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  • 2020-2024  (1,827)
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  • 1
    Online Resource
    Online Resource
    Messenger RNA Therapeutics (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Medicinal chemistry. ; Nanomedicine. ; Cancer Treatment. ; Medical Genetics. ; Medicinal Chemistry. ; Nanomedicine and Nanotoxicology. ; Cancer Therapy.
    Description / Table of Contents: The Democratization of RNA Therapeutics -- Supramolecular Strategies for mRNA Delivery -- In Vitro-Transcribed mRNAs as a New Generation of Therapeutics in the Dawn of 21st Century: Exploitation of Peptides as Carriers for their Intracellular Delivery -- Effective Delivery of mRNA Therapeutics and Vaccines Using Lipid Nanoparticles -- Messenger RNA Therapeutics -- Formulation, Delivery and Application of mRNA Therapeutics In Respiratory Diseases -- Clinical Applications of mRNA Formulated In Lipid Nanoparticles -- Preparation of Messenger RNA Loaded Nanomedicine Applied on Tissue Engineering And Regenerative Medicine -- Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics: Immune Activation By Ionizable Cationic Lipids -- Adjuvants, the Elephant in the Room for RNA Vaccines -- Addressing Skin with Modified mRNA Constructs for Novel Therapies -- mRNA-Based Cancer Immunotherapies -- From Bench to Bedside: The Journey of an mRNA Drug Candidate Into a Medicine -- Synthetic mRNA Gene Therapies for Chronic HBV Infection -- Delivery Vehicles for Self-Amplifying RNA -- Delivery Technologies of mRNA Vaccines -- Nanosystems: The Key in Formulations of mRNA for Several Pathologies -- Messenger RNA Nanoformulation For Cancer Vaccine -- Preparation of Synthetic mRNAs for In Vivo Applications – Overview and Considerations -- Messenger RNA for Prophylaxis -- Nuclear Export of mRNA with Disease Pathogenesis and Therapeutic Potentials -- Messenger RNA Therapeutics: Start of a New Era in Medicine -- mRNA Delivery Technologies for Therapeutic Applications.
    Abstract: This book focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs. In the past 30 years, extensive research and technological development in many areas have contributed to the emergence of in vitro transcribed mRNA as a therapeutic that has now reached clinical testing. Formulations that protect the mRNA from nucleases and accelerate its cellular uptake, combined with improvements to the mRNA molecules themselves, have been critical advancements for mRNAs to become viable therapeutics. Though once regarded as a serious impediment, the transient nature of mRNA technology is now considered a major advantage in making mRNA therapies safe and, ultimately, a potential game changer in the field of medicine. This new book in the RNA Technologies series provides a state-of-the-art overview on the emerging field of mRNA therapeutics covering essential strategies for formulation, delivery, and application. It also reviews the promising role in cancer immunotherapy, respiratory diseases, and chronic HBV infection and discusses RNA vaccines in light of the current COVID-19 pandemic. mRNA-based approaches have great potential to revolutionize molecular biology, cell biology, biomedical research, and medicine. Thus, this handbook is an essential resource for researchers in academia and industry contributing to the development of this new area of therapeutics.
    Type of Medium: Online Resource
    Pages: XII, 446 p. 68 illus., 57 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031084157
    Series Statement: RNA Technologies, 13
    URL: https://doi.org/10.1007/978-3-031-08415-7
    DOI: 10.1007/978-3-031-08415-7
    DDC: 616.042
    Language: English
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  • 2
    Online Resource
    Online Resource
    Trials for Cerebellar Ataxias : From Cellular Models to Human Therapies (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Neurology . ; Pharmaceutical chemistry. ; Cognitive neuroscience. ; Neuroscience. ; Neurology. ; Pharmaceutics. ; Cognitive Neuroscience.
