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  • 2020-2024  (2,088)
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  • 1
    Online Resource
    Online Resource
    Sleep and its Disorders : Translational Medicine (2022)
    Dordrecht :Springer Netherlands :
    Details
    Keywords: Neurology . ; Internal medicine. ; Psychiatry. ; Neurology. ; Internal Medicine. ; Psychiatry.
    Description / Table of Contents: Chapter 1. Evolving approaches to identifying genetic risk variants for sleep disorders -- Chapter 2. Neurobiology of sleep-wake control -- Chapter 3. Prostaglandins, adenosine and histaminergic system in the regulation of sleep and wakefulness -- Chapter 4.Sleep and Neuronal Plasticity -- Chapter 5. Epidemiology of Insufficient Sleep -- Chapter 6.Social Factors in Insufficient Sleep -- Chapter 7. Sleep Loss and the Unfolded Protein Response -- Chapter 8. Biological and genetic mechanisms of sleepiness in Obstructive Sleep Apnea and Cardiovascular Disease -- Chapter 9.Diaphragm EMG recording and its application in sleep medicine -- Chapter 10. Chronic Intermittent Hypoxia in Patients with OSA -- Chapter 11.Neural injury in models of intermittent hypoxia -- Chapter 12. Narcolepsy and Orexin/hypocretin -- Chapter 13.Circadian Rhythm Sleep-Wake Disorders: Mechanisms and Treatment.
    Abstract: The aim of this book is to provide health care professionals with an overview of the main aspects of recent advances in sleep medicine, with an emphasis on advancing basic science into clinical medicine. It is divided into three main parts. The first part is to cover the basic sleep mechanisms which includes genetics in sleep, and neural and humoral regulation of sleep and wakefulness. The second part focuses on the epidemiology of sleep, and the final part consists of the pathophysiological mechanisms of snoring and sleep apnea and other common sleep disorders as well as the consequences. The content of this book is written by experts and sleep specialists from all over the world and this book aims to optimize the health of individuals by “translating” bench side findings into clinical practice.
    Type of Medium: Online Resource
    Pages: VI, 282 p. 43 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789402421682
    Series Statement: Translational Medicine Research,
    URL: https://doi.org/10.1007/978-94-024-2168-2
    DOI: 10.1007/978-94-024-2168-2
    DDC: 616.8
    Language: English
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  • 2
    Online Resource
    Online Resource
    Biochemistry and Cell Biology of Ageing: Part IV, Clinical Science (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Aging. ; Cytology. ; Clinical biochemistry. ; Proteins . ; Ageing. ; Cell Biology. ; Medical Biochemistry. ; Protein Biochemistry.
    Description / Table of Contents: Chapter 1:Introduction: Historical Development and Progression of Clinical Research on Ageing -- Chapter 2:Bone Cells Metabolic Changes Induced by Ageing -- Chapter 3:Chronic Inflammation as an Underlying Mechanism of Ageing and Ageing-related Diseases -- Chapter 4: Heart Disease and Ageing: The roles of Senescence, Mitochondria and Telomerase in Cardiovascular Disease -- Chapter 5: Chronic Kidney Disease and the Exposome of Ageing -- Chapter 6: Sarcopenia and Ageing -- Chapter 7: Tendon Ageing -- Chapter 8: Virus Infections in Older People -- Chapter 9: Models and Biomarkers for Ovarian Ageing -- Chapter 10: Ageing and the Autonomic Nervous System -- Chapter 11: Astrocytes in Ageing -- Chapter 12: Hearing and Ageing -- Chapter 13: Melatonin and Ageing -- Chapter 14: Protein and Energy Supplements for the Elderly -- Chapter 15: Ageing, Metabolic Dysfunction, and the Therapeutic Role of Antioxidants -- Chapter 16: Clinical Ageing.
