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  • 1
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    Postprandial Lipemia is Modified by the Presence of the APOB-516C/T Polymorphism in a Healthy Caucasian Population (2007)
    Springer
    Details
    Publikationsdatum: 2007-02-10
    Print ISSN: 0024-4201
    Digitale ISSN: 1558-9307
    Thema: Biologie , Chemie und Pharmazie
    Publiziert von Springer
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  • 2
    Digitale Medien
    Digitale Medien
    Kalman filtering-aided time-resolved solid-surface room temperature phosphorimetry for simultaneous determination of tetracyclines in solution (1993)
    Springer
    Microchimica acta 112 (1993), S. 47-54 
    Details
    ISSN: 1436-5073
    Schlagwort(e): chemometrics ; multicomponent analysis ; Kalman filtering ; tetracyclines determination ; room temperature phosphorescence
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Tetracycline, chlortetracycline and oxytetracycline react with Eu (III) to form complexes which exhibit analytically useful room temperature phosphorescence (RTP). The RTP features of the three complexes are similar and the RTP spectra completely overlap. However, their three phosphorescence decay rates are quite different. These differences are utilized here to analyze the time-resolved RTP data by Kalman filtering. Simultaneous quantification of all the three complexes is demonstrated and a method is proposed for the simultaneous determination of the three tetracyclines in mixtures by RTP optosensing. Analytical errors observed are within ± 5%.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01243320
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  • 3
    Digitale Medien
    Digitale Medien
    Potassium-selective optrode based on an immobilized fluorogenic crown ether (1994)
    Springer
    Microchimica acta 113 (1994), S. 211-222 
    Details
    ISSN: 1436-5073
    Schlagwort(e): potassium ; fluorogenic crown ethers ; optical sensors ; human serum ; urine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract A new optical sensor phase for potassium ions has been developed based on the immobilization of the pH-dependent fluorogenic crown ether 4-acryloylamidobenzo-18-crown-6 on the non-ionic polymeric resin Amberlite XAD-2. Two different optical designs, a flow-through sensor and a fibre optic probetype sensor (optrode), have been constructed and their analytical performance characteristics have been evaluated. The resulting fluorimetric sensors for K+ ions exhibited detection limits of 0.4 or 0.8 μM of K+ (16 μg/l or 31 μg/l), depending on the design, while the linear response occurred from 1 to 25 μM of the metal concentrations. The precision, evaluated as the relative standard deviation of measurements of K+ levels at around ten times the detection limit (e.g. 5 μM), turned out to be around ±2%. Advantageous features of this fluorimetric sensing phase and optrode include ease of construction, simplicity of use, reversibility, short response times (ca. 1 min full scale deflection) selectivity and operational stability, suitable for sensing potassium at low levels in complex matrices such as biological fluids. The fluorimetric optical sensor has been successfully applied to the direct determination of potassium in clinically important samples (serum and urine) and in natural waters. Very good accuracy has been obtained just using adequate synthetic aqueous potassium standards for calibration.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01243612
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  • 4
    Digitale Medien
    Digitale Medien
    Enhancement of propoxyphene bioavailability by ethanol (1991)
    Springer
    European journal of clinical pharmacology 41 (1991), S. 147-152 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Propoxyphene-Ethanol Interaction ; bioavailability ; healthy volunteers ; psychomotor performance drug interaction
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The interaction between a single oral dose of 130 mg propoxyphene and 0.5 g/kg body weight ethanol was investigated in 12 healthy male volunteers by 9 objective performance tests, 8 visual analogue self-rating scales and the measurement of plasma propoxyphene, norpropoxyphene and ethanol concentrations, using a double-blind threeway crossover design. Volunteers were each given one of three treatments, propoxyphene + ethanol, placebo + ethanol and propoxyphene alone, separated by a two week interval. The performance tests were completed before and 1.25 and 4 h after drug intake, and the self-rating scales before and 1.25, 4 and 10 h after it. Ethanol was shown to enhance the bioavailability of propoxyphene by 25% probably by reducing its first-pass metabolism. However, despite this pharmacokinetic effect no pharmacodynamic interaction was found. Subjective ratings disclosed that the effect of ethanol on physical and mental sedation predominated over the effects of propoxyphene.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00265908
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  • 5
    Digitale Medien
    Digitale Medien
    Copper(II) and cadmium(II) complexes of 2-benzylthio-4-formyl-1-p-methoxyphenylimidazole: crystal structure, spectral properties and thermal behaviour (1993)
    Springer
    Transition metal chemistry 18 (1993), S. 481-484 
    Details
    ISSN: 1572-901X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The coordinative capacity of 2-benzylthio-4-formyl-1-p-methoxyphenylimidazole (ALME) with several transition metal ions has been investigated and has led to only copper(II) and cadmium(II) complexes of general formula [MIICl2(ALME)2]·nH2O. These compounds were studied by spectral (i.r., u.v.-vis. n.i.r. and e.p.r.) and thermal methods (t.g., d.t.g. and d.s.c.) as well as magnetic susceptibility measurements. The crystal structure of the copper complex has been solved, although a full refinement of the structure has not been possible as very few measured reflections were observed. The structure consists of discrete [CuCl2-(ALME)2] units in which Cu(II) ion is 4 + 2 Cl2N2O2 surrounded [Cu{ie481-01}Cl(1), 2.28(1) Å; Cu{ie481-02}Cl(2), 2.29(1) Å; Cu{ie481-03}N, 2.00(2) Å; Cu{ie481-04}O, 2.71(2) Å]. The ALME ligand acts as bidentate chelator through the N(3) imidazolic atom and the oxygen of the formyl group, the Cu{ie481-05}O interaction being very weak. Water molecules have not been localized.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00136609
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  • 6
    Digitale Medien
    Digitale Medien
    Different phosphorylation behaviour of regulatory subunit isoforms of type 11 cAMP-dependent protein kinase from bovine heart (1990)
    Springer
    Molecular and cellular biochemistry 96 (1990), S. 25-33 
    Details
    ISSN: 1573-4919
    Schlagwort(e): cAMP-dependent protein kinase ; autophosphorylation ; limited proteolysis ; isoforms of regulatory subunits
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract Two forms of the regulatory subunit of the type II cAMP-dependent protein kinase (RII55 and RII52) were identified from bovine heart by gel electrophoretic behaviour. After autophosphorylation the RII55 isoform migrated more slowly (RII55/57) while the migration of RII52 isoform did not shift. Both isoforms showed different affinity for cAMP. The RII55/57 isoform was eluted from a cAMP-agarose column at 10 mM cAMP at low ionic strenght whereas the RII52 isoform required cAMP, plus 2 M NaCl. Partial proteolysis, using trypsin or formic acid, of autophosphorylated regulatory subunit isoforms resulted in different cleavage pattern as determined by peptide mapping. However, the V8125I-peptides patterns of both isoforms are quite similar. Incubation of partially purified holoenzyme with 10 nM [γ-32P]ATP (low ATP concentration) yielded a single band of Mr = 57,000 which corresponds to the RII55/57 isoform. The incubation, however, at 20 µM [γ-32P]ATP yielded two phosphobands corresponding to both RII55/57 and RII52 isoforms. The phosphorylation of RII52 took place with a lower efficiency and was more sensitive to the cAMP than the corresponding phosphorylation of the RII55/57.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00228450
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  • 7
    Digitale Medien
    Digitale Medien
    Integration of lipid metabolism in the mammary gland and adipose tissue by prolactin during lactation (1990)
    Springer
    Molecular and cellular biochemistry 93 (1990), S. 185-194 
    Details
    ISSN: 1573-4919
    Schlagwort(e): prolactin ; bromocryptine ; adipocytes and acini ; pentose phosphate shunt activity ; lipogenesis ; phospholipid turnover ; insulin responsiveness
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract Prolactin deficiency, induced by bromocryptine treatment, brought about reciprocal changes in the ability of adipocytes and acini isolated from lactating rats to synthesize lipids. The capacity to synthesize fatty acids and phospholipids decreased in the mammary gland and increased in adipocytes by bromocryptine treatment. In the mammary gland, the maximum potential activity of the pentose shunt as well as the specific activities of the pathway dehydrogenases were significantly reduced by bromocryptine treatment. Simultaneously, adipose tissue increased its lipogenic capacity but neither the maximum potential of the shunt nor the specific activities of the pentose phosphate shunt dehydrogenases were significantly changed with respect to the control lactating rats. Thus, a differential regulatory mechanism(s) of the pentose phosphate shunt activity appears to operate in these two tissues. Adipocytes from lactating rats showed a poor responsiveness to insulin in terms of lipid synthesis from glucose. In contrast, in adipocytes from bromocryptine treated rats insulin was able to increase lipid synthesis (105%). Sheep prolactin administration ‘in vivo’ partially reversed the effects of bromocryptine. These data suggest that prolactin mediates adipocytes resistance to insulin during lactation. Phospholipid synthesis, as occurred in fatty acid synthesis, is increased in adipose tissue and decreased in mammary gland by bromocryptine treatment. However, α-adrenergic stimulation increases phosphatidylinositol turnover to about the same percentages in both mammary gland acini and adipocytes from lactating rats independently of bromocryptine treatment.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00226191
