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  • Landing statistics  (43)
  • Quantum optics, physics of lasers, nonlinear optics, classical optics  (30)
  • Chemistry
  • Mice
  • 2015-2019  (75)
  • 2010-2014  (19)
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  • 11
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    Mode invisibility and single-photon detection (2013)
    American Physical Society (APS)
    Details
    Publication Date: 2013-12-11
    Description: Author(s): Marvellous Onuma-Kalu, Robert B. Mann, and Eduardo Martín-Martínez We propose a technique to probe the quantum state of light in an optical cavity without significantly altering it. We minimize the interaction of the probe with the field by arranging a setting where the largest contribution to the transition probability is canceled. We show that we obtain a very go... [Phys. Rev. A 88, 063824] Published Tue Dec 10, 2013
    Keywords: Quantum optics, physics of lasers, nonlinear optics, classical optics
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
    Published by American Physical Society (APS)
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  • 12
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    Morphology of wave fronts and caustics associated with a circular wave refracted by an arbitrary curve: The two-dimensional axicon (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-11-04
    Description: Author(s): Gabriel Martínez-Niconoff, Gilberto Silva-Ortigoza, and Román Suárez-Xique In this work we use geometrical optics to study the global behavior of the morphology of the wave fronts and their respective caustic associated with the refraction of a circular wave propagating between two given optical media with constant refraction indexes, which are separated by an arbitrary cu... [Phys. Rev. A 90, 053803] Published Mon Nov 03, 2014
    Keywords: Quantum optics, physics of lasers, nonlinear optics, classical optics
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
    Published by American Physical Society (APS)
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  • 13
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    Surface solitons in quasiperiodic nonlinear photonic lattices (2012)
    American Physical Society (APS)
    Details
    Publication Date: 2012-01-05
    Description: Author(s): Alejandro J. Martínez and Mario I. Molina [Phys. Rev. A 85, 013807] Published Wed Jan 04, 2012
    Keywords: Quantum optics, physics of lasers, nonlinear optics, classical optics
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
    Published by American Physical Society (APS)
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  • 14
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    Mode invisibility as a quantum nondemolition measurement of coherent light (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-10-01
    Description: Author(s): Marvellous Onuma-Kalu, Robert B. Mann, and Eduardo Martín-Martínez We exploit geometric properties of quantum states of light in optical cavities to carry out quantum nondemolition measurements. We generalize the “mode-invisibility” method to obtain information about the Wigner function of a squeezed coherent state in a nondestructive way. We also simplify the appl... [Phys. Rev. A 90, 033847] Published Tue Sep 30, 2014
    Keywords: Quantum optics, physics of lasers, nonlinear optics, classical optics
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
    Published by American Physical Society (APS)
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  • 15
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    Broadband terahertz radiation from two-color mid- and far-infrared laser filaments in air (2018)
    American Physical Society (APS)
    Details
    Publication Date: 2018-06-19
    Description: Author(s): Alisée Nguyen, Pedro González de Alaiza Martínez, Illia Thiele, Stefan Skupin, and Luc Bergé We study terahertz (THz) emission by two-color femtosecond filaments in air using pump wavelengths λ 0 from 0.8 to 10.6 μ m . Comprehensive three-dimensional numerical simulations show that tens-of-centimeter long filaments created by a 10.6- μ m pump pulse can produce mJ energy yields and GV/m field str... [Phys. Rev. A 97, 063839] Published Mon Jun 18, 2018
    Keywords: Quantum optics, physics of lasers, nonlinear optics, classical optics