    Abstract: This book provides an up-to-date overview of key areas of ageing research and bridges the gap between the subcellular events and the reality of ageing as seen in clinical practice. To this end, the reader learns about the historical development and progression of clinical ageing research. All chapters address the biochemistry or cell biology of various ageing events (to the extent that the data are available) and work their way to the clinical understanding we have of ageing. The focus of this volume is on how dietary restriction, virus infection and chronic inflammation affect the ageing process. Additionally, this book discusses how phosphate metabolism and metabolic dysfunction contribute to ageing events and how various organs and tissues (e.g. tendons, ears, heart muscle, and the endocrine system) age. This book follows on from Parts I, II and III of Biochemistry and Cell Biology of Ageing within the Subcellular Biochemistry book series and aims to bring the subcellular and clinical areas into closer contact by including interesting and significant biomedical ageing topics that were not included in the earlier volumes. Comprehensive and cutting-edge, this book is a valuable resource for experienced researchers and early career scientist alike, who are interested in learning more about the fascinating and challenging question of why and how our cells age.
    Type of Medium: Online Resource
    Pages: VIII, 458 p. 48 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031265761
    Series Statement: Subcellular Biochemistry, 103
    URL: https://doi.org/10.1007/978-3-031-26576-1
    DOI: 10.1007/978-3-031-26576-1
    DDC: 571.878
    Language: English
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  • 3
    Online Resource
    Online Resource
    Aleocharine Rove Beetles of British Columbia: A Hotspot of Canadian Biodiversity (Coleoptera, Staphylinidae) (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Invertebrates. ; Evolution (Biology). ; Anatomy, Comparative. ; Biology Technique. ; Biodiversity. ; Conservation biology. ; Ecology . ; Invertebrate Zoology. ; Evolutionary Theory. ; Animal Anatomy. ; Experimental Organisms. ; Biodiversity. ; Conservation Biology.
    Description / Table of Contents: Introduction -- Historical review of research on British Columbia taxa -- Material and Methods -- British Columbia – hotspot of Canadian biodiversity -- Faunal analysis and discussion -- List of recorded species of eastern Canadian Aleocharinae and their composition -- Key to tribes of Aleocharinae occurring in eastern Canada -- Tribe Gymnusini Heer, 1839 -- Tribe Aleocharini Fleming, 1821 -- Tribe Oxypodini C.G. Thomson, 1859 -- Tribe Tachyusini C.G. Thomson, 1859 -- Tribe Hypocyphtini Laporte, 1835 -- Tribe Myllaenini Ganglbauer, 1895 -- Tribe Liparocephalini Fenyes, 1918 -- Tribe Autaliini C.G. Thomson, 1859 -- Tribe Homalotini Heer, 1839 -- Tribe Placusini Mulsant and Rey, 1871 -- Tribe Athetini Casey, 1910 -- Tribe Falagriini Mulsant and Rey, 1873 -- Tribe Lomechusini Fleming, 1821.
    Abstract: Aleocharine beetles are among the most poorly known and difficult-to-identify groups of Coleoptera worldwide. This book presents the first comprehensive synopsis of aleocharine rove beetle species (Coleoptera, Staphylinidae) from British Columbia, Canada. It is important to generate a structured inventory of species in hotspots of biodiversity like British Columbia, to provide baseline biodiversity data for monitoring species responses related to climate change. It is the first book to treat and illustrate every recorded and new species. For every species, color illustrations are provided, including color habitus and genital diagnostic structures of both sexes. Two hundred and twenty-seven valid species, including 14 new species, 16 new generic records, and 36 (excluding new species) new provincial and 6 state records, in 79 genera and 14 tribes.Tribes and subtribes are arranged in phylogenetic order as it is currently recognized, and genera and subgenera are listed alphabetically within each tribe or subtribe. Species are listed alphabetically or in species groups to better reflect their relationships. Species distribution is listed by provinces and territories in Canada and states in the United States, and the geographic origin of each species is categorized as native, Holarctic, adventive or undetermined (either adventive or Holarctic). Every species is presented with a morphological diagnosis including external and genital characters of both sexes. Collection and habitat data are presented for each species, including collecting period, and collecting methods. A list of all eastern Canadian species with their currently known distribution in North America is presented at the end of the book.
