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  • 2020-2024  (4,880)
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  • 1
    Keywords: Pharmacology. ; Cardiology. ; Neurosciences. ; Clinical biochemistry. ; Pharmacology. ; Cardiology. ; Neuroscience. ; Medical Biochemistry.
    Description / Table of Contents: Part I: ROS Revisited: Changing the Focus from Oxidative Stress and Redox Biology to Redox Medicine -- Demystifying oxidative stress -- Oxidants in Physiological Processes -- Network Medicine-Based Unbiased Disease Modules for Drug and Diagnostic Target Identification in ROSopathies -- Part II Targeting antioxidant responses -- Development of Telintra as an Inhibitor of Glutathione S-Transferase P -- Perspectives on the Clinical Development of NRF2-Targeting Drugs -- Part III: Inhibiting ROS formation and toxification -- NOX Inhibitors: From Bench to Naxibs to Bedside -- Nitric Oxide Synthase Inhibitors into the Clinic at Last -- Xanthine Oxidoreductase Inhibitors -- Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches -- Inhibition of Myeloperoxidase -- Part IV: Stimulating/substituting ROS -- Effects of Mammalian Thioredoxin Reductase Inhibitors -- Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation -- Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers -- Part V: Repairing ROS damage -- Soluble Guanylate Cyclase Stimulators and Activators – Peter Sander -- Inhibitors of Advanced Glycation End Product (AGE) Formation and Accumulation.
    Abstract: Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 425 p. 70 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030685102
    Series Statement: Handbook of Experimental Pharmacology, 264
    DDC: 615
    Language: English
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  • 2
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neuropharmacology. ; Psychiatry. ; Neurology . ; Neuropharmacology. ; Psychiatry. ; Neurology.
    Description / Table of Contents: Dosing psychedelics and MDMA -- Psychedelic Group Therapy -- Set and Setting: Aesthetic experiences and their contribution to psychedelic therapies -- Psychedelic-Assisted Therapy for Social Adaptability in Autistic Adults -- Foundations for Training Psychedelic Therapists -- Ayahuasca for the Treatment of Depression -- Psilocybin for the Treatment of Depression -- Ketamine for the Treatment of Depression -- The Potential of Psychedelics for End of Life and Palliative Care -- Psychedelic-Assisted Therapy for Addiction and Potential Mechanisms of Action -- Psilocybin for Tobacco Use Disorder -- Psychedelic Drugs as Anti-Inflammatory Agents -- Psilocybin for the Treatment of Obsessive-Compulsive Disorder -- Psilocybin for the Treatment of Headache and Pain Disorders -- Psilocybin for the Treatment of Neurodegenerative Disorders -- Psilocybin for Trauma-Related Disorders.
    Abstract: Psychedelic therapies are gaining traction as potential treatments for a wide range of indications, but the structure and delivery of psychedelic therapies are a sharp departure from more traditional models of psychotherapy and pharmacotherapy for psychiatric and other medical disorders. This may be critical to their success. The current volume provides a comprehensive review of the state of the science of psychedelic therapies, including discussion of models and approaches to psychedelic therapies as well as the current status of safety and efficacy data for mood, substance use, trauma, obsessive-compulsive, neurodevelopmental, neurodegenerative disorders, neurological, and inflammatory disorders.
    Type of Medium: Online Resource
    Pages: VIII, 332 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031121845
    Series Statement: Current Topics in Behavioral Neurosciences, 56
    DDC: 615.78
    Language: English
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  • 3
    Keywords: Neurosciences. ; Cognitive neuroscience. ; Psychobiology. ; Human behavior. ; Sociology. ; Neuroscience. ; Cognitive Neuroscience. ; Behavioral Neuroscience. ; Sociology.
    Description / Table of Contents: Molecular imaging of the human emotion circuit -- The neurocognitive mechanisms of unconscious emotional responses -- Social and Affective Neuroscience of Embodiment -- The neuroscience of beauty -- Mirror Neurons … in action: ERPs and neuroimaging evidence -- Sex differences in social cognition -- Development of morality and emotional processing -- Trust in Social Interaction: From Dyads to Civilizations -- The time has come to be mindwanderful: Mind wandering and the intuitive psychology mode -- Social Cognition development and socio affective dysfunction in childhood and adolescence -- Clinical neuroscience meets second-person neuropsychiatry -- EEG and ERPs in the study of Language and Social Knowledge -- fMRI and fNIRS methods for social brain studies: hyperscanning possibilities -- Modulating the Social and Affective Brain with transcranial stimulation techniques -- What our eyes can tell us about our social and affective brain? -- Facial EMG – Investigating the interplay of facial muscles and emotions.
    Abstract: This Open Access book presents the current state of the art knowledge on social and affective neuroscience based on empirical findings. This volume is divided into several sections first guiding the reader through important theoretical topics within affective neuroscience, social neuroscience and moral emotions, and clinical neuroscience. Each chapter addresses everyday social interactions and various aspects of social interactions from a different angle taking the reader on a diverse journey. The last section of the book is of methodological nature. Basic information is presented for the reader to learn about common methodologies used in neuroscience alongside advanced input to deepen the understanding and usability of these methods in social and affective neuroscience for more experienced readers.
    Type of Medium: Online Resource
    Pages: XXXIII, 302 p. 55 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031086519
    DDC: 612.8
    Language: English
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  • 4
    Keywords: Biotic communities. ; Freshwater ecology. ; Marine ecology. ; Ecosystems. ; Freshwater and Marine Ecology.
    Description / Table of Contents: Part (I) Introduction to river hazards and their management: Chapter 1. Natural River Hazards: Their Impacts and Mitigation Techniques -- Chapter 2. Assessment of sediment hazard and associated measurement -- Chapter 3. Modelling approach to study the riverine flood hazard of lower Damodar river -- Chapter 4. Field measurement of accumulated surface water and infiltration depth in a flood-prone Langol catchment of Manipur valley region -- Chapter 5. Soil erosion analysis with respect to land use / land cover change in Godavari basin -- Part (II) Stability of Hydraulic Structures and Sediment Transport: Chapter 6. Stability of hydraulic structures against erosion and scour due to water jets -- Chapter 7. Stabilization of Manmade Embankments at Indian Sundarban Estuary through Turbulence Control at Flow-Sediment Interface: Field Survey and Flume Experimentation -- Chapter 8. A Review of Sedimentation on Different Types of Weirs -- Chapter 9. A Review on Parametric Studies of Piano Key Weir -- Chapter 10 Influence of boundary condition on the modified 2D shallow water model near the flow-structure interaction zone: a case study in Brahmaputra River -- Chapter 11. A Review on Estimation Methods of Scour Depth around Bridge Pier -- Chapter 12. Estimation of Shear force Distribution in Two-stage open channel using SVM and ANFIS -- Chapter 13. Sediment transport modelling through machine learning methods: Review of current challenges and strategies -- Chapter 14. Impact of Anthropocene on the fluvial sediment supply: The Mahanadi River basin perspective -- Chapter 15. Assessment of sediment hazards by bed level variations around the bridge pier -- Chapter 16. Equation development for equilibrium bed load -- Part (III) Hydrological hazards and ecological restoration: Chapter 17. Flood mitigation with river restoration using Porcupine systems -- Chapter 18. Flood prioritisation of basins based on geomorphometric properties using Morphometric analysis and Principal component analysis: A case study of the Maner River basin -- Chapter 19. Flood modelling of Krishna river at Sangli using HEC-RAS -- Chapter 20. Development of Machine Learning based Flood Prediction Model for Godavari River Basin -- Chapter 21. Field study on soil organic matter content in inundation areas of Langol catchment by loss- on-ignition” method -- Chapter 22. Agricultural Drought Assessment using Satellite based Surface Soil Moisture Estimate -- Chapter 23. A Review on Hydrodynamics of Vegetated Streams -- Chapter 24. Analysis of Stormwater Drainage Network of the Central Zone in the Surat City by Using SWMM 5.1 Software -- Chapter 25. Review of state-of-the-art research on river hydrological hazards, restoration and management -- Chapter 26. Erosion Susceptibility Mapping based on Hypsometric Analysis using Remote Sensing and Geographical Information System Techniques -- Part (IV) Climate change and Global warming issues: Chapter 27. Climate Change Implication and Adaptation for River systems -- Chapter 28. Non-parametric approaches to identify rainfall pattern in semi-arid regions: Ranipet, Vellore, and Tirupathur districts, Tamil Nadu, India -- Chapter 29. Decadal-based analysis of hydrological components in the Kesinga sub-catchment in Mahanadi Basin: An assessment of climate variability impact -- Chapter 30. Prediction of Future Rainfall in the Upper Godavari Basin Using Statistical Downscaling Model -- Chapter 31. Projecting Future Maximum Temperature Changes in River Ganges Basin using Observations and Statistical Downscaling Model (SDSM) -- Chapter 32. Trend Assessment of Rainfall over Mumbai and Pune Cities -- Chapter 33. Evaluation of Potential lakes Susceptible to GLOF using Multi-Criteria Assessment in Jhelum Sub-basin of Indus Basin.
    Abstract: This edited book covers all aspects of River related disasters, challenges, and opportunities. Step-by-step descriptions are provided of river dynamics and associated hazards, and their applications in hazard assessments, accompanied by several experimental, filed and numerical studies. In addition, a systematic table of content is given to aid in identifying River hazards challenges and opportunities. Essential information is provided on River dynamics, hydrological processes and climate change issues, and an individual chapter is devoted to ecological restoration and river hazard management. Further topics include the stability of hydraulic structures, sediment transport, and debris flow in the hilly streams. This book will provide students, researchers, scientists, water resources managers with a comprehensive overview of the River dynamics and flood hazards in various sectors of water-related disasters and will enable them to explore the scope of application of the computational techniques and will enable them to explore the scope of River related disasters, allied branches and their field-specific problems. Professionals and policymakers may also explore the implementation of these approaches in their workplace to tackle complex river dynamics and hydrological phenomena occurring in their study area.
    Type of Medium: Online Resource
    Pages: X, 624 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811971006
    Series Statement: Disaster Resilience and Green Growth,
    DDC: 577
    Language: English
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  • 5
    Keywords: Biotic communities. ; Biodiversity. ; Freshwater ecology. ; Marine ecology. ; Climatology. ; Physical geography. ; Botanical chemistry. ; Ecosystems. ; Biodiversity. ; Freshwater and Marine Ecology. ; Climate Sciences. ; Physical Geography. ; Plant Biochemistry.
    Description / Table of Contents: Preface -- The marine physical environment during the Polar Night -- Light in the Polar Night -- Marine micro- and macroalgae in the Polar Night -- Zooplankton in the Polar Night -- Benthic communities in the Polar Night -- Fish ecology in the Polar Night -- Biological clocks and rhythms in polar organisms -- Sensor carrying platforms -- Operative habitat mapping and monitoring in the Polar Night -- The Polar Night exhibition: Life and light at the dead of night -- Index.
    Abstract: Until recently, the prevailing view of marine life at high latitudes has been that organisms enter a general resting state during the dark Polar Night and that the system only awakens with the return of the sun. Recent research, however, with coordinated, multidisciplinary field campaigns based on the high Arctic Archipelago of Svalbard, have provided a radical new perspective. Instead of a system in dormancy, a new perspective of a system in full operation and with high levels of activity across all major phyla is emerging. Examples of such activities and processes include: Active marine organisms at sea surface, water column and the sea-floor. At surface we find active foraging in seabirds and fish, in the water column we find a high biodiversity and activity of zooplankton and larvae such as active light induced synchronized diurnal vertical migration, and at seafloor there is a high biodiversity in benthic animals and macroalgae. The Polar Night is a period for reproduction in many benthic and pelagic taxa, mass occurrence of ghost shrimps (Caprellides), high abundance of Ctenophores, physiological evidence of micro- and macroalgal cells that are ready to utilize the first rays of light when they appear, deep water fishes found at water surface in the Polar night, and continuous growth of bivalves throughout the winter. These findings not only begin to shape a new paradigm for marine winter ecology in the high Arctic, but also provide conclusive evidence for a top-down controlled system in which primary production levels are close to zero. In an era of environmental change that is accelerated at high latitudes, we believe that this new insight is likely to strongly impact how the scientific community views the high latitude marine ecosystem. Despite the overwhelming darkness, the main environmental variable affecting marine organisms in the Polar Night is in fact light. The light regime during the Polar Night is unique with respect to light intensity, spectral composition of light and photoperiod. .
    Type of Medium: Online Resource
    Pages: XI, 375 p. 133 illus., 116 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030332082
    Series Statement: Advances in Polar Ecology, 4
    DDC: 577
    Language: English
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  • 6
    Keywords: Biotic communities. ; Forestry. ; Physical geography. ; Applied ecology. ; Ecology . ; Ecosystems. ; Forestry. ; Earth System Sciences. ; Applied Ecology. ; Terrestial Ecology.
    Description / Table of Contents: Chapter 1. Introduction to Fire Ecology across USA Forested Ecosystems: Past, Present, and Future (Cathryn H. Greenberg, Beverly S. Collins, Scott Goodrick, Michael C. Stambaugh, and Gary R. Wein) -- Chapter 2. The Role of Fire in the Dynamics of Piedmont Vegetation (Joanna Spooner, Robert K. Peet, Michael P. Schafale, Alan S. Weakley and Thomas R. Wentworth) -- Chapter 3. Fire Ecology and Fire Management of Southeastern Coastal Plain Pine Ecosystems (Jeff S. Glitzenstein, J. Stephen Brewer, Ronald. E. Masters, J. Morgan Varner, and J. Kevin Hiers) -- Chapter 4. Fire Ecology and Management in Eastern Broadleaf and Appalachian Forests (Mary A. Arthur, J. Morgan Varner, Charles W. Lafon, Heather D. Alexander, Daniel C. Dey, Craig A. Harper, Sally P. Horn, Todd F. Hutchinson, Tara L. Keyser, Marcus A. Lashley, Christopher E. Moorman, and Callie J. Schweitzer) -- Chapter 5. Fire Ecology and Management of Forest Ecosystems in the Western Central Hardwoods and Prairie-Forest Border (Michael C. Stambaugh, Benjamin O. Knapp, and Daniel C. Dey) -- Chapter 6. Fire in Floodplain Forests of the Southeastern USA hy (Paul R. Gagnon, Loretta L. Battaglia, Brice B. Hanberry, William H. Conner, and Sammy L. King) -- Chapter 7. History and Future of Fire in Hardwood and Conifer Forests of the Great Lakes-Northeastern Forest Region, USA(Lee E. Frelich, Craig G. Lorimer, and Michael C. Stambaugh) -- Chapter 8. Fire Ecology of Rocky Mountain Forests(Sharon M. Hood, Brian J. Harvey, Paula J. Fornwalt, Cameron E. Naficy, Winslow D. Hansen, Kimberley T. Davis, Mike A. Battaglia, Camille Stevens-Rumann, Victoria Saab) -- Chapter 9. Fire Ecology of the North American Mediterranean-Climate Zone(Hugh D. Safford, Ramona J. Butz, Gabrielle N. Bohlman, Michelle Coppoletta, Becky L. Estes, Shana E. Gross, Kyle E. Merriam, Marc D. Meyer, Nicole A. Molinari, and Amarina Wuenschel) -- Chapter 10. Fire Ecology and Management in Pacific Northwest Forests(Matthew J. Reilly, Jessica E. Halofsky, Meg A. Krawchuk, Daniel C. Donato, Paul F. Hessburg, James Johnston, Andrew Merschel, Mark E. Swanson, Joshua S. Halofsky, and Thomas A. Spies) -- Chapter 11. Fire Ecology and Management of Southwestern Forests(Peter Z. Fulé, Catrin M. Edgeley, Carol L. Chambers, Serra Hoagland, Blanca Céspedes) -- Chapter 12. Fire and Forests in the 21st Century: Managing Resilience under Changing Climates and Fire Regimes in USA Forests(James M. Vose, David L. Peterson, Christopher J. Fettig, Jessica E. Halofsky, J. Kevin Hiers, Robert E. Keane, Rachel Loehman, and Michael C. Stambaugh).
    Abstract: This edited volume presents original scientific research and knowledge synthesis covering the past, present, and potential future fire ecology of major US forest types, with implications for forest management in a changing climate. The editors and authors highlight broad patterns among ecoregions and forest types, as well as detailed information for individual ecoregions, for fire frequencies and severities, fire effects on tree mortality and regeneration, and levels of fire-dependency by plant and animal communities. The foreword addresses emerging ecological and fire management challenges for forests, in relation to sustainable development goals as highlighted in recent government reports. An introductory chapter highlights patterns of variation in frequencies, severities, scales, and spatial patterns of fire across ecoregions and among forested ecosystems across the US in relation to climate, fuels, topography and soils, ignition sources (lightning or anthropogenic), and vegetation. Separate chapters by respected experts delve into the fire ecology of major forest types within US ecoregions, with a focus on the level of plant and animal fire-dependency, and the role of fire in maintaining forest composition and structure. The regional chapters also include discussion of historic natural (lightning-ignited) and anthropogenic (Native American; settlers) fire regimes, current fire regimes as influenced by recent decades of fire suppression and land use history, and fire management in relation to ecosystem integrity and restoration, wildfire threat, and climate change. The summary chapter combines the major points of each chapter, in a synthesis of US-wide fire ecology and forest management into the future. This book provides current, organized, readily accessible information for the conservation community, land managers, scientists, students and educators, and others interested in how fire behaviour and effects on structure and composition differ among ecoregions and forest types, and what that means for forest management today and in the future. .
    Type of Medium: Online Resource
    Pages: XVII, 502 p. 71 illus., 65 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030732677
    Series Statement: Managing Forest Ecosystems, 39
    DDC: 577
    Language: English
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  • 7
    Keywords: Medical sciences. ; Statistics . ; Health Sciences. ; Applied Statistics.
    Description / Table of Contents: Preface -- Chapter 1: Regression Analysis -- Chapter 2: Cox Regressions -- Chapter 3: Accelerated Failure Time Models -- Chapter 4: Simple Dataset with Event as Outcome and Treatment as Predictor -- Chapter 5: Simple Dataset with Death as Outcome and Treatment Modality, Cholesterol, and Age as Predictors -- Chapter 6: Glioma Brain Cancer -- Chapter 7: Linoleic Acid for Colonic Carcinoma -- Chapter 8: The Effect on Survival of Maintained Chemotherapy with Acute Myelogenous Leucemia -- Chapter 9: Eighty Four Month Parallel Group Mortality Study -- Chapter 10: The Effect on Survival from Stages 1 and 2 Histiocytic Lymphoma -- Chapter 11: Survival of 64 Lymphoma Patients with or without B Symptoms -- Chapter 12: Effect on Time-to-Event of Group Membership -- Chapter 13: The Effect on Survival of Group Membership -- Chapter 14: Deaths from Carcinoma after Exposure to Carcinogens in Rats -- Chapter 15: Effect of Group Membership on Survival -- Chapter 16: Multiple Variables Regression Study of 2421 Stroke Patients Assessed for Time to Second Stroke -- Chapter 17: Hypothesized 55 Patient Study of Effect of Treatment Modality on Survival -- Chapter 18: One Year Follow-up Study with Many Censored Patients -- Chapter 19: Alcohol Relapse after Detox Program Treated with or without Personal Coach -- Chapter 20: Alcohol Relapse after Detox Program with 3 Predictors -- Chapter 21: Ayurvedic Therapy for Human Immunodeficiency Virus -- Chapter 22: Time to Event other Than Cox -- Chapter 23: Abstracts of the Chapters 1 to 22.
    Abstract: An important novel menu for Survival Analysis entitled Accelerated Failure Time (AFT) models has been published by IBM (international Businesss Machines) in its SPSS statistical software update of 2023. Unlike the traditional Cox regressions that work with hazards, which are the ratio of deaths and non-deaths in a sample, it works with risk of death, which is the proportion of deaths in the same sample. The latter approach may provide better sensitivity of testing, but has been seldom applied, because with computers risks are tricky and hazards because they are odds are fine. This was underscored in 1997 by Keiding and colleague statisticians from Copenhagen University who showed better-sensitive goodness of fit and null-hypothesis tests with AFT than with Cox survival tests. So far, a controlled study of a representative sample of clinical Kaplan Meier assessments, where the sensitivity of Cox regression is systematically tested against that of AFT modeling, has not been accomplished. This edition is the first textbook and tutorial of AFT modeling both for medical and healthcare students and for professionals. Each chapter can be studied as a standalone, and, using, real as well as hypothesized data, it tests the performance of the novel methodology against traditional Cox regressions. Step by step analyses of over 20 data files stored at Supplementary Files at Springer Interlink are included for self-assessment. We should add that the authors are well qualified in their field. Professor Zwinderman is past-president of the International Society of Biostatistics (2012-2015) and Professor Cleophas is past-president of the American College of Angiology (2000-2002). From their expertise they should be able to make adequate selections of modern data analysis methods for the benefit of physicians, students, and investigators. The authors have been working and publishing together for 25 years and their research can be characterized as a continued effort to demonstrate that clinical data analysis is not mathematics but rather a discipline at the interface of biology and mathematics.
    Type of Medium: Online Resource
    Pages: XIV, 224 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031316326
    DDC: 610
    Language: English
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  • 8
    Keywords: Toxicology. ; Pharmacology. ; Environment. ; Toxicology. ; Pharmacology. ; Environmental Sciences.
    Description / Table of Contents: Overview of Nanotoxicology in Humans and the Environment: Developments.-The potential adverse effects of engineered nanomaterial exposure to human health following pulmonary, oral and dermal exposure @font-face {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:3 0 0 0 1 0;}p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:""; margin:0cm; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman",serif; mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-US; mso-fareast-language:ZH-CN;}.MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-size:11.0pt; mso-ansi-font-size:11.0pt; mso-bidi-font-size:11.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri; mso-fareast-theme-font:minor-latin; 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    Abstract: The book covers the area of ‘Nanotoxicology’ but primarily from the point of view of nanotoxicology at the interface with other disciplines including human toxicology; environmental toxicology; characterization, dose and transformations; regulation; public and elite group perceptions; and interactions with innovation.Nanotoxicology in Humans and the Environment is written for researchers in nanotoxicology in academia, industry, government, and research students. Given the rapid development, the maturing of the discipline and its importance in current regulation and industry development (eg REACH, TSCA), the book is very timely.
    Type of Medium: Online Resource
    Pages: V, 259 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030798086
    Series Statement: Molecular and Integrative Toxicology,
    DDC: 615.90072
    Language: English
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  • 9
    Keywords: Clinical medicine Research. ; Statistics . ; Data mining. ; Big data. ; Clinical Research. ; Applied Statistics. ; Data Mining and Knowledge Discovery. ; Big Data.
    Description / Table of Contents: Chapter 1. General Introduction -- Chapter 2. Mathematical Models for Separating Quantiles from One Another -- Part I: Simple Univariate Regressions versus Quantile -- Chapter 3. Traditional and Robust Regressions versus Quantile -- Chapter 4. Autoregressions versus quantile -- Chapter 5. Discrete Trend Analysis versus Quantile -- Chapter 6. Continuous Trend Analysis versus Quantile -- Binary Poisson / Negative Binomial Regression versus Quantile -- Chapter 8. Robust Standard Errors Regressions versus Quantile -- Chapter 9. Optimal Scaling versus Quantile Regression -- Chapter 10. Intercept only Poisson Regression versus Quantile -- Part II: Multiple Variables Regressions versus Quantile -- Chapter 11. Four Predictors Regressions versus Quantile -- Chapter 12. Gene Expressions Regressions, Traditional versus Quantile -- Chapter 13. Koenker's Multiple Variables Regression with Quantile -- Chapter 14. Interaction Adjusted Regression versus Quantile -- Chapter 15. Quantile Regression to Study Corona Deaths -- Chapter 16. Laboratory Values Predict Survival Sepsis, Traditional Regression versus Quantile -- Chapter 17. Multinomial Poisson Regression versus Quantile -- Chapter 18. Regressions with Inconstant Variability versus Quantile -- Chapter 19. Restructuring Categories into Multiple Dummy Variables versus Quantile -- Chapter 20. Poisson Events per Person per Period of Time versus Quantile -- Part III: Special Regressions versus Quantile -- Chapter 21. Two Stage Least Squares Regressions versus Quantile -- Chapter 22. Partial Correlations versus Quantile Regressions -- Chapter 23. Random Intercept Regression versus Quantile -- Chapter 24. Regression Trees versus Quantile -- Chapter 25. Kernel Regression versus Quantile -- Chapter 26. Quasi-likelihood Regression versus Quantile -- Chapter 27. Summaries.
    Abstract: Quantile regression is an approach to data at a loss of homogeneity, for example (1) data with outliers, (2) skewed data like corona - deaths data, (3) data with inconstant variability, (4) big data. In clinical research many examples can be given like circadian phenomena, and diseases where spreading may be dependent on subsets with frailty, low weight, low hygiene, and many forms of lack of healthiness. Stratified analyses is the laborious and rather explorative way of analysis, but quantile analysis is a more fruitful, faster and completer alternative for the purpose. Considering all of this, we are on the verge of a revolution in data analysis. The current edition is the first textbook and tutorial of quantile regressions for medical and healthcare students as well as recollection/update bench, and help desk for professionals. Each chapter can be studied as a standalone and covers one of the many fields in the fast growing world of quantile regressions. Step by step analyses of over 20 data files stored at extras.springer.com are included for self-assessment. We should add that the authors are well qualified in their field. Professor Zwinderman is past-president of the International Society of Biostatistics (2012-2015) and Professor Cleophas is past-president of the American College of Angiology(2000-2002). From their expertise they should be able to make adequate selections of modern quantile regression methods for the benefit of physicians, students, and investigators. .
    Type of Medium: Online Resource
    Pages: XII, 290 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030828400
    DDC: 615.50724
    Language: English
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  • 10
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Veterinary microbiology. ; Microbial populations. ; Agriculture. ; Veterinary Microbiology. ; Microbial Communities. ; Agriculture.
    Description / Table of Contents: Chapter 1: Gastrointestinal Tract Barrier Efficiency: Function And Threats -- Chapter 2: Gut Health In Production Animals: Butyrate And Intestinal Homeostasis - Effects On The Intestinal Microbiota And Epithelial Hypoxia -- Chapter 3: The Role Of Farm Environment And Management In Shaping The Gut Microbiota Of Poultry -- Chapter 4: Enzymes And Gut Health In Monogastric Animals: Effects Beyond Digestibility -- Chapter 5: Gut Microbiome And Poultry Health -- Chapter 6: Influence Of Sow Gut Microbiota On Colostrum And Piglet Performance -- Chapter 7: Porcine Gut Microbiota And Host Interactions During The Transition From The Suckling To Post-Weaning Phase -- Chapter 8: Adaptive Poultry Gut Capacity To Resist Oxidative Stress -- Chapter 9: Gut Microbiota And The Gut-Brain Axis In Neonatal Calves: Implications For Psychobiotic Usage For Stress Regulation -- Chapter 10: The Gut Mycobiome And Animal Health -- Chapter 11: Immunological Mechanisms Of Probiotics In Chickens -- Chapter 12: Role Of Early Life Intestinal Microbiota In Modulating Immunity In Broiler Chickens -- Chapter 13: Managing Intestinal Health In Farm Animals: A Critical View -- Chapter 14: Pre- And Probiotic Effects On Innate Immunity And Metabolism In Cattle And Swine -- Chapter 15: The Unseen Minority: Biogeographical Investigations Of The Ruminant Gastrointestinal Microbiome Highlight The Importance Of Frequently Ignored Anatomical Regions.
    Abstract: This work sheds new light on the interplay between the gut, gut microbiota, and host physiological processes in production animals. The gut microbiome shapes health and susceptibility to disease and has become a leading area of research in the animal sciences. Gut health encompasses a number of physiological and functional features. Nutrient digestion and absorption, host metabolism and energy generation, a stable microbiome, mucus layer development, barrier function, and mucosal immune responses; all of which are required to interact to make an animal perform physiologically and according to its greatest genetic potential. This carefully presented book broadens our vision, approach and results on gut health and the ability to regulate animal production. Understanding the chemistry of microbiomes has broad implications, including providing functional annotations for the microbial genomes, insights into the chemical languages that link microbes to each other and to their host, and translational implications for precision veterinary medicine, environmental health, and sustainable animal agriculture and welfare. Experts working in microbiome research, host immunity, and animal production, veterinarians and researchers in livestock science will understand the great importance of this volume.
    Type of Medium: Online Resource
    Pages: VII, 325 p. 11 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030903039
    Series Statement: The Microbiomes of Humans, Animals, Plants, and the Environment, 4
    DDC: 636.08901
    Language: English
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