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  • Articles  (9)
  • atenolol  (9)
  • Springer  (9)
  • Elsevier
  • 2015-2019
  • 2005-2009
  • 1980-1984  (9)
  • Medicine  (9)
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  • Articles  (9)
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Keywords
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  • Springer  (9)
  • Elsevier
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  • 1
    Electronic Resource
    Electronic Resource
    Effect of atenolol and propranolol on the systemic and regional hemodynamics (1983)
    Springer
    Bulletin of experimental biology and medicine 96 (1983), S. 949-951 
    Details
    ISSN: 1573-8221
    Keywords: atenolol ; propranolol ; hemodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00833046
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of the β-adrenoblocker atenolol on area of myocardial necrosis in transient and permanent coronary occlusion (1984)
    Springer
    Bulletin of experimental biology and medicine 97 (1984), S. 65-67 
    Details
    ISSN: 1573-8221
    Keywords: coronary occlusion ; myocardial infarction ; atenolol ; area of zone of necrosis ; anti-ischemic action
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00830246
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of cardioselective and non-cardioselective beta-blockade on adrenaline-induced metabolic and cardiovascular responses in man (1981)
    Springer
    European journal of clinical pharmacology 20 (1981), S. 17-22 
    Details
    ISSN: 1432-1041
    Keywords: beta-blocker ; atenolol ; pindolol ; plasma free fatty acids ; growth hormone ; blood glucose ; myocardial oxygen consumption ; myocardial efficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In 12 normal volunteers the interaction between the metabolic and cardiovascular effects of adrenaline and either a cardioselective (atenolol 150 mg p. o. for 1 week) or a non-selectiveβ-blocker with intrinsic sympathomimetic activity (pindolol 15 mg p. o. for 1 week) were studied. Equiactive doses of theβ-blockers were investigated with respect to their metabolic effects. There were profound differences in the metabolic profile of the two substances: the non-cardioselective beta-blocker caused significant inhibition of the lipolytic, glycogenolytic and the growth hormone-releasing effects of adrenaline when compared to the cardioselective agent. The results indicate that, during non-cardioselective beta-blockade, metabolic effects occur which should favourably influence myocardial oxygen consumption by making myocardial performance more economical.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00554661
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  • 4
    Electronic Resource
    Electronic Resource
    Asthma and beta-blockers (1982)
    Springer
    European journal of clinical pharmacology 22 (1982), S. 501-509 
    Details
    ISSN: 1432-1041
    Keywords: atenolol ; metoprolol ; asthma ; bronchospasm ; blood pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a randomized, blind crossover study in 14 hypertensive patients with asthma, involving placebo and chronically administered (3 weeks) equipotent beta1-blocking doses of atenolol 100 mg once daily and metoprolol 100 mg bid, atenolol and metoprolol produced a similar fall in blood pressure. Atenolol caused significantly (p〈0.05) less bronchospasm in terms of fewer asthmatic attacks, more asthma-free days, less frequent sensations of moderate to very severe, wheeziness and less effect on the evening peak flow rate. It was concluded that, in patients with asthma who require beta blockade, atenolol is the preferred agent, co-prescribed with a beta2 stimulant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609622
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of adrenaline on myocardial oxygen consumption during selective and non-selective beta-adrenoceptor blockade comparison of atenolol and pindolol (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 29-34 
    Details
    ISSN: 1432-1041
    Keywords: myocardial oxygen consumption ; beta-adrenoceptor blockade ; atenolol ; pindolol ; adrenaline ; free fatty acids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of adrenaline on myocardial oxygen consumption (MVO2) during selective and non-selective beta-adrenoceptor blockade was examined in 26 patients with angina pectoris. Cardiac venous flow was measured by thermodilution and blood was sampled for metabolic studies. Thirteen patients were given atenolol 62.5 µg/kg i.v. and the other 13 patients pindolol 7.5 µg/kg i.v. Measurements were repeated before and during infusion of adrenaline 0.1 µg/kg/min. Compared to the control situation, adrenaline increased MVO2 more in atenolol-treated (39%) than in pindolol-treated patients (11%). This was partly due to augmented external cardiac work. Arterial FFA was considerably increased in the atenolol group (105%), but was unchanged in the pindolol group, suggesting an additional metabolic mechanism. Thus, adrenaline stimulation, which is comparable to that found in acute myocardial infarction, increases MVO2 more during selective than non-selective beta-blockade.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02395202
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  • 6
    Electronic Resource
    Electronic Resource