    Type of Medium: Online Resource
    Pages: XVI, 631 p. 267 illus., 256 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030361747
    URL: https://doi.org/10.1007/978-3-030-36174-7
    DOI: 10.1007/978-3-030-36174-7
    DDC: 592
    Language: English
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  • 4
    Online Resource
    Online Resource
    Bambara groundnut: Utilization and Future Prospects (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Agriculture. ; Food science. ; Environmental sciences Social aspects. ; Botany. ; Nutrition   . ; Agriculture. ; Food Science. ; Environmental Social Sciences. ; Plant Science. ; Nutrition.
    Description / Table of Contents: Ch 1: Introduction -- Ch 2: Physical and engineering properties of the seed -- Ch 3: Breeding and world production -- Ch 4: Functional food development and products -- Ch 5: Innovations in Bambara ground nut processing -- Ch 6: Composition and nutritional profile -- Ch 7: Ingredients and novel applications -- Ch 8: Food components and consumption trends -- Ch 9: Bambara ground nut as a climate smart crop -- Ch 10: Current and innovative packaging technologies for Bambara ground nut -- Ch 11 Integrating text mining and network analysis for potential application of Bambara ground nut -- Ch 12 Digitalization of Bambara food value -- Ch 13 Ethnonutrition and ethnomedical knowledge associated with Bambara ground nut -- Ch 14 Current and future research directions -- Ch 15 Conclusion -- Ch 16 References.
    Abstract: The Bambara groundnut (BGN) or Vigna subterranea is an extremely hardy grain legume. As it produces reasonable yields even under conditions of drought and low soil fertility, it is also a climate-smart crop. Previously underutilized, BGN is the subject of growing interest among researchers and consumers for its balanced nutritional profile. Indigenous consumers of BGN report medicinal benefits from the plant; however, such knowledge is at risk of being lost with the urbanization and changing lifestyles of younger generations. To date, there is no comprehensive resource on the Bambara groundnut, despite market demand for plant proteins around the globe. Authored by scientists who have researched and developed patents using BGN, Bambara Groundnut: Utilization and Future Prospects aims to fill this gap. The text provides in-depth coverage on breeding, food and feed utilization, medicinal benefits and future research prospects. Drawing on both indigenous knowledge and cutting-edge research, Bambara Groundnut is the first book to fully explore the potential of this remarkable crop.
    Type of Medium: Online Resource
    Pages: XVIII, 238 p. 65 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030760779
    URL: https://doi.org/10.1007/978-3-030-76077-9
    DOI: 10.1007/978-3-030-76077-9
    DDC: 630
    Language: English
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  • 5
    Online Resource
    Online Resource
    The Almond Tree Genome (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Plant genetics. ; Plant biotechnology. ; Agriculture. ; Plant Genetics. ; Plant Biotechnology. ; Agriculture.
    Description / Table of Contents: Almond genome analysis and breeding -- Labelling Almond Genome: SAM, QTLs and Association mapping -- Identification of natural variation in almond target genes -- Recent advances on almond bitterness expression at genomic and trascriptomic level -- Recent advances on flower self-incompatibility expression at genomic and transcriptomic level -- Molecular basis of abiotic and biotic stresses in almond -- Genomics for fruit quality traits in almond: QTLs vs Association mapping -- Transcriptional changes associated with flower bud dormancy in almond and other Prunus species: DNA sequence motifs, mRNA and miRNA expression, transcription factors, chromatin modifications and phytohormone signaling -- Almond transcriptome analysis using high-throughput sequencing technologies -- Almond miRNA expression and horticultural implications.