    Description / Table of Contents: Part I: Basic Science of Cerebellum and Ataxias -- Functional anatomy of the cerebellum -- Cerebellar physiology -- Cerebellar biochemistry/pharmacology -- Genetics of dominant ataxias -- Autosomal and X-linked degenerative ataxias: from genetics to promising therapeutics -- Seeking therapies for Spinocerebellar Ataxia: from gene silencing to systems-based approaches -- Ion Channel Genes and Ataxia -- Part II: Biomarkers and tools of trials -- How to Design a Therapeutic Trial in SCAs -- Therapy development for spinocerebellar ataxia: Rating Scales and Biomarkers -- Clinical rating scales for ataxia -- Scale for Ocular motor Disorders in Ataxia (SODA): Procedures and Basic Understanding -- Cerebellar learning in the prism adaptation task -- Blood and CSF biomarkers in autosomal dominant cerebellar ataxias -- Part III: Autosomal Dominant Cerebellar Ataxias -- Riluzole in progressive cerebellar ataxias -- ASOs against ATXN2 in preclinical and phase 1 trials -- Antisense oligonucleotide therapy against SCA3 -- Spinocerebellar ataxia type 7: From mechanistic pathways to therapeutic opportunities -- Experimental neurotransplantation for cerebellar ataxias -- Development of mesenchymal stem cells therapy for the treatment of polyglutamine SCA: from bench to bedside -- Cerebello-Spinal tDCS as Rehabilitative Intervention in Neurodegenerative Ataxia -- Cerebellar Transcranial Magnetic Stimulation in Cerebellar Ataxias -- Physical therapy in Cerebellar Ataxia -- Part IV: Autosomal Recessive Cerebellar Ataxias -- Recent advances on therapeutic approaches for Friedreich’s Ataxia -- Therapeutic use of interferon gamma in Friedreich ataxia -- Metabolic treatments of cerebellar ataxia -- Clinical Trials in Fragile X-Associated Tremor/Ataxia Syndrome -- Part V: Sporadic Ataxias -- Therapeutic strategies in immune-mediated cerebellar ataxias -- Coenzyme Q10 in MSA -- State of the Art and History of Therapeutics in Ataxias.
    Abstract: Despite the critical importance of the cerebellum in brain functions, the scientific community still lacks effective treatments for most cerebellar ataxias. This book provides a link between the pathogenesis and therapies of cerebellar ataxias while also providing a comprehensive assessment of the preclinical and clinical trials dedicated to cerebellar ataxias over the past 20 years of progress. This is the first book fully dedicated to the trials and therapies of these disorders. It is a truly authoritative and comprehensive reference and comes at a time of major advances in genetic tools and neuroimaging assessments. The coverage begins by laying a foundation of the basic science of the cerebellum and ataxias, proceeds to discuss biomarkers and the tools of trials, offers guidelines on conducting trials, and then explores the full range of therapeutics and their trials, including gene therapy and cell transplantation. The authors are top experts on cerebellar research and the contributing authors have all made seminal contributions in the field.
    Type of Medium: Online Resource
    Pages: XI, 727 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031243455
    Series Statement: Contemporary Clinical Neuroscience,
    URL: https://doi.org/10.1007/978-3-031-24345-5
    DOI: 10.1007/978-3-031-24345-5
    DDC: 612.8
    Language: English
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  • 3
    Online Resource
    Online Resource
    Varicella-zoster Virus : Genetics, Pathogenesis and Immunity (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Virology. ; Immunology. ; Human physiology. ; Vaccines Biotechnology. ; Biomaterials. ; Virology. ; Immunology. ; Human Physiology. ; Biomaterials-Vaccines.
    Description / Table of Contents: Varicella-zoster Virus - Genetics, Molecular Evolution, and Recombination -- The structures and functions of VZV glycoproteins -- Modulation of apoptosis and cell death pathways by Varicella zoster virus -- Modulation of host cell signaling pathways by varicella-zoster virus -- Modulation of MHC and MHC-like molecules by Varicella Zoster Virus -- Varicella Zoster Virus Neuronal Persistence and Reactivation modeled in-vitro -- Humanized Severe Combined Immunodeficient (SCID) Mouse Models for Varicella-Zoster Virus Pathogenesis -- Simian Varicella Virus: Molecular Virology and mechanisms of pathogenesis -- A guide to preclinical models of zoster-associated pain and postherpetic neuralgia -- Immune Responses to Varicella-Zoster Virus Vaccines -- Common features between stroke following varicella in children and stroke following herpes zoster in adults.
    Abstract: This edited volume provides insights about the molecular virology, pathoenesis of infection and host responses to varicella-zoster virus, which is a medically important human herpesvirus. The chapters not only discuss genetics and molecular evolution of the virus, but also new structure-based knowledge on the functions of viral glycoproteins. Further, the authors illustrate how mechanisms from the virus are used to take over and remodel host cells during pathogeneis. These mechanisms also enable viral modulation of host cells and evasion of the host immune response. Part of these evasion and survival strategies, is the reaction to triggered host cell responses like autophagy, the stress response, modulation of apoptosis and other cell death pathways. This hands-on knowledge is crucial for students and clinicians in Virology, Immunology, and Infectious Diseases. Chapter "Common features between stroke following varicella in children and stroke following herpes zoster in adults" is available open access under a Creative Commons Attribution 4.0 International License via Springerlink.com.
    Type of Medium: Online Resource
    Pages: VIII, 272 p. 39 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031153051
    Series Statement: Current Topics in Microbiology and Immunology, 438
    URL: https://doi.org/10.1007/978-3-031-15305-1
    DOI: 10.1007/978-3-031-15305-1
    DDC: 579.2
    Language: English
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  • 4
    Online Resource
    Online Resource
    Epitranscriptomics (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Epigenetics. ; RNA Metabolism. ; Biochemistry. ; Bioinformatics. ; Epigenetics. ; RNA Metabolism. ; Biological Chemistry. ; Bioinformatics.
    Description / Table of Contents: Epitranscriptomic Modifications and How to Find them -- Epitranscriptomic Signature in Neural Development and Disease -- The Emerging Neuroepitranscriptome -- Epitranscriptomics and Diseases -- Epitranscriptomic Marks and Systems Involved in Gene Regulation, Development and Disease -- Experimental Approaches and Computational Workflows for Systematic Mapping and Functional Interpretation of RNA Modifications -- RNA Modifications: The Mediator Between Cellular Stresses and Biological Effects -- Computational Prediction and Experimental Validation of Specific Modified RNA Sites -- Regulation of RNA Stability Utilizing RNA Modification -- Dynamic RNA Modification Upon Extracellular Stimulus -- RNA Methylation in Cancer -- Regulation of RNA Methylation yy TET Enzymes -- RNA N6-Methyladenosine and G-Quadruplex Structures in Bacteria -- RNA N6-Methyladenosine Chemical Modification as a Therapeutic Target -- Cap-Adjacent m6Am and its Effects On mRNA -- N6-Methyladenosine in The Heart -- The m6a RNA Methylation Regulates Oncogenic Signaling Pathways Driving Cell Transformation and Carcinogenesis -- Psivar: A Database of Functional Variants Involved in Pseudouridylation (Ψ) with Implications for Disease Pathogenesis -- C-to-U RNA Editing by Mammalian APOBEC Enzymes -- The Powerful Mechanism of RNA Editing and its Therapeutic Potentials -- Noncanonical Caps in RNA -- Mass Spectrometry-Based Methods for Characterization of Hypomodifications in tRNA -- Dynamic mRNA Modifications in Plants -- The Mammalian Mitochondrial Epitranscriptome -- Epitranscriptomics Modifications of Micrornas: Classes, Detection, Impact on their Functionality and Next Frontiers -- “Look Before You Leap” when Editing the Introns, or the Secrets Behind the Intronic Post-Transcriptional Modification -- Functional Links Between the Internal N6-Methyl Adenosine Modifications in mRNAs and Human Diseases -- RNA Modifications in Neurodevelopment and Neurodegenerations -- Conventional and Advanced Techniques for Methyl-6-Adenosine Modification Mapping in Transcripts -- Mechanisms and Therapeutic Applications of RNA-Guided RNA Pseudouridylation -- Epitranscriptomic Modifications in lnRNA and miRNA in Cancer and Other Diseases -- RNA m6A and Adipogenesis.
    Abstract: This book reviews a novel and exciting field of cellular and molecular biology called epitranscriptomics, which focuses on changes in an organism’s cells resulting from the posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Exploring the mechanisms underlying RNA modifications and RBP function is an emerging area of biomedical research, taking the study of gene regulation a step beyond epigenetics. This book reveals that the RNA molecule is not just an information-carrying molecule with some secondary structures. Accordingly, how RNA is modified, regulated, packaged, and controlled is an important aspect. Leading experts address questions such as where the over 170 distinct posttranscriptional RNA modifications are located on the genome, what percentage of mRNAs and noncoding RNAs these modifications include, and how an RNA modification impacts a person’s biology. In closing, the book reviews the role of RNA modifications and RBPs in a variety of diseases and their pathogenesis. Addressing some of the most exciting challenges in epitranscriptomics, this book provides a valuable and engaging resource for researchers in academia and industry studying the phenomena of RNA modification.
    Type of Medium: Online Resource
    Pages: X, 632 p. 90 illus., 84 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030716127
    Series Statement: RNA Technologies, 12
    URL: https://doi.org/10.1007/978-3-030-71612-7
    DOI: 10.1007/978-3-030-71612-7
    DDC: 572.865
    Language: English
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  • 5
    Online Resource
    Online Resource
    Ancillary Benefits of Climate Policy : New Theoretical Developments and Empirical Findings (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Environmental economics. ; Environment. ; Finance, Public. ; Environmental management. ; Environmental Economics. ; Environmental Sciences. ; Public Economics. ; Environmental Management.
    Description / Table of Contents: Ancillary Benefits and Development Co-effects -- Conceptual and Theoretical Approaches for the Analysis of Ancillary Benefits -- Ancillary Benefits in Different Sectors and in Adaptation to Climate Change -- Climate Actions in Urban Areas and their Ancillary Benefits. .
    Abstract: This volume presents new developments in the research on ancillary benefits. Twenty years after the influential OECD report on ancillary benefits, the authors discuss theoretical innovations and offer new empirical findings on various ancillary effects in different world regions. Covering topics such as ancillary health effects associated with reduced air pollution, the influence of ancillary benefits on international cooperation on climate protection, co-effects of carbon capture and storage, ancillary effects of adaptation to climate change, multi-criteria decision analysis covering multiple effects of climate protection actions, and the analysis of primary and ancillary effects within an impure public goods framework, it provides starting points for further research on integrated climate policies seeking to address a range of policy objectives simultaneously.
    Type of Medium: Online Resource
    Pages: X, 345 p. 46 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030309787
    Series Statement: Springer Climate,
    URL: https://doi.org/10.1007/978-3-030-30978-7
    DOI: 10.1007/978-3-030-30978-7
    DDC: 333.7
    Language: English
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  • 6
    Online Resource
    Online Resource
    Selected Studies in Environmental Geosciences and Hydrogeosciences : Proceedings of the 3rd Conference of the Arabian Journal of Geosciences (CAJG-3) (2023)
    Cham :Springer Nature Switzerland :
    Details
    Keywords: Physical geography. ; Water. ; Hydrology. ; Climatology. ; Ecology . ; Earth System Sciences. ; Water. ; Climate Sciences. ; Ecology.
    Description / Table of Contents: Section 1: Atmospheric Sciences, Meteorology, Climatology, Oceanography -- Section 2: Biogeochemistry, Geobiology, Geoecology, Geoagronomy -- Section 3: Environmental Earth Sciences and Geohazards -- Section 4: Hydrology, Hydrochemistry, Hydrogeology.
    Abstract: This book gives a general overview on current research focusing on geoenvironmental issues and challenges in hydrogeosciences in the Middle East and Mediterranean region and surrounding areas. The book is based on the accepted papers for oral/poster presentations at the 3rd Springer Conference of the Arabian Journal of Geosciences (CAJG-3). Studies discuss the latest advances in geoenvironmental and hydrogeosciences from diverse backgrounds including climate change, geoecology, biogeochemistry, water resources management, and environmental monitoring and assessment. It shares insights on how the understanding of ecological, climatological, oceanic, and hydrological processes is the key for improving practices in environment management. It is of interest to scientists, engineers, practitioners, and policymakers in the field of environmental sciences including climatology, oceanography, ecology, biogeochemistry, environmental management, hydrology, hydrogeology, and geosciences in general. In particular, this book is of great value to students and environment-related professionals for further investigations on the state of earth systems.
    Type of Medium: Online Resource
    Pages: XXIX, 271 p. 181 illus., 166 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031438035
    Series Statement: Advances in Science, Technology & Innovation, IEREK Interdisciplinary Series for Sustainable Development,
    URL: https://doi.org/10.1007/978-3-031-43803-5
    DOI: 10.1007/978-3-031-43803-5
    DDC: 550
    Language: English
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  • 7
    Online Resource
    Online Resource
    Iron Geochemistry: An Isotopic Perspective (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Geochemistry. ; Mass spectroscopy. ; Biochemistry. ; Oceanography. ; Geochemistry. ; Mass Spectrometry. ; Biochemistry. ; Ocean Sciences.
    Description / Table of Contents: Introduction and Overview -- Analytical Methods -- Fe Isotope Fractionation Factors -- High-Temperature Fe Isotope Geochemistry -- The modern surficial world -- The Ancient Earth.
    Abstract: This book provides a comprehensive summary of research to date in the field of stable iron isotope geochemistry. Since research began in this field 20 years ago, the field has grown to become one of the major research fields in "non-traditional" stable isotope geochemistry. This book reviews all aspects of the field, from low-temperature to high-temperature processes, biological processes, and cosmochemical processes. It provides a detailed history and state-of-the art summary about analytical methods to determine Fe-isotope ratios and discusses analytical and sample prospects.
    Type of Medium: Online Resource
    Pages: XII, 360 p. 129 illus., 123 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030338282
    Series Statement: Advances in Isotope Geochemistry,
    URL: https://doi.org/10.1007/978-3-030-33828-2
    DOI: 10.1007/978-3-030-33828-2
    DDC: 551.9
    Language: English
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  • 8
    Online Resource
    Online Resource
    Using Historical Maps in Scientific Studies : Applications, Challenges, and Best Practices (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Geographic information systems. ; Physical geography. ; Computer vision. ; Geographical Information System. ; Physical Geography. ; Computer Vision.
    Abstract: This book illustrates the first connection between the map user community and the developers of digital map processing technologies by providing several applications, challenges, and best practices in working with historical maps. After the introduction chapter, in this book, Chapter 2 presents a variety of existing applications of historical maps to demonstrate varying needs for processing historical maps in scientific studies (e.g., thousands of historical maps from a map series vs. a few historical maps from various publishers and with different cartographic styles). Chapter 2 also describes case studies introducing typical types of semi-automatic and automatic digital map processing technologies. The case studies showcase the strengths and weaknesses of semi-automatic and automatic approaches by testing them in a symbol recognition task on the same scanned map. Chapter 3 presents the technical challenges and trends in building a map processing, modeling, linking, and publishing framework. The framework will enable querying historical map collections as a unified and structured spatiotemporal source in which individual geographic phenomena (extracted from maps) are modeled (described) with semantic descriptions and linked to other data sources (e.g., DBpedia, a structured version of Wikipedia). Chapter 4 dives into the recent advancement in deep learning technologies and their applications on digital map processing. The chapter reviews existing deep learning models for their capabilities on geographic feature extraction from historical maps and compares different types of training strategies. A comprehensive experiment is described to compare different models and their performance. Historical maps are fascinating to look at and contain valuable retrospective place information difficult to find elsewhere. However, the full potential of historical maps has not been realized because the users of scanned historical maps and the developers of digital map processing technologies are from a wide range of disciplines and often work in silos. Each chapter in this book can be read individually, but the order of chapters in this book helps the reader to first understand the “product requirements” of a successful digital map processing system, then review the existing challenges and technologies, and finally follow the more recent trend of deep learning applications for processing historical maps. The primary audience for this book includes scientists and researchers whose work requires long-term historical geographic data as well as librarians. The secondary audience includes anyone who loves maps!
    Type of Medium: Online Resource
    Pages: X, 114 p. 76 illus., 75 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783319669083
    Series Statement: SpringerBriefs in Geography,
    URL: https://doi.org/10.1007/978-3-319-66908-3
    DOI: 10.1007/978-3-319-66908-3
    DDC: 910.285
    Language: English
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  • 9
    Online Resource
    Online Resource
    Selected Studies in Geomorphology, Sedimentology, and Geochemistry : Proceedings of the 3rd Conference of the Arabian Journal of Geosciences (CAJG-3) (2023)
    Cham :Springer Nature Switzerland :
    Details
    Keywords: Geomorphology. ; Soil science. ; Archaeology. ; Earth sciences. ; Geography. ; Oceanography. ; Geomorphology. ; Soil Science. ; Archaeology. ; Earth and Environmental Sciences. ; Ocean Sciences.
    Description / Table of Contents: Section 1: Atmospheric Sciences, Meteorology, Climatology, Oceanography -- Section 2: Biogeochemistry, Geobiology, Geoecology, Geoagronomy -- Section 3: Environmental Earth Sciences and Geohazards -- Section 4: Hydrology, Hydrochemistry, Hydrogeology.
