Publication Date:
2019
Description:
Abstract
We conducted a prospective evaluation of drug‐induced severe hyponatremia (ADR‐SS), through the Prospective Pharmacovigilance Program from Laboratory Signals at Hospital over a period of 10yrs. Cases of serum sodium Na(s)〈116mmol/l were recorded from July‐2007 to June‐2017(1stperiod). Also cases of Na(s)116‐122mmol/l were recorded from July‐2012 to June‐2017(2ndperiod). Drugs were the primary cause of severe hyponatremia. The incidence rate of Na(s)〈116mmol/l by drugs was increased 3‐fold over the decade. Comparing with other causes of hyponatremia, patients with ADR‐SS in the 1stperiod were older (79y[IQR68.6–89vs.65y[IQR48–81];p〈.001) and were more often women (70.8%vs.48.9%,p〈.001); in the 2ndperiod were also older (79y[IQR65.3–89]vs.63y[IQR 46–80.6];p〈.001) and were more often women (70%vs.53%,p=.002), and ADR‐SS occurred more often in summer. The most frequent therapeutic groups of related drugs were the cardiovascular system and nervous system. The 65.3% in 1st and 71.2% in 2nd of the ADR‐SS cases responded to hydration and had been diagnosed with hypovolemic hyponatremia.
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Print ISSN:
0009-9236
Electronic ISSN:
1532-6535
Topics:
Chemistry and Pharmacology
,
Medicine
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