    Abstract: This book brings together the latest information on almond genomics and transcriptomics, with a particular focus on cutting-edge findings, tools, and strategies employed in genome sequencing and analysis with regard to the most important agronomic traits. Cultivated almond [(Prunus dulcis (Miller) D. A. Webb, syn. Prunus amygdalus Batsch., Amygdalus communis L., Amygdalus dulcis Mill.)] is a tree crop producing seeds of great economic interest, and adapted to hot and dry climates. Domesticated in Southeast Asia, its small diploid genome and phenotypic diversity make it an ideal model to complement genomics studies on peach, generally considered to be the reference Prunus species. Both represent consanguineous species that evolved in two distinct environments: warmer and more humid in the case of peach, and colder and xerophytic for almond. The advent of affordable whole-genome sequencing, in combination with existing Prunus functional genomics data, has now made it possible to leverage the novel diversity found in almond, providing an unmatched resource for the genetic improvement of this species.
    Type of Medium: Online Resource
    Pages: XVIII, 171 p. 33 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783030303020
    Series Statement: Compendium of Plant Genomes,
    URL: https://doi.org/10.1007/978-3-030-30302-0
    DOI: 10.1007/978-3-030-30302-0
    DDC: 581.35
    Language: English
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  • 6
    Online Resource
    Online Resource
    Cereal Diseases: Nanobiotechnological Approaches for Diagnosis and Management (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Agricultural biotechnology. ; Agronomy. ; Agricultural genome mapping. ; Nanotechnology. ; Agriculture. ; Agricultural Biotechnology. ; Agronomy. ; Agricultural Genetics. ; Nanotechnology. ; Agriculture.
    Description / Table of Contents: Chapter 1. An introduction to rice diseases -- Chapter 2. Bacterial diseases of rice -- Chapter 3. Viral diseases of rice -- Chapter 4. Etiology, epidemiology, and management of maize diseases -- Chapter 5. Viral diseases of maize -- Chapter 6. Barley diseases: Introduction etiology, epidemiology, and their management -- Chapter 7. Identification of new susceptibility gene and its role in plant immunity -- Chapter 8. Breeding strategies for developing disease-resistant wheat: present, past, and future -- Chapter 9. Potential breeding strategies for developing disease-resistant barley: progress, challenges, and applications -- Chapter 10. Economic and Eco-friendly alternatives for the efficient and safe management of wheat diseases -- Chapter 11. Resistance gene identification, cloning, and characterization in plants -- Chapter 12. The role of genetic, genomic, and breeding approaches in the fight against fungal diseases in wheat -- Chapter 13. Disease Resistance genes identification, cloning, and characterization in plants -- Chapter 14. Utilization of Biosensors in the Identification of Bacterial Diseases in Maize -- Chapter 15. Nanomaterials for integrated crop disease managemenT -- Chapter 16. Metallic Nanoparticles and Nano-based bioactive formulations as Nano fungicides for Sustainable Disease Management in Cereals -- Chapter 17. Applications of nano-biotechnological Approaches in Diagnosis and Protection of Wheat Diseases -- Chapter 18. Nanomaterials for the Reduction of Mycotoxins in Cereals.
    Abstract: New ways to improve cereal crops against fungal, bacterial, and viral diseases are covered in this book that was put together by a group of experts. These include genetics, genome editing systems, and nano-biotechnological tools. Cereal crops are mainly the world's leading food crops and feed a large share of the world population. However, external factors, such as pathogens, have often threatened their productivity. Like wheat, rice, maize, oats, barley, millet and storage, etiology, epidemiology, and diseases in cereal crop management. In addition, the importance of crop genetics and genomics in combating pathogens has been discussed. This book offers up-to-date information on new methods, such as the potential of the genome editing system for crop improvement, in particular the CRISPR-Cas system. The current volume also talks about identification, plant breeding, genome editing, and nanotechnology tools that can be used to fight disease in cereal crops. This book is good for students, teachers, and researchers who study biotic stress in cereals, as well as scientists who study nanotechnology, disease resistance, pathogen biology, genome editing, agriculture sciences, and future biotechnology.
    Type of Medium: Online Resource
    Pages: XII, 406 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811931208
    URL: https://doi.org/10.1007/978-981-19-3120-8
    DOI: 10.1007/978-981-19-3120-8
    DDC: 630
    Language: English
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  • 7
    Online Resource
    Online Resource
    Plant Growth-Promoting Microbes for Sustainable Biotic and Abiotic Stress Management (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Symbiosis. ; Plants. ; Stress (Physiology). ; Agronomy. ; Plant diseases. ; Soil science. ; Plant Symbiosis. ; Plant Stress Responses. ; Agronomy. ; Plant Pathology. ; Soil Science.
    Description / Table of Contents: Cyanobacteria and algae as biocontrol agents against fungal and bacterial plant pathogens -- Plant Growth Promoting Rhizobacteria in Amelioration of Abiotic Stresses: A Functional Interplay and Prospective -- Seaweeds as indicators and potential remediators of metal pollution -- Role of microorganisms in managing soil fertility and plant nutrition in sustainable agriculture -- Role of endophytic bacteria in alleviation of heavy metals from an ecosystem -- Microbial enzymes and soil health -- Pseudomonas as plant growth promoting bacteria and its role in alleviation abiotic stress -- Plant growth promoting Rhizobacteria (PGPR) as biocontrol agents against viral protection -- Potential Role of Endophytes in Weeds and Herbicide Tolerance in Plants -- The auspicious role of promoting plant growth of rhizobacteria in the sustainable management of plant diseases -- Microbial bioactive compounds produced by bacteria and fungi and uses in plant health -- Biosynthesis of Nanoparticles by Microorganisms and Applications in Plant Stress Control -- Nano-enabled approaches for the suitable delivery of fertilizer and pesticide for plant growth -- Production of plant hormones from algae and its relation to plant growth -- Role of Trichoderma in agriculture and disease management -- Production of antibiotics from plant growth promoting bacteria and their role in biocontrol of plant diseases -- Role of Phosphate-Solubilising Microorganisms in Agricultural Development -- Cyanobacteria as biofertilizer and its effect under biotic stress -- Microorganism: A potent biological tool to combat Insects and herbivores -- Eco-friendly approaches for the alleviation of root-knot nematodes -- Rhizosphere, Rhizosphere Biology and Rhizospheric Engineering -- Microbial enzymes and role in phytoremidation.
    Abstract: Abiotic and biotic stress factors including drought, salinity, waterlog, temperature extremes, mineral nutrients, heavy metals, plant diseases, nematodes, viruses, and diseases, adversely affect growth as well as yield of crop plants worldwide. Plant growth promoting microorganisms (PGPM) are receiving increasing attention from agronomists and environmentalists as candidates to develop an effective, eco-friendly, and sustainable alternative to conventional agricultural (e.g., chemical fertilizers and pesticide) and remediation (e.g., chelators-enhanced phytoremediation) methods employed to deal with climate change-induced stresses. Recent studies have shown that plant growth promoting bacteria (PGPB), rhizobia, arbuscular mycorrhizal fungi (AMF), cyanobacteria have great potentials in the management of various agricultural and environmental problems. Our intention for this book is to provide up-to-date knowledge of biofertilizer and the roles of microorganisms in plant health, with specific emphasis on the mitigating strategies to combat plant stresses.
    Type of Medium: Online Resource
    Pages: XV, 672 p. 67 illus., 63 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030665876
    URL: https://doi.org/10.1007/978-3-030-66587-6
    DOI: 10.1007/978-3-030-66587-6
    DDC: 581.785
    Language: English
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  • 8
    Online Resource
    Online Resource
    Biochemistry and Cell Biology of Ageing: Part III Biomedical Science (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Aging. ; Cytology. ; Clinical biochemistry. ; Proteins . ; Ageing. ; Cell Biology. ; Medical Biochemistry. ; Protein Biochemistry.