    Abstract: This book is based on the papers accepted for presentation during the 3rd Springer Conference of the Arabian Journal of Geosciences (CAJG-3). The book is of interest to all researchers in the fields of geomorphology, sedimentology, and geochemistry. Papers in the field of geomorphology deal with topics related to fault slip and incision rates, soil science, landslides and debris flows, coastal processes, and geoarcheology and geoheritage. Papers in the field of sedimentology cover research studies in stratigraphy and environmental, tectonic, and diagenetic processes, together with studies focusing on the evolutionary, biostratigraphic, and paleo-environmental significance of paleontology. This section also contains papers on marine geosciences, from molecular proxies related to climate to geophysical surveys. The third set of papers focuses on studies related to geochemistry that are focused on sedimentary geochemistry and mineralogical characterization, magmatic and metamorphic processes and products, and the origin and exploration of mineral deposits. This book resumes the current situation related to the abovementioned topics mainly in the Mediterranean realm and its surroundings. The book is of interest to all researchers, practitioners, and students in the fields of geomorphology, sedimentology, and geochemistry.
    Type of Medium: Online Resource
    Pages: XXIX, 201 p. 152 illus., 136 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031437441
    Series Statement: Advances in Science, Technology & Innovation, IEREK Interdisciplinary Series for Sustainable Development,
    URL: https://doi.org/10.1007/978-3-031-43744-1
    DOI: 10.1007/978-3-031-43744-1
    DDC: 551.41
    Language: English
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  • 10
    Online Resource
    Online Resource
    Pineal Region Lesions : Management Strategies and Controversial Issues (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Nervous system Surgery. ; Neurology . ; Radiology. ; Pediatrics. ; Neurosurgery. ; Neurology. ; Radiology. ; Pediatrics.
    Description / Table of Contents: I Overview -- 1 Historical landmarks in pineal region surgery -- 2 Pineal region anatomy -- 3 Pathology of Pineal Region Lesions -- 4 Clinical presentation -- 5 Imagistic diagnosis -- 6 The Usefulness of Biomarkers for Diagnosis -- 7 Surgical Adjuvants for pineal region approach -- II Surgical approaches for pineal region lesions -- 8 Supracerebellar infratentorial approach -- 9 Occipital transtentorial approach -- 10 Transcallosal approach -- 11 Endoscopic approaches for pineal region lesions -- 12 Management of Hydrocephalus -- III Adjuvant therapies -- 13 Radiosurgery -- 14 Other radiotherapeutic techniques -- 15 Chemotherapy -- IV Pineal region tumors -- 16 Tumors of Pineal Cell Origin -- 17 Tumors of germ cell origin -- 18 Tumors of glial origin -- 19 Meningiomas of the pineal region -- 20 Metastatic tumors -- V Vascular lesions of the pineal region -- 21 Arterio-venous malformations -- 22 Cavernomas.-23 Vein of Galen Aneurismal Malformation -- VI Cysts and Cyst -Like Lesions of the pineal region -- 24 Epidermoids and Dermoids -- 25 Pineal Cyst -- VII Miscellanea -- 26 Management algorithms -- 27 Conclusions.
    Abstract: Neurosurgical lesions of the pineal region are extremely rare, accounting for roughly 1% of the total number of neurosurgical expansive lesions in modern practice. This book offers an up-to-date review of the relevant literature, combined with the personal perspectives of some highly experienced figures in the field. The book is divided into two main parts, the first of which offers an overview of the pineal region from an anatomic, pathologic, imaging and therapeutic perspective. Special attention is given to surgical approaches to pineal region lesions. Microsurgical techniques are presented, together with detailed indications regarding specific locations of these lesions, specific complications, and controversial aspects concerning some of the approaches. A dedicated chapter addresses endoscopic techniques, their indications and limitations. Adjuvant therapies are also discussed, along with their particular indications and debated aspects. In turn, the chapters in the second part cover specific lesions such as pineal region tumors, vascular lesions, and cystic and cyst-like lesions. Regarding pineal region tumors, the most frequent pathologies are presented in the most comprehensive and practical manner possible, with special attention to the appropriate therapeutic management for each type. Further, there is a dedicated chapter on pineal region cysts. Given its depth of content, the book will allow neurosurgeons and specialists to greatly expand their understanding of pineal region lesions in daily clinical practice.
    Type of Medium: Online Resource
    Pages: XI, 260 p. 113 illus., 82 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030509132
    URL: https://doi.org/10.1007/978-3-030-50913-2
    DOI: 10.1007/978-3-030-50913-2
    DDC: 617.48
    Language: English
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