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  • Wiley  (60)
  • American Society of Hematology  (51)
  • 2015-2019  (48)
  • 2010-2014  (63)
  • 1
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    Analysis of CLA Isomer Distribution in Nutritional Supplements by Single Column Silver-Ion HPLC (2012)
    Wiley
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    Publication Date: 2012-11-24
    Print ISSN: 0003-021X
    Electronic ISSN: 1558-9331
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Wiley
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  • 2
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    22‐KYR‐LONG RECORD OF SURFACE FAULTING ALONG THE SOURCE OF THE 30 OCTOBER 2016 EARTHQUAKE (CENTRAL APENNINES, ITALY), FROM INTEGRATED PALEOSEISMIC DATASETS (2019)
    Wiley
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    Publication Date: 2019
    Description: Abstract We integrate paleoseismic datasets along the Mt. Vettore‐Mt. Bove normal fault‐system (VBFS) rupturing at surface in the 30 October 2016 Norcia earthquake. Through the analysis of new trenches from this work and a review of the pre‐existing data, we correlate events among trench sites along antithetic and synthetic fault splays. We recognize seven M6.5, 2016 Norcia‐type (or larger) surface‐faulting events in the last ~22 kyr, including 2016. Before 2016, one event occurred in the past two millennia (260‐575 CE), and possibly corresponds to the event damaging Rome in 443 CE or 484/508 CE. Three previous events occurred between 10590 BCE and 415 BCE, whereas the two oldest ones date between 19820 BCE and 16540 BCE. The average recurrence time is 3360–3640 yrs for the last ~22 kyr, and 1220‐1970 yrs for the last ~4 kyr. We infer a minimum dip‐slip rate of 0.26‐0.38 mm/yr on the master fault in the central portion of the VBFS, and a dip‐slip rate of at least 0.10 mm/yr on the southernmost portion. We infer a Middle‐Late Pleistocene inception of the long‐term scarp of the investigated splays. The along‐strike variation of slip rates well reproduces the trend of the 2016 surface slip, thus the time window exposed in the trenches is representative for the present fault activity. Based on trenching data, different earthquake rupture scenarios should be also considered for local hazard assessment.
    Print ISSN: 2169-9313
    Electronic ISSN: 2169-9356
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 3
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    Nitric Oxide Chemical Donor Affects the Early Phases of In Vitro Wound Healing Process (2016)
    Wiley
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    Publication Date: 2016-02-04
    Description: An artificial wound in a confluent monolayer of human keratinocyte HaCaT cells or mouse embryo fibroblast Swiss NIH 3T3 cells was used to analyze the effects of the nitric oxide (NO) chemical donor, S-nitroso-N-acetylpenicillamine (SNAP). SNAP exposure promoted an enhanced rate of wound closure and accelerated motility of both keratinocytes and fibroblasts compared to control cells. The wounded monolayer cultures of HaCaT and NIH 3T3 cells, treated with or without SNAP, were monitored under a phase contrast microscope. Structural and ultrastructural modifications were analysed by scanning electron microscopy (SEM). The images were captured by a digital camera at different time points (0-28 h) and the wound area was analysed through software included in Matlab®. As early as 15 minutes, SNAP induced significant cytoskeletal remodelling, as shown by immunostaining (phalloidin-labelling), which in turn was associated with increased filopodium number and length rise. NO donor treatment also induced overexpression of Ki-67 protein, a typical marker of cell proliferation, as shown by immunostaining. Both SNAP-induced migration and proliferation were antagonized by the NO-sensitive GC inhibitor 1H-[1,2,4]oxadiazolo[-4,3-a]quinoxalin-1-one (ODQ), which suggests activation of the NO/cGMP signalling cascade in the observed SNAP-induced effects in the early stages of the healing process. Moreover, we provide evidence that PPAR-beta antagonist (GSK0660) may interfere with NO-mediated wound healing process. This article is protected by copyright. All rights reserved
    Electronic ISSN: 1097-4652
    Topics: Biology , Medicine
    Published by Wiley
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  • 4
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    Pharmacological inhibition of HSP90 and ras activity as a new strategy in the treatment of HNSCC (2012)
    Wiley
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    Publication Date: 2012-05-08
    Description: Advanced head and neck squamous cell cancer (HNSCC) is currently treated with taxane-based chemotherapy. We have previously shown that docetaxel (DTX) induces a ras-dependent survival signal that can be antagonized by farnesyl transferase inhibitors (FTI) such as tipifarnib (TIP). Here we show that the synergistic TIP/DTX combination determines synergistic apoptotic conditions but, at the same time, it modulates the expression of the components of the multichaperone complex that is, in turn, involved in the regulation of the stability of members of the ras-mediated pathway. Therefore, we have stably transfected HNSCC KB and Hep-2 cells with a plasmid encoding for HSP90. The expression of the protein was increased in both transfected cell lines but its activation status was increased in Hep-2 clones and decreased in KB clones. On the basis of these results, we have treated both parental and HSP90-transfected cells with a HSP90 inhibitor geldanamycin (GA). We have found that the antiproliferative activity of GA is dependent upon the activation status of HSP90 and that it is strongly synergistic when added in combination with TIP but not with DTX in cells overexpressing HSP90 and even more in cells with increased HSP90 activity. These data were paralleled by the decreased expression and activity of the components belonging to the ras→mediated signal transduction pathway. The present results suggest that multichaperone complex activation could be a resistance mechanism to the anti-proliferative and apoptotic effects induced by TIP and that the combination of FTIs such as TIP with GA could be a suitable therapeutic strategy in the treatment of HSP90-overexpressing HNSCC. J. Cell. Physiol. © 2012 Wiley Periodicals, Inc.
    Electronic ISSN: 1097-4652
    Topics: Biology , Medicine
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  • 5
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    Industrial Symbiosis (2012)
    Wiley
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    Publication Date: 2012-02-24
    Print ISSN: 1088-1980
    Electronic ISSN: 1530-9290
    Topics: Energy, Environment Protection, Nuclear Power Engineering
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  • 6
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    A retrospective comparative forecast test on the 1992 Landers sequence (2011)
    Wiley
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    Publication Date: 2011-05-26
    Description: We perform a retrospective forecast experiment on the 1992 Landers sequence comparing the predictive power of commonly used model frameworks for short-term earthquake forecasting. We compare a modified short-term earthquake probability (STEP) model, six realizations of the epidemic-type aftershock sequence (ETAS) model, and four models that combine Coulomb stress changes calculations and rate-and-state theory to generate seismicity rates (CRS models). We perform the experiment under the premise of a controlled environment with predefined conditions for the testing region and data for all modelers. We evaluate the forecasts with likelihood tests to analyze spatial consistency and the total amount of forecasted events versus observed data. We find that (1) 9 of the 11 models perform superior compared to a simple reference model, (2) ETAS models forecast the spatial evolution of seismicity best and perform best in the entire test suite, (3) the modified STEP model matches best the total number of events, (4) CRS models can only compete with empirical statistical models by introducing stochasticity in these models considering uncertainties in the finite-fault source model, and (5) resolving Coulomb stress changes on 3-D optimally oriented planes is more adequate for forecasting purposes than using the specified receiver fault concept. We conclude that statistical models perform generally better than the tested physics-based models and parameter value updates using the occurrence of aftershocks generally improve the predictive power in particular for the purely statistical models in space and time.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 7
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    Redefining Industrial Symbiosis (2012)
    Wiley
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    Publication Date: 2012-02-16
    Description: The most commonly cited definition of industrial symbiosis (IS), by Chertow (2000) , has served well to foster discussion and research for more than a decade. The definition reflected the state of research and practice at the time; as both have advanced, some terms have been interpreted in substantially different ways. In this article we analyze those generally used terms for their connection to the ecological metaphor that is the root of industrial ecology, and their varied interpretations in IS research and practice over time. We then propose an updated definition intended to communicate the essence of IS as a tool for innovative green growth: IS engages diverse organizations in a network to foster eco-innovation and long-term culture change. Creating and sharing knowledge through the network yields mutually profitable transactions for novel sourcing of required inputs and value-added destinations for non-product outputs, as well as improved business and technical processes. We posit that, although geographic proximity is often associated with IS, it is neither necessary nor sufficient—nor is a singular focus on physical resource exchange.
    Print ISSN: 1088-1980
    Electronic ISSN: 1530-9290
    Topics: Energy, Environment Protection, Nuclear Power Engineering
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  • 8
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    Industrial Symbiosis in European Policy (2012)
    Wiley
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    Publication Date: 2012-02-22
    Print ISSN: 1088-1980
    Electronic ISSN: 1530-9290
    Topics: Energy, Environment Protection, Nuclear Power Engineering
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  • 9
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    Heterogeneities along the 2009 L'Aquila normal fault inferred by the b-value distribution (2012)
    Wiley
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    Publication Date: 2012-08-04
    Description: In this study we map the distribution of the b-value of the Gutenberg-Richter law—as well as complementary seismicity parameters—along the fault responsible for the 2009 MW 6.1 L'Aquila earthquake. We perform the calculations for two independent aftershock sub-catalogs, before and after a stable magnitude of completeness is reached. We find a substantial spatial variability of the b-values, which range from 0.6 to 1.3 over the fault plane. The comparison between the spatial distribution of the b-values and the main-shock slip pattern shows that the largest slip occurs in normal-to-high b-values portion of the fault plane, while low b-value is observed close to the main-shock nucleation. No substantial differences are found in the b-value computed before and after the main-shock struck in the small region of the fault plane populated by foreshocks.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 10
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    The Electromagnetic Field for a PEC Wedge over a Grounded Dielectric Slab: Part I - Formulation and Validation (2017)
    Wiley
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    Publication Date: 2017-10-28
    Description: Complex scattering problems are often made by composite structures where wedges and penetrable substrates may interact at near field. In this paper (Part I) together with its companion paper (Part II) we study the canonical problem constituted of a Perfectly Electrically Conducting (PEC) wedge lying on a grounded dielectric slab with a comprehensive mathematical model based on the application of the Generalized Wiener-Hopf Technique (GWHT) with the help of equivalent circuital representations for linear homogenous regions (angular and layered region). The proposed procedure is valid for the general case and the papers focus on E-polarization. The solution is obtained using analytical and semi-analytical approaches that reduce the Wiener-Hopf factorization to integral equations. Several numerical test cases validate the proposed method. The scope of Part I is to present the method and its validation applied to the problem. The companion paper Part II focuses on the properties of the solution and it presents physical and engineering insights as GTD/UTD diffraction coefficients, total far fields, modal fields and excitation of surface and leaky waves for different kinds of source. The structure is of interest in antenna technologies and electromagnetic compatibility (tip on a substrate with guiding and antenna properties).
    Print ISSN: 0048-6604
    Electronic ISSN: 1944-799X
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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