    Description / Table of Contents: Chapter 1: Introduction: Progression of the Science of Ageing -- Chapter 2: Chromatin structure from development to ageing -- Chapter 3: The nuclear envelope in ageing and progeria -- Chapter 4: Mitochondrial DNA mutations and ageing -- Chapter 5: The Proteasome and Ageing -- Chapter 6: Gap junctions and Ageing -- Chapter 7: Cellular senescence and ageing -- Chapter 8: Therapeutic opportunities presented by modulation of cellular senescence -- Chapter 9: Ageing at Molecular Level: Role of MicroRNAs -- Chapter 10: CircRNAandAgeing -- Chapter 11: Extracellular vesicles and cellular ageing -- Chapter 12: Fibrinogen, Coagulation and Ageing -- Chapter 13: An Insight intoPlateletsat Older Age:Cellular and Clinical Perspectives -- Chapter 14: Ageing skeletal muscle: The ubiquitous muscle stem cell -- Chapter 15: Age-related changes in central nervous system 5-hydroxytryptamine signalling and its potential effects on the regulation of lifespan -- Chapter 16: Systems Biology of Ageing.
    Abstract: This, our third book on the Biochemistry and Cell Biology of Ageing in the Subcellular Biochemistry series, expands on the content of Part I, by covering additional biomedical topics. The 16 chapters included here, contributed by international knowledgeable scientists, review these further interesting topics at an advanced level. Following an Introductory chapter, these topics are included: Chromatin Structure from Development to Ageing, the Nuclear Envelope in Ageing and Progeria, Mitochondrial DNA Mutations and Ageing, the Proteasome and Ageing, Gap Junctions and Ageing, Cellular Senescence and Ageing, Therapeutic Opportunities Presented by Modulation of Cellular Senescence, Ageing at Molecular Level: Role of MicroRNAs, CircRNA and Ageing, Extracellular Vesicles and Cellular Ageing,Fibrinogen, Coagulation and Ageing, An Insight into Platelets at Older Age: Cellular and Clinical Perspectives, Ageing Skeletal Muscle: The Ubiquitous Muscle Stem Cell, Age-related Changes in Central Nervous System 5-Hydroxytryptamine Signalling and its Potential effects on the Regulation of Lifespan, and Systems Biology of Ageing. The book is primarily directed to advanced biomedical science and medical students, postgraduates, researchers and academics in the field of Ageing. A further companion volume of the series (Part IV) covering the more Clinical Science aspects will be published soon. The seemingly endless expansion of ageing research continues to throw up important areas, that may well be covered in future volumes, together with updates of rapidly moving subjects. Thus, a further book on Anti-ageing Interventions (Part V) is under production.
    Type of Medium: Online Resource
    Pages: IX, 424 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031214103
    Series Statement: Subcellular Biochemistry, 102
    URL: https://doi.org/10.1007/978-3-031-21410-3
    DOI: 10.1007/978-3-031-21410-3
    DDC: 571.878
    Language: English
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  • 9
    Online Resource
    Online Resource
    Food and Potential Industrial Applications of Bambara Groundnut (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Botany. ; Food science. ; Food security. ; Plant Science. ; Food Science. ; Food Security.
    Description / Table of Contents: 1. Bambara groundnut perspective -- 2. Agricultural production practices of bambara groundnut -- 3. Pre- and post- harvest handling and storage of bambara grains -- 4. Characteristics of bambara groundnut: description, structure and composition -- 5. Limitations to bambara groundnut utilization -- 6. Bambara groundnut starch -- 7. Bambara groundnut protein -- 8. Phytochemicals in bambara groundnut -- 9. Traditional food uses of bambara groundnut -- 10. Bambara groundnut in complementary feeding -- 11. Microbiology and safety of bambara groundnut -- 12. Potential industrial applications of bambara -- 13. Conclusions and future trends.
    Abstract: Bambara groundnut (Vigna subterranea) is a crop native to the Bambara tribe of Mali and is grown as a subsistence crop in Africa. Recent advances in research, however, have brought the crop to the forefront of the sustainable agriculture movement. The Bambara plant is highly drought tolerant and rich in protein and carbohydrates, including starch. These macromolecules have enormous industrial potentials. For example, the starch in Bambara grain has been found to exhibit higher (double) viscosity than conventional corn starch. Modified Bambara groundnut starch has been used to produce edible bioplastics that could be upgraded industrially to suit the fourth industrial revolution shift. Bambara plants are also a natural source of soluble fiber, which is gluten-, lactose- and cholesterol-free, with potential as a stabiliser, thickener and gelling agent as well as a cryoprotectant in frozen products. The health benefits include lowering of cholesterol levels, levelling of blood glucose and as a detoxing aid. Furthermore, several researchers have explored the grain either alone or as composite with cereal and tubers for the development of value-added products. Food and Potential Industrial Applications of Bambara Groundnut presents in a clear, coherent way the research findings on Bambara grain and its status as a promising food and industrial crop.
