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Possible geothermal resources in the Coast Plutonic Complex of southern British Columbia, Canada (1978)

Lewis, T. J. ; Judge, A. S. ; Souther, J. G.

Springer

Pure and applied geophysics 117 (1978), S. 172-179

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ISSN: 1420-9136

Keywords: Coast Plutonic Complex ; Quaternary volcanism ; Plate tectonics ; Heat flow ; Heat production

Source: Springer Online Journal Archives 1860-2000

Topics: Geosciences , Physics

Notes: Abstract In southern British Columbia the terrestrial heat flow is low (44 mW m−2) to the west of the Coast Plutonic Complex (CPC), average in CPC (50–60 mW m−2),and high to the east(80–90 mW m−2). The average heat flow in CPC and the low heat generation (less than 1 μW m−3) indicate that a relatively large amount of heat flows upwards into the crust which is generally quite cool. Until two million years ago the Explorer plate underthrust this part of the American plate, carrying crustal material into the mantle. Melted crustal rocks have produced the inland Pemberton and Garibaldi volcanic belts in the CPC. Meager Mountain, a volcanic complex in the CPC 150 km north of Vancouver, is a possible geothermal energy resource. It is the product of intermittent activity over a period of 4 My, the most recent eruption being the Bridge River Ash 2440 y B.P. The original explosive eruption produced extensive fracturing in the granitic basement, and a basal explosion breccia from the surface of a cold brittle crust. This breccia may be a geothermal reservoir. Other volcanic complexes in the CPC have a similar potential for geothermal energy.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00879744

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Beta-adrenergic receptors: Regulatory role of agonists (1978)

Lefkowitz, Robert J. ; Limbird, Lee E. ; Williams, Lewis T. ; [et al.]

New York, N.Y. : Wiley-Blackwell

Journal of Supramolecular Structure 8 (1978), S. 501-510

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ISSN: 0091-7419

Keywords: receptor ; catecholamines ; agonist ; adenylate cyclase ; erythrocyte ; Life Sciences ; Molecular Cell Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Chemistry and Pharmacology , Medicine

Notes: Direct radioligand binding studies have been used to probe the molecular mechanisms whereby agonist catecholamines regulate the function of betaadrenergic receptors in a model system, the frog erythrocyte. The unique characteristics of agonist as opposed to antagonist action are first, the ability to stimulate the adenylate cyclase through the receptor and second, the ability to desensitize the system by alterations induced in beta-adrenergic receptors. These properties of agonist are not shared by antagonist despite the high affinity and specificity of antagonist binding to the beta-adrenergic receptors. Agonist and antagonist receptor complexes may be distinguished in a variety of ways including differences in their sensitivity to regulatory guanine nucleotides and also by gel chromatography on AcA 34 Ultragel. The agonist receptor complex appears to elute from the columns with an apparently increased size. A “dynamic receptor affinity model” of beta-adrenergic receptor action is proposed which features several distinct conformational states of the receptor. Agonists have much higher affinity for the physiologically active or coupled state of the receptor, whereas antagonists have equal affinity for both. In addition, a third “desensitized” state of the receptor is also postulated to exist.

Additional Material: 5 Ill.