the three populations. For the Adh1-Phi1 region, $$\hat R$$ frequencies of CBMEX3 and NSO were not significantly different, but both had significantly greater $$\hat R$$ values than CBCAR5. For the Idh2-Mdh2 region, CBMEX3 was significantly different from NSO. There were significant differences between some paired F2 families within each population for each chromosome region. No significant differences in response to the two environments were detected in CBMEX3 and NSO for either region in chromosome 1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00223982
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  • 7
    Electronic Resource
    Electronic Resource
    Measurement of cell proliferation in gastric carcinoma: comparative analysis of Ki-67 and proliferative cell nuclear antigen (PCNA) (1992)
    Springer
    Journal of molecular histology 24 (1992), S. 93-101 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Immunostaining to identify nuclear antigens expressed throughout the cell cycle provides a convenient way of assessing proliferating kinetics in tumours. We studied proliferation activity of gastric carcinomas by Ki-67 and PCNA immunostaining and the two methods were compared. The mode of tissue preparation differed, fresh frozen for Ki-67 and formalin-fixed paraffin-embedded for PCNA. Immunostaining with avidin-biotin was used in both. The labelling index (LI) and a semi-quantitative grading of cell proliferation were assessed in both markers. Significant correlation was shown between LI and grading with either Ki-67 and PCNA. However, no correlation was found between PCNA and Ki-67. This lack of relationship between the two markers may be attributed to a number of factors. 1. The most likely is the marked inter- and intra-tumour heterogeneity of gastric carcinomas reflected in high standard deviation values. 2. Preparation of tissue and small size sampling with Ki-67. 3. Long life of PCNA leading to detection of cells that have recently left the cell cycle. 4. One may be observing deregulated expression of DNA as seen in certain tumours. PCNA offers the advantage of being applicable to archival material.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01082445
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  • 8
    Electronic Resource
    Electronic Resource
    Factors affecting the thermal contraction of keratin fibres (1969)
    Springer
    Colloid & polymer science 229 (1969), S. 34-38 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Zusammenfassung Die Technik der Bestimmung der relativen Schmelztemperaturen aus thermischer Kontraktion wurde auf vernetzte Keratinfasern angewendet. Die Einführung zusätzlicher Vernetzungen durch Formaldehyd ergibt eine vermehrte thermische Stabilität, doch nur für gewisse Bedingungen der Behandlung. Keine Änderung der thermischen Stabilität wird durch Einführung von Vernetzungen bei anderen Verfahren beobachtet. Jedoch erhöht die Reduktion des Wassergehaltes die thermische Stabilität in Wasser. Es wird vermutet, daß die Vernetzungen, die die thermische Stabilität beeinflussen, sehr eng mit der Struktur des Keratins verknüpft sind und diese durch FormaldehydBehandlung mit Formalhydrat in einer monomeren oder Mono-Hydrat-Form möglich ist. Formaldehyd-Behandlung stellt voll den Verlust an thermischer Stabilität von teilweise reduzierter Wolle wieder her, ein Effekt, der nicht bei anderen Vernetzungsarten eintritt.
    Notes: Abstract The technique of determining relative melting temperatures from thermal contraction data has been applied to crosslinked keratin fibres. The introduction of additional crosslinks by formaldehyde results in an increased thermal stability but only for certain conditions of treatment. No change of thermal stability is observed following the introduction of crosslinks by other treatments, but the reduction of water content increases the thermal stability in water. It is suggested that the crosslinks affecting thermal stability are those closely associated with the helical structure of keratin and this is achieved by formaldehyde treatments in which formaldehyde is in a monomeric or monohydrate form. Formaldehyde treatment fully restores the loss of thermal stability of partially reduced wool, an effect not achieved by other crosslinking treatments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01542504
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  • 9
    Electronic Resource
    Electronic Resource
    Robot calibration using an automatic theodolite (1994)
    Springer
    The international journal of advanced manufacturing technology 9 (1994), S. 114-125 
    Details
    ISSN: 1433-3015
    Keywords: Robotics ; Calibration ; Vision
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The Vision Based Automatic Theodolite (VBAT) is an automatic partial pose measurement system for robot calibration. It uses low resolution rotation stages and resolution enhancement from a vision system to determine the line-of-sight to a spherical illuminated target. Automatic tracking, focusing, and centring provide the calibration system with speed, reliability, and repeatability. A kinematic model of the VBAT is described which includes both the mechanical parts of the system and the optics, using a modified Denavit-Hartenberg approach. All parameters in the VBAT model are identified and embedded into the system controller producing an instrument of 2 arc second accuracy. The system is then used in a conventional manner to calibrate a six degree of freedom PUMA robot, and the results compared to another calibration of the same arm by a coordinate measuring machine with repeatability and accuracy of 0.02 mm. The calibration using the VBAT enhances the accuracy of the PUMA to within 0.2 mm of that produced by the CMM calibration, compared to an accuracy of 14 mm prior to calibration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01750418
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  • 10
    Electronic Resource
    Electronic Resource
    Role of chromosome 3A in stomatal resistance of winter wheat (1992)
    Springer
    Euphytica 62 (1992), S. 59-62 
    Details
    ISSN: 1573-5060
    Keywords: Triticum aestivum ; stomatal resistance ; chromosome 3A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Leaf stomatal resistance, through transpiration and photosynthesis control, constitutes a major factor of productivity and adaptation in wheat. The aim of the investigations reported here was to identify chromosomal effects on the expression of the maximum stomatal resistance, determined under optimum conditions of irradiance and water supply. Leaf stomatal resistance was measured, on wheat grown in pots under natural and well-watered conditions, using a LI-COR LI-6200 portable photosynthesis system under a saturating light〉1400 μmol m-1 s-2. Reciprocal sets of chromosome substitution lines between two hard red winter wheat cultivars, Wichita and Cheyenne, were used to identify the chromosomes involved in the expression of this trait. The two parental cultivars were significantly different for the parameter investigated. Chromosome 3A appeared to be involved in the expression of the stomatal resistance value under optimum conditions. Taking into account the relationships previously established between this parameter and some agronomic traits, chromosome 3A might be involved directly in productivity-determining processes or in the adaptation to water conditions, in wheat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00036088
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