    Type of Medium: Online Resource
    Pages: XVII, 237 p. 46 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030739201
    URL: https://doi.org/10.1007/978-3-030-73920-1
    DOI: 10.1007/978-3-030-73920-1
    DDC: 580
    Language: English
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  • 10
    Online Resource
    Online Resource
    Bioprocess and Analytics Development for Virus-based Advanced Therapeutics and Medicinal Products (ATMPs) (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Virology. ; Biomedical engineering. ; Biotechnology. ; Microbial genetics. ; Analytical biochemistry. ; Therapeutics. ; Virology. ; Biomedical Engineering and Bioengineering. ; Biotechnology. ; Microbial Genetics. ; Analytical Biochemistry. ; Therapeutics.
    Description / Table of Contents: Chapter 1: Bioprocessing and analytical development for virus-based therapeutics -- Chapter 2: Viral Vector Upstream Processing and Clarification -- Chapter 3: Upstream processing of viral therapeutics: From host cell expansion to virus production -- Chapter 4: Leveraging virus biology and host genetic conflicts for cell line development and engineering for virus-based therapeutics -- Chapter 5: Overview of Current Downstream Processing for Modern Viral Vectors -- Chapter 6: Filtration Principles and Techniques for Bioprocessing of Viral Vector–Based Therapeutics -- Chapter 7: Chromatographic purification of viruses: State of the art and current trends -- Chapter 8: Purifying Viral Vectors - A Review of Chromatography Solutions -- Chapter 9: Particle analytics - Comparative approaches for analysis of viral vectors -- Chapter 10: Phase-Appropriate Potency Assay Development for AAV-based Gene Therapy Products -- Chapter 11: Quantification of virus infectivity – the key assay for the development of viral therapeutics -- Chapter 12: Product-related impurities in therapeutic virus bioprocessing -- Chapter 13: Process Analytical Technologies (PAT) and Quality by Design (QbD) for bioprocessing of virus-based therapeutics -- Chapter 14: Methods and practical considerations in imaging viral therapeutics -- Chapter 15: Application of NMR Spectroscopy in Viral Assembly Characterization -- Chapter 16: Improved Production Strategies for Oncolytic Measles Viruses as a Therapeutic Cancer Treatment -- Chapter 17: Recent Advancements and Challenges in Recombinant Expression for Commercial Production of Virus Like Particles (VLPs) -- Chapter 18: Oncolytic viruses and viral gene therapy vectors: Principles of safety.
    Abstract: This book reviews the knowledge, methods and available techniques in the rapidly advancing field of virus based vaccines and gene therapeutics. It also highlights new innovative tools and interdisciplinary techniques for bioprocess development and analytics of viruses and viral vectors. As such, it provides a timely and highly relevant resource, since current advances in pharmaceutical research have seen the rise of vaccines and advanced therapeutics and medicinal products (ATMPs), that rely on the power of viruses. However, developing bioprocesses and analytics required to create this often called “magic bullet” (i.e. gene therapy) remains an extremely challenging and costly task. This book offers strategies for overcoming hurdles and difficulties within in all the necessary steps of viral vector development - from scalability to purification methods and quality control. The book is intended for researchers working in academia or industry, as well as graduate students pursuing a career in virology.
    Type of Medium: Online Resource
    Pages: XVI, 442 p. 84 illus., 62 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031284892
    URL: https://doi.org/10.1007/978-3-031-28489-2
    DOI: 10.1007/978-3-031-28489-2
    DDC: 579.2
    Language: English
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