Publication Date:
2016-04-06
Description:
Article The formation of blood vessels in tumours, angiogenesis, is a promising target for therapy. Here, the authors show that microRNA192 has anti-angiogenic functions and negatively regulates EGR1 and HOXB9 , and that delivery of this microRNA to tumours in vivo can reduce angiogenesis and tumour growth. Nature Communications doi: 10.1038/ncomms11169 Authors: Sherry Y. Wu, Rajesha Rupaimoole, Fangrong Shen, Sunila Pradeep, Chad V. Pecot, Cristina Ivan, Archana S. Nagaraja, Kshipra M. Gharpure, Elizabeth Pham, Hiroto Hatakeyama, Michael H. McGuire, Monika Haemmerle, Viviana Vidal-Anaya, Courtney Olsen, Cristian Rodriguez-Aguayo, Justyna Filant, Ehsan A. Ehsanipour, Shelley M. Herbrich, Sourindra N. Maiti, Li Huang, Ji Hoon Kim, Xinna Zhang, Hee-Dong Han, Guillermo N. Armaiz-Pena, Elena G. Seviour, Sue Tucker, Min Zhang, Da Yang, Laurence J. N. Cooper, Rouba Ali-Fehmi, Menashe Bar-Eli, Ju-Seog Lee, Prahlad T. Ram, Keith A. Baggerly, Gabriel Lopez-Berestein, Mien-Chie Hung, Anil K. Sood
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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