ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Springer Nature  (5)
  • American Chemical Society
  • Copernicus
  • 2020-2024  (5)
Collection
Keywords
Publisher
Language
Years
Year
  • 1
    facet.materialart.
    Unknown
    Chapter Developing a Model to Simulate the Effect of Hypothermia on Cerebral Blood Flow and Metabolism (2022)
    Springer Nature | Oxygen Transport to Tissue XLI
    Details
    Publication Date: 2024-04-05
    Description: Hypoxic ischemic encephalopathy (HIE) is a significant cause of death and neurological disability in newborns. Therapeutic hypothermia at 33.5 °C is one of the most common treatments in HIE and generally improves outcome; however 45–55% of injuries still result in death or severe neurodevelopmental disability. We have developed a systems biology model of cerebral oxygen transport and metabolism to model the impact of hypothermia on the piglet brain (the neonatal preclinical animal model) tissue physiology. This computational model is an extension of the BrainSignals model of the adult brain. The model predicts that during hypothermia there is a 5.1% decrease in cerebral metabