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  • 2020-2024  (351)
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  • 1
    Keywords: Pharmaceutical chemistry. ; Pharmacology. ; Clinical biochemistry. ; Pharmaceutics. ; Pharmacology. ; Medical Biochemistry.
    Description / Table of Contents: Route-Specific Challenges in the Delivery of Poorly Water-Soluble Drugs -- Optimizing the Formulation of Poorly Water-Soluble Drugs -- Solid-State Techniques for Improving Solubility -- Mechanical Particle-Size Reduction Techniques -- Co-solvent and Complexation Systems -- Injectable Formulations of Poorly Water-Soluble Drugs -- Lipid-Based Formulations -- Structured Development Approach for Amorphous Systems -- Melt Extrusion -- Spray-Drying Technology -- Pharmaceutical Cryogenic Technologies -- Precipitation Technologies for Nanoparticle Production -- Emerging Technologies to Increase the Bioavailability of Poorly Water-Soluble Drugs -- Scientific and Regulatory Considerations for Development and Commercialization of Poorly Water-Soluble Drugs.
    Abstract: The objective of this third edition is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at a minimum a working knowledge of each of the above mentioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop. Highlights the most recent advancements reported in the literature on technologies to improve the dissolution and bioavailability of poorly water soluble drugs Provides a comprehensive discussion of new technologies developed and recently over 40% updated new content Essential read for scientists and researchers in pharmaceutical, chemical, and agricultural industries since over 80% of newly discovered drugs are poorly water soluble.
    Type of Medium: Online Resource
    Pages: XII, 693 p. 280 illus., 138 illus. in color. , online resource.
    Edition: 3rd ed. 2022.
    ISBN: 9783030887193
    Series Statement: AAPS Advances in the Pharmaceutical Sciences Series, 50
    DDC: 615.19
    Language: English
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  • 2
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Environmental sciences Social aspects. ; Human geography. ; Cultural geography. ; Cultural property. ; Sociology, Urban. ; Environmental Social Sciences. ; Social and Cultural Geography. ; Cultural Heritage. ; Urban Sociology.
    Description / Table of Contents: Chapter 01 Rural Sustainability: challenges and opportunities -- Chapter 02 Case study: Rural revitalization in Hong Kong -- Chapter 03 Rural Sustainability: six core dimensions -- Chapter 04 Conclusion and the future of rural communities.
    Abstract: This book highlights the challenges and opportunities of (re)constructing a sustainable rural community on the outskirts of the urban community. Based on knowledge and experience accumulated through implementing a rural revitalisation project in Hong Kong since 2013, the book provides an in-depth analysis of a case study along with related concepts from the literature. In particular, the concept of rural resilience is broken down and used to examine how communities at the urban-rural interface can leverage their position and connections to (re)create vibrant sustainable communities. The revitalisation project was showcased in the databases of the United Nations Development Programme (UNDP)’s Equator Initiative and the International Partnership for the Satoyama Initiative (IPSI) as well as achieving Special Recognition for Sustainable Development in the UNESCO Asia-Pacific Awards for Cultural Heritage Conservation in 2020. This book teases out the key issues in the process of revitalising a rural community in the peri-urban context and examines the complexities embedded in each issue and how they can be addressed in the quest for rural sustainability.
    Type of Medium: Online Resource
    Pages: IX, 94 p. 5 illus., 3 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811658242
    Series Statement: SpringerBriefs on Case Studies of Sustainable Development,
    DDC: 304.2
    Language: English
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  • 3
    Keywords: Earth sciences. ; Geography. ; Sustainability. ; Renewable energy sources. ; Environmental management. ; Schools of economics. ; Economic policy. ; Earth and Environmental Sciences. ; Sustainability. ; Renewable Energy. ; Environmental Management. ; Heterodox Economics. ; Economic Policy.
