Publikationsdatum:
2024-04-11
Beschreibung:
Hyaluronan-based hydrogels are optimal candidates when developing novel combined advanced therapy medicinal products (cATMP), tissue engineering products (TEP), and medical devices. The key physico-chemical properties of hydrogels may hinder, mediate, or stimulate therapeutic potentials borne by standardised cellular substrates in regenerative medicine. Parallel to delivery system or scaffold development, hydrogel functionalisation may be advantageous in specific musculoskeletal interventions or topical applications (e.g. viscosupplementation, soft tissue volumetric supplementation, rehabilitation topical preparations). Optimised combination product developmental workflows enable pragmatic regulatory classification of cell-based preparations. Such aspects will be discussed, as well as sustainable transposition to industrialised production settings. Hyaluronan benefits from extensive hindsight in numerous human and veterinary applications, providing a highly versatile backbone for quasi-infinite structural modification and physico-chemical property modulation. This chapter provides an overview of critical product design considerations and possible therapeutic applications of versatile hyaluronan-based preparations intended for cell therapy delivery, combined with optimised autologous or allogeneic therapeutic cell sources (e.g. platelet-rich plasma, stem cells, banked primary foetal progenitors). Particular focus was set on specific parameters directly impacting product potential in terms of clinical translation and effectiveness for topical wound healing or sub-critical volumetric defect correction and repair stimulation in musculoskeletal regenerative medicine applications.
Schlagwort(e):
Regenerative medicine, Carbon nanotube, Block copolymers, Wound healing, Anticancer therapy, Particles used in imaging
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thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBN Nanotechnology
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thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
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thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences
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thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBP Health systems and services::MBPM Medical administration and management
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thema EDItEUR::P Mathematics and Science::PN Chemistry
Sprache:
Englisch
Format:
image/jpeg
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