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  • 8
    Digitale Medien
    Digitale Medien
    Fractionation in two-phase systems of red cells during rat development: Changes in pyruvate kinase and bisphosphoglycerate mutase activities in relation to red cell switching (1990)
    Springer
    Molecular and cellular biochemistry 94 (1990), S. 37-44 
    Details
    ISSN: 1573-4919
    Schlagwort(e): counter-current distribution ; two-phase systems ; erythrocytes ; development ; bisphosphoglycerate mutase ; pyruvate kinase
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Summary An inverse relationship between 2,3-bisphosphoglycerate levels and the ratio calculated from pyruvate kinase and bisphosphoglycerate mutase activities has been observed in red populations of rats during animal development. Counter-current distribution in aqueous two-phase systems of these cells populations shows a displacement of distribution profiles towards the high-numbered cavities of the rotor as animal ages. Heterogeneity of cells after distribution is only observed during the switching process from fetal to adult red cells taking place along the postnatal stage of development. Values for the pyruvate kinase/bisphosphoglycerate mutase ratio in these fractions suggest the separation of fetal (liver) from adult (bone marrow) red cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00223560
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  • 9
    Digitale Medien
    Digitale Medien
    Dipyridamole stimulates types II cAMP-dependent protein kinase in vitro (1992)
    Springer
    Molecular and cellular biochemistry 109 (1992), S. 9-15 
    Details
    ISSN: 1573-4919
    Schlagwort(e): cAMP-dependent protein kinase ; dipyridamole ; lipid metabolism ; autophosphorylation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract Dipyridamole activates in vitro type II CAMP-dependent protein kinase. This agent stimulates the autophosphorylation of the regulatory subunit in the presence of CAMP but not so in the absence of the cyclic nucleotide. The activation was also observed with exogenous substrates such as casein, histone 2A and MAP 2. This stimulation did not seem to be related to the cAMP binding to the R II subunit of the enzyme. Competition binding experiments showed that dipyridamole does not compete with adenosine for the A1 receptor. The results suggest that the reported regulatory properties of dipyridamole on lipid metabolism (González-Nicolás et al. Int J Biochem 21: 883–888, 1989) might be mediated through a direct action — an activation — on the catalytic subunit of a cAMP-dependent protein kinase.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00230868
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  • 10
    Digitale Medien
    Digitale Medien
    Protection and enhancement of ribulose 1,5 bisphosphate carboxylase activity by exogenous proteins (1991)
    Springer
    The protein journal 10 (1991), S. 287-290 
    Details
    ISSN: 1573-4943
    Schlagwort(e): Ribulose 1,5 bisphosphate carboxylase/oxygenase ; enzyme protection ; enzyme inactiviation ; protein oxidation ; protein structural stability (Citrus)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract When assayedin vitro, the activity of the photosynthetic enzyme ribulose 1,5 bisphosphate carboxylase/oxygenase is both enhanced and protected from spontaneous decay by exogenous proteins such as hemoglobin, serum albumin, and aldolase. Other proteins and amino acids tested are either ineffective (lysozyme, ferritin, lysine, and cysteine) or afford only partial protection (catalase, glycine, and phenylalanine). Protective proteins do not bind to, or exchange disulfides with, ribulose 1,5 bisphosphate carboxylase/oxygenase. Since their effect can be mimicked by reductively treated detergents such as Triton X-100, it appears that proteins protect from decay by quenching the spontaneous oxidative degradation and inhibiting surface adsorption which could lead to enzyme unfolding. Release of adsorbed molecules from the container surface is likely to be the cause of carboxylase activity enhancement.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01025627
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