    Description / Table of Contents: Introduction by William Rees -- Ch 1: The great acceleration, planetary boundaries and the Anthropocene, Will Steffen, Ch 2: Assessing natural environments: a summary, David Lindenmayer & Chris Dickman -- Ch 3: Human health and the natural environment, Colin D. Butler -- Ch 4:UN Sustainability Goals, Kerryn Higgs -- Ch. 5: The evolution of neoliberalism, John Quiggin -- Ch 6: Population growth, Ian Lowe -- Ch 7: Evaluation ‘The Limits to Growth’ 50 Years On, Kerryn Higgs -- Ch 8: The role of the fossil fuel industry, Ian Dunlop -- Ch 9: Economic failures of the IPCC process, Steve Keen -- Ch 10: Introduction to ecological economics, Philip Lawn & Stephen Williams -- Ch 11: Energy systems for sustainable prosperity, Mark Diesendorf -- Ch 12: Climate litigation and human rights, Michael Kirby & Sean Ryan -- Ch 13: What is a green deal without growth, Riccardo Mastini -- Ch 14: Paying a Green New Deal: MMT and the job guarantee, Steven Hall -- Ch 15: The Paradigm Shift, Stephen Williams -- Appendix.
    Abstract: This multidisciplinary book provides new insights and hope for sustainable prosperity given recent developments in economics – but only if swift and strong actions consistent with Earth’s biophysical limits and principles of justice are universally taken. It is one thing to put limits on resource throughput and waste generation to conform with the ecosphere’s biocapacity. It is another thing to efficiently allocate a sustainable rate of resource throughput and ensure it is equitably distributed in the form of final goods and services. While the separate but interdependent decisions regarding throughput, distribution, and allocation are the essence of ecological economics, dealing with them in a world that needs to cure its growth addiction requires a realistic understanding of macroeconomics and the fiscal capacity of currency-issuing central governments. Sustainable prosperity demands that we harness this understanding to carefully regulate the rate of resource throughput and manipulate macroeconomic outcomes to facilitate human flourishing. The book begins by outlining humanity’s current predicament of gross ecological overshoot and laments the half-century of missed opportunities since The Limits to Growth (1972). What was once economic growth has become, in many high-income countries, uneconomic growth (additional costs exceeding additional benefits), which is no longer advancing wellbeing. Meanwhile, low-income nations need a dose of efficient and equitable growth to escape poverty while protecting their environments and the global commons. The book argues for a synthesis of our increasing knowledge of the ecosphere’s limited carrying capacity and the power of governments to harness, transform, and distribute resources for the common good. Central to this synthesis must be a correct understanding of the difference between financial constraints and real resource constraints. While the latter apply to everyone, the former do not apply to currency-issuing central governments, which have much more capacity for corrective action than mainstream thinking perceives. The book joins the growing chorus of authoritative voices calling for a complete overhaul of the dominant economic system. We conclude with policy recommendations based on a new economics that, if implemented, would come close to guaranteeing a sustainable and prosperous future. Upon reading this book, at least one thing should be crystal clear: business as usual is not a viable option.
    Type of Medium: Online Resource
    Pages: VIII, 344 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030787950
    DDC: 500
    Language: English
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  • 4
    Publication Date: 2024-03-13
    Description: "Northern Australia is one of few tropical places left on Earth in which biodiversity—and the ecological processes underpinning that biodiversity—is still relatively intact. However, scientific knowledge of that biodiversity is still in its infancy and the region remains a frontier for biological discovery. The butterfly and diurnal moth assemblages of the area, and their intimate associations with vascular plants (and sometimes ants), exemplify these points. However, the opportunity to fill knowledge gaps is quickly closing: proposals for substantial development and exploitation of Australia’s north will inevitably repeat the ecological devastation that has occurred in temperate southern Australia—loss of species, loss of ecological communities, fragmentation of populations, disruption of healthy ecosystem function and so on—all of which will diminish the value of the natural heritage of the region before it is fully understood and appreciated. Written by several experts in the field, the main purpose of this atlas is to compile a comprehensive inventory of the butterflies and diurnal moths of northern Australia to form the scientific baseline against which the extent and direction of change can be assessed in the future. Such information will also assist in identifying the region’s biological assets, to inform policy and management agencies and to set priorities for biodiversity conservation."
    Keywords: Science ; Biodiversity ; Conservation ; Butterfly ; Moth ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RNC Applied ecology::RNCB Biodiversity ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RNK Conservation of the environment::RNKH Conservation of wildlife & habitats
    Language: English
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  • 5
    Publication Date: 2024-02-24
    Keywords: Aluminium, area, total counts; Antarctic Peninsula; Barium, area, total counts; bioturbation; bottom current; Bromine, area, total counts; Calcium, area, total counts; carbon burn-down; Chloride, area, total counts; Chromium, area, total counts; contourites; Copper, area, total counts; Depositional patterns and records in sediment drifts off the Antarctic Peninsula and West Antarctica; DEPTH, sediment/rock; GBC722 CORE_NO 722; Giant box corer; GKG; Ice-rafted debris; Iron, area, total counts; James Clark Ross; JR20150130; JR298; JR298-GBC722; Lead, area, total counts; Manganese, area, total counts; manganese enrichment; Nickel, area, total counts; non-steady-state diagenesis; Potassium, area, total counts; Rhodium, area, total counts; Rubidium, area, total counts; Sed_AntPen_WestAnt; sediment drifts; Silicon, area, total counts; Silver, area, total counts; Strontium, area, total counts; Sulfur, area, total counts; Tin, area, total counts; Titanium, area, total counts; W'Antarctic Peninsula rise, Crest of Drift 4 (near IODP 732-FULL2 site PEN-1); X-ray fluorescence (XRF); Zinc, area, total counts; Zirconium, area, total counts
    Type: Dataset
    Format: text/tab-separated-values, 2190 data points
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  • 6
    Publication Date: 2024-02-24
    Keywords: Aluminium, area, total counts; Antarctic Peninsula; Barium, area, total counts; bioturbation; bottom current; Bromine, area, total counts; Calcium, area, total counts; carbon burn-down; Chloride, area, total counts; Chromium, area, total counts; contourites; Copper, area, total counts; Depositional patterns and records in sediment drifts off the Antarctic Peninsula and West Antarctica; DEPTH, sediment/rock; Ice-rafted debris; Iron, area, total counts; James Clark Ross; JR20150130; JR298; JR298-PC727; Lead, area, total counts; Manganese, area, total counts; manganese enrichment; Nickel, area, total counts; non-steady-state diagenesis; PC; PC727 CORE_NO 727; Piston corer; Potassium, area, total counts; Rhodium, area, total counts; Rubidium, area, total counts; Sed_AntPen_WestAnt; sediment drifts; Silicon, area, total counts; Silver, area, total counts; Strontium, area, total counts; Sulfur, area, total counts; Tin, area, total counts; Titanium, area, total counts; W'Antarctic Peninsula rise, Near crest of Drift 7 (IODP 732-FULL2 site PEN-4B); X-ray fluorescence (XRF); Zinc, area, total counts; Zirconium, area, total counts
    Type: Dataset
    Format: text/tab-separated-values, 46230 data points
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  • 7
    Publication Date: 2024-02-24
    Keywords: Aluminium, area, total counts; Antarctic Peninsula; Barium, area, total counts; bioturbation; bottom current; Bromine, area, total counts; Calcium, area, total counts; carbon burn-down; Chloride, area, total counts; Chromium, area, total counts; contourites; Copper, area, total counts; Depositional patterns and records in sediment drifts off the Antarctic Peninsula and West Antarctica; DEPTH, sediment/rock; Ice-rafted debris; Iron, area, total counts; James Clark Ross; JR20150130; JR298; JR298-PC728; Lead, area, total counts; Manganese, area, total counts; manganese enrichment; Nickel, area, total counts; non-steady-state diagenesis; PC; PC728 CORE_NO 728; Piston corer; Potassium, area, total counts; Rhodium, area, total counts; Rubidium, area, total counts; Sed_AntPen_WestAnt; sediment drifts; Silicon, area, total counts; Silver, area, total counts; Strontium, area, total counts; Sulfur, area, total counts; Tin, area, total counts; Titanium, area, total counts; W'Antarctic Peninsula rise, Crest of Drift 6 (IODP 732-FULL2 site PEN-3B); X-ray fluorescence (XRF); Zinc, area, total counts; Zirconium, area, total counts
    Type: Dataset
    Format: text/tab-separated-values, 73200 data points
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  • 8
    Publication Date: 2024-02-24
    Keywords: Aluminium, area, total counts; Antarctic Peninsula; Barium, area, total counts; bioturbation; bottom current; Bromine, area, total counts; Calcium, area, total counts; carbon burn-down; Chloride, area, total counts; Chromium, area, total counts; contourites; Copper, area, total counts; Depositional patterns and records in sediment drifts off the Antarctic Peninsula and West Antarctica; DEPTH, sediment/rock; Ice-rafted debris; Iron, area, total counts; James Clark Ross; JR20150130; JR298; JR298-PC734; Lead, area, total counts; Manganese, area, total counts; manganese enrichment; Nickel, area, total counts; non-steady-state diagenesis; PC; PC734 CORE_NO 734; Piston corer; Potassium, area, total counts; Rhodium, area, total counts; Rubidium, area, total counts; Sed_AntPen_WestAnt; sediment drifts; Silicon, area, total counts; Silver, area, total counts; Strontium, area, total counts; Sulfur, area, total counts; Tin, area, total counts; Titanium, area, total counts; W'Antarctic Peninsula rise, Crest of Drift 5; X-ray fluorescence (XRF); Zinc, area, total counts; Zirconium, area, total counts
    Type: Dataset
    Format: text/tab-separated-values, 78712 data points
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  • 9
    Publication Date: 2024-02-24
    Keywords: Antarctic Peninsula; bioturbation; bottom current; Calcium carbonate; Carbon, organic, total; carbon burn-down; contourites; Depositional patterns and records in sediment drifts off the Antarctic Peninsula and West Antarctica; DEPTH, sediment/rock; GBC731 CORE_NO 731; Giant box corer; GKG; Ice-rafted debris; James Clark Ross; JR20150130; JR298; JR298-GBC731; manganese enrichment; Neogloboquadrina pachyderma sinistral, δ13C; Neogloboquadrina pachyderma sinistral, δ18O; non-steady-state diagenesis; Salt-corrected; Sed_AntPen_WestAnt; sediment drifts; Size fraction 〈 0.063 mm, mud, silt+clay; Size fraction 〉 2 mm, gravel; Size fraction 2.000-0.063 mm, sand; W'Antarctic Peninsula rise, Crest of Drift 5 (IODP 732-FULL2 site PEN-2B); Water content, wet mass
    Type: Dataset
    Format: text/tab-separated-values, 35 data points
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  • 10
    Publication Date: 2024-02-24
    Keywords: Antarctic Peninsula; Bellingshausen Sea, Near crest of mound (IODP 732-FULL2 site BELS-2C); bioturbation; bottom current; Calcium carbonate; Carbon, organic, total; carbon burn-down; contourites; Depositional patterns and records in sediment drifts off the Antarctic Peninsula and West Antarctica; DEPTH, sediment/rock; GBC725 CORE_NO 725; Giant box corer; GKG; Ice-rafted debris; James Clark Ross; JR20150130; JR298; JR298-GBC725; manganese enrichment; Neogloboquadrina pachyderma sinistral, δ13C; Neogloboquadrina pachyderma sinistral, δ18O; non-steady-state diagenesis; Salt-corrected; Sed_AntPen_WestAnt; sediment drifts; Size fraction 〈 0.063 mm, mud, silt+clay; Size fraction 〉 2 mm, gravel; Size fraction 2.000-0.063 mm, sand; Water content, wet mass
    Type: Dataset
    Format: text/tab-separated-values, 53 data points
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