    Relative activities of atenolol and metoprolol on the cardiovascular system of man (1981)
    Springer
    European journal of clinical pharmacology 20 (1981), S. 9-15 
    Details
    ISSN: 1432-1041
    Keywords: atenolol ; metoprolol ; heart rate ; exercise ; systolic blood pressure ; volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects or oral atenolol (100 mg once/day) and metoprolol (100 mg once/day, 100 mg twice/day and 300 mg once/day) have been compared with placebo on the heart rate and systolic blood pressure responses to exercise in 5 healthy volunteers. The drugs were given for 5 days in a double blind randomised fashion with each volunteer receiving each dose of drug. Measurements were made after the first dose on day 1 and after 5 days of dosing. The results on both heart rate and systolic blood pressure showed that overall (over a 24 h period) after acute (day 1) or after chronic (5 days) dosing, atenolol 100 mg once/day, metoprolol 100 mg twice/day and 300 mg once/day, were equivalent asβ-adrenoceptor blocking doses. Thus milligram for milligram atenolol and metoprolol do not produce equivalent blockade on the cardiovascular system of man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00554660
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of adrenaline on myocardial oxygen consumption during selective and non-selective beta-adrenoceptor blockade comparison of atenolol and pindolol (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 29-34 
    Details
    ISSN: 1432-1041
    Keywords: myocardial oxygen consumption ; beta-adrenoceptor blockade ; atenolol ; pindolol ; adrenaline ; free fatty acids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of adrenaline on myocardial oxygen consumption (MVO2) during selective and non-selective beta-adrenoceptor blockade was examined in 26 patients with angina pectoris. Cardiac venous flow was measured by thermodilution and blood was sampled for metabolic studies. Thirteen patients were given atenolol 62.5 µg/kg i.v. and the other 13 patients pindolol 7.5 µg/kg i.v. Measurements were repeated before and during infusion of adrenaline 0.1 µg/kg/min. Compared to the control situation, adrenaline increased MVO2 more in atenolol-treated (39%) than in pindolol-treated patients (11%). This was partly due to augmented external cardiac work. Arterial FFA was considerably increased in the atenolol group (105%), but was unchanged in the pindolol group, suggesting an additional metabolic mechanism. Thus, adrenaline stimulation, which is comparable to that found in acute myocardial infarction, increases MVO2 more during selective than non-selective beta-blockade.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00553150
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  • 8
    Electronic Resource
    Electronic Resource
    Double-blind comparison of once-daily bopindolol, pindolol and atenolol in essential hypertension (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 529-534 
    Details
    ISSN: 1432-1041
    Keywords: beta-adrenoceptor blocking agents ; hypertension ; adverse reactions ; atenolol ; bopindolol ; pindolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The efficacy of once-daily bopindolol, a nonselectiveβ-adrenoceptor blocking agent with partial agonist activity, and of pindolol and atenolol in the treatment of essential hypertension has been compared. 369 patients were investigated in a double-blind parallel-group study. The treatment period was 10 weeks. Blood pressure normalisation (diastolic BP equal to or less than 90 mmHg) was to be achieved by a stepwise increase in the dose of the test drugs, and, if required, by addition of a diuretic. Normalisation of blood pressure was achieved in 71 to 76% of the subjects, with no significant differences between bopindolol, pindolol, and atenolol. Special attention was given to evaluation of side effects by using two methods for registration of all adverse events during the study. A low incidence of drug-induced side effects was observed, with no significant difference between bopindolol, pindolol, and atenolol. There was no evidence of unsuspected adverse reactions due to bopindolol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00556887
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  • 9
    Electronic Resource
    Electronic Resource
    Use of fixed doses of beta blocking drugs in the treatment of hypertension (1981)
    Springer
    European journal of clinical pharmacology 21 (1981), S. 93-96 
    Details
    ISSN: 1432-1041
    Keywords: atenolol ; penbutolol ; hypertension ; beta-blockers ; intrinsic sympathomimetic activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Atenolol 100 mg and penbutolol 40 mg given once a day were both effective in controlling moderate hypertension, as judged by a randomised controlled, double-blind trial in 45 patients treated for six weeks. Both drugs significantly reduced the resting supine and erect blood pressures. No serious adverse effects could be attributed to either drug. Bradycardia occurred more frequently with atenolol than with penbutolol. Penbutolol, which possesses intrinsic sympathomimetic activity, may be useful in the treatment of patients in whom some other beta-blocker has failed to bring about adequate control of the blood pressure, despite marked bradycardia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637507
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