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
    Published by American Physical Society (APS)
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  • 16
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    Exploring six modes of an optical parametric oscillator (2018)
    American Physical Society (APS)
    Details
    Publication Date: 2018-08-14
    Description: Author(s): Luis F. Muñoz-Martínez, Felippe Alexandre Silva Barbosa, Antônio Sales Coelho, Luis Ortiz-Gutiérrez, Marcelo Martinelli, Paulo Nussenzveig, and Alessandro S. Villar Researchers have entangled six modes of a laser cavity—a record number for such a device. [Phys. Rev. A 98, 023823] Published Mon Aug 13, 2018
    Keywords: Quantum optics, physics of lasers, nonlinear optics, classical optics
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
    Published by American Physical Society (APS)
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  • 17
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    Chemical genetics of Plasmodium falciparum (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-05-21
    Description: Malaria caused by Plasmodium falciparum is a disease that is responsible for 880,000 deaths per year worldwide. Vaccine development has proved difficult and resistance has emerged for most antimalarial drugs. To discover new antimalarial chemotypes, we have used a phenotypic forward chemical genetic approach to assay 309,474 chemicals. Here we disclose structures and biological activity of the entire library-many of which showed potent in vitro activity against drug-resistant P. falciparum strains-and detailed profiling of 172 representative candidates. A reverse chemical genetic study identified 19 new inhibitors of 4 validated drug targets and 15 novel binders among 61 malarial proteins. Phylochemogenetic profiling in several organisms revealed similarities between Toxoplasma gondii and mammalian cell lines and dissimilarities between P. falciparum and related protozoans. One exemplar compound displayed efficacy in a murine model. Our findings provide the scientific community with new starting points for malaria drug discovery.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874979/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874979/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guiguemde, W Armand -- Shelat, Anang A -- Bouck, David -- Duffy, Sandra -- Crowther, Gregory J -- Davis, Paul H -- Smithson, David C -- Connelly, Michele -- Clark, Julie -- Zhu, Fangyi -- Jimenez-Diaz, Maria B -- Martinez, Maria S -- Wilson, Emily B -- Tripathi, Abhai K -- Gut, Jiri -- Sharlow, Elizabeth R -- Bathurst, Ian -- El Mazouni, Farah -- Fowble, Joseph W -- Forquer, Isaac -- McGinley, Paula L -- Castro, Steve -- Angulo-Barturen, Inigo -- Ferrer, Santiago -- Rosenthal, Philip J -- Derisi, Joseph L -- Sullivan, David J -- Lazo, John S -- Roos, David S -- Riscoe, Michael K -- Phillips, Margaret A -- Rathod, Pradipsinh K -- Van Voorhis, Wesley C -- Avery, Vicky M -- Guy, R Kiplin -- AI045774/AI/NIAID NIH HHS/ -- AI053680/AI/NIAID NIH HHS/ -- AI067921/AI/NIAID NIH HHS/ -- AI075517/AI/NIAID NIH HHS/ -- AI075594/AI/NIAID NIH HHS/ -- AI080625/AI/NIAID NIH HHS/ -- AI082617/AI/NIAID NIH HHS/ -- AI28724/AI/NIAID NIH HHS/ -- AI35707/AI/NIAID NIH HHS/ -- AI53862/AI/NIAID NIH HHS/ -- AI772682/AI/NIAID NIH HHS/ -- CA78039/CA/NCI NIH HHS/ -- F32 AI077268/AI/NIAID NIH HHS/ -- F32 AI077268-03/AI/NIAID NIH HHS/ -- P01 AI035707/AI/NIAID NIH HHS/ -- P01 AI035707-140007/AI/NIAID NIH HHS/ -- P01 CA078039-10/CA/NCI NIH HHS/ -- P41 RR001614/RR/NCRR NIH HHS/ -- P41 RR001614-246970/RR/NCRR NIH HHS/ -- R01 AI045774/AI/NIAID NIH HHS/ -- R01 AI045774-09/AI/NIAID NIH HHS/ -- R37 AI028724/AI/NIAID NIH HHS/ -- R37 AI028724-17/AI/NIAID NIH HHS/ -- R56 AI082617/AI/NIAID NIH HHS/ -- R56 AI082617-01/AI/NIAID NIH HHS/ -- U01 AI053862/AI/NIAID NIH HHS/ -- U01 AI053862-05/AI/NIAID NIH HHS/ -- U01 AI075594-03/AI/NIAID NIH HHS/ -- UL1 TR000005/TR/NCATS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2010 May 20;465(7296):311-5. doi: 10.1038/nature09099.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20485428" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antimalarials/*analysis/isolation & purification/*pharmacology ; Cell Line ; *Drug Discovery ; Drug Evaluation, Preclinical ; Drug Resistance/drug effects ; Drug Therapy, Combination ; Erythrocytes/drug effects/parasitology ; Humans ; Malaria, Falciparum/drug therapy/parasitology ; Mice ; Phenotype ; Phylogeny ; Plasmodium falciparum/*drug effects/*genetics/metabolism ; Reproducibility of Results ; Small Molecule Libraries/chemistry/pharmacology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 18
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    Asymmetric segregation of polarized antigen on B cell division shapes presentation capacity (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-01-28
    Description: During the activation of humoral immune responses, B cells acquire antigen for subsequent presentation to cognate T cells. Here we show that after mouse B cells accumulate antigen, it is maintained in a polarized distribution for extended periods in vivo. Using high-throughput imaging flow cytometry, we observed that this polarization is preserved during B cell division, promoting asymmetric antigen segregation among progeny. Antigen inheritance correlates with the ability of progeny to activate T cells: Daughter cells receiving larger antigen stores exhibit a prolonged capacity to present antigen, which renders them more effective in competing for T cell help. The generation of progeny with differential capacities for antigen presentation may have implications for somatic hypermutation and class switching during affinity maturation and as B cells commit to effector cell fates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thaunat, Olivier -- Granja, Aitor G -- Barral, Patricia -- Filby, Andrew -- Montaner, Beatriz -- Collinson, Lucy -- Martinez-Martin, Nuria -- Harwood, Naomi E -- Bruckbauer, Andreas -- Batista, Facundo D -- Cancer Research UK/United Kingdom -- New York, N.Y. -- Science. 2012 Jan 27;335(6067):475-9. doi: 10.1126/science.1214100.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lymphocyte Interaction Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22282815" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antigen Presentation ; Antigens/*analysis/*immunology ; B-Lymphocytes/cytology/*immunology ; Cell Division ; Cell Proliferation ; Cells, Cultured ; Coculture Techniques ; Computer Simulation ; Flow Cytometry ; *Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Models, Immunological ; Muramidase/analysis/immunology ; T-Lymphocytes/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 19
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    Maxwell-consistent, symmetry- and energy-preserving solutions for ultrashort-laser-pulse propagation beyond the paraxial approximation (2018)
    American Physical Society (APS)
    Details
    Publication Date: 2018-10-30
    Description: Author(s): P. González de Alaiza Martínez, G. Duchateau, B. Chimier, R. Nuter, I. Thiele, S. Skupin, and V. T. Tikhonchuk We analytically and numerically investigate the propagation of ultrashort tightly focused laser pulses in vacuum, with particular emphasis on Hermite-Gaussian and Laguerre-Gaussian modes. We revisit the Lax series approach for forward-propagating linearly polarized laser pulses, to obtain Maxwell-co... [Phys. Rev. A 98, 043849] Published Mon Oct 29, 2018
    Keywords: Quantum optics, physics of lasers, nonlinear optics, classical optics
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
    Published by American Physical Society (APS)
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  • 20
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    Parametric resonances in a temporal photonic crystal slab (2018)
    American Physical Society (APS)
    Details
    Publication Date: 2018-11-29
    Description: Author(s): Juan Sabino Martínez-Romero and P. Halevi We have studied resonances in a dynamic slab whose permittivity and/or permeability are periodic functions of time, namely, a temporal photonic crystal. We find strong and narrow resonances for frequencies that are equal to 1 / 2 or 3 / 2 , etc. of the modulation frequency provided that a certain geometr... [Phys. Rev. A 98, 053852] Published Wed Nov 28, 2018
    Keywords: Quantum optics, physics of lasers, nonlinear optics, classical optics
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
    Published by American Physical Society (APS)
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