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  • 1
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    Monoclonal antibodies directed against surface molecules of multicell spheroids (1994)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The objective of this project is to generate a library of monoclonal antibodies (MAbs) directed against surface molecules of tumor and transformed cells grown as multicell spheroids (MCS). These MCS are highly organized, 3-dimensional multicellular structures which exhibit many characteristics of in vivo organized tissues not found in conventional monolayer or suspension culture. Therefore MCS make better in vitro model systems to study the interactions of mammalian cells, and provide a functional assay for surface adhesion molecules. This project also involves investigations of cell-cell interactions in a gravity-based environment. It will provide a base of scientific information necessary to expand the focus of the project in future years to microgravity and hypergravity-based environments. This project also has the potential to yield important materials (e.g., cellular products) which may prove useful in the diagnosis and/or treatment of certain human diseases. Moreover, this project supports the training of both undergraduate and graduate students; thus, it will assist in developing a pool of future scientists with research experience in an area (gravitational biology) of interest to NASA.
    Keywords: LIFE SCIENCES (GENERAL)
    Type: NASA-CR-196385 , NAS 1.26:196385
    Format: application/pdf
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  • 2
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    Monoclonal antibodies directed against surface molecules of multicell spheroids (1993)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The objective of this project is to generate a library of monoclonal antibodies (MAb's) to surface molecules involved in the cell-cell interactions of mammalian cells grown as multicell spheroids (MCS). MCS are highly organized 3-dimensional multicellular structures which exhibit many characteristics in vivo tissues not found in conventional monolayer or suspension culture. They also provide a functional assay for surface adhesion molecules. In brief, MCS combine the relevance of organized tissues with the accuracy of in vitro methodology. Further, one can manipulate these MCS experimentally to discern important information about their biology.
    Keywords: LIFE SCIENCES (GENERAL)
    Type: NASA-CR-193560 , NAS 1.26:193560
    Format: application/pdf
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  • 3
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    Monoclonal antibodies directed against surface molecules of multicell spheroids (1994)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The objective of this project is to generate a library of monoclonial antibodies (MAbs) directed against surface molecules of tumor and transformed cells grown as multicell spheroids (MCS). These MCS are highly organized, 3-dimensional multicellular structures which exhibit many characteristics of in vivo organized tissues which are not found in conventional monolayer or suspension culture. In brief, MCS combine the relevance or organized tissues with in vitro methodology making the MCS a good model system to study the interactions of mammalian cells, and thereby provide a functional assay for surface adhesion molecules. This project also involves investigations of cell-cell interactions in a gravity-based environment. It will provide an important base of scientific information for future comparative studies on the effects of hypergravity and simulated microgravity environments on cell-cell interactions. This project also has the potential to yield important materials (e.g. cellular products) which may be useful for the diagnosis and/or treatment of certain human diseases. Moreover, this project supports the training of one undergraduate and one graduate student; thus, it will also assist in developing a pool of future scientists with research experience in gravitational biology research.
    Keywords: LIFE SCIENCES (GENERAL)
    Type: NASA-CR-197367 , NAS 1.26:197367
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 4
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    Unknown
    Monoclonal antibodies directed against surface molecules of multicell spheroids (1993)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The objective of this project is to generate a library of monoclonal antibodies (MAbs) to surface molecules of mammalian tumor and transformed cells grown as multicell spheroids (MCS). These MCS are highly organized, three dimensional multicellular structures which exhibit many characteristics of in vivo organized tissues not found in conventional monolayer or suspension culture; therefore, MCS make better in vitro model systems to study the interactions of mammalian cells. Additionally, they provide a functional assay for surface adhesion molecules.
    Keywords: LIFE SCIENCES (GENERAL)
    Type: NASA-CR-195102 , NAS 1.26:195102
    Format: application/pdf
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  • 5
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    Adaptations of young adult rat cortical bone to 14 days of spaceflight (1992)
    In:  Other Sources
    Details
    Publication Date: 2019-08-28
    Description: To determine whether mature humeral cortical bone would be modified significantly by an acute exposure to weightlessness, adult rats (110 days old) were subjected to 14 days of microgravity on the COSMOS 2044 biosatellite. There were no significant changes in peak force, stiffness, energy to failure, and displacement at failure in the flight rats compared with ground-based controls. Concentrations and contents of hydroxyproline, calcium, and mature stable hydroxylysylpyridinoline and lysylpyridinoline collagen cross-links remained unchanged after spaceflight. Bone lengths, cortical and endosteal areas, and regionl thicknesses showed no significant differences between flight animals and ground controls. The findings suggest that responsiveness of cortical bone to microgravity is less pronounced in adult rats than in previous spaceflight experiments in which young growing animals were used. It is hypothesized that 14 days of spaceflight may not be sufficient to impact the biochemical and biomechanical properties of cortical bone in the mature rat skeleton.
    Keywords: LIFE SCIENCES (GENERAL)
    Type: Journal of Applied Physiology, Supplement (ISSN 8750-7587); 73; 2 Au
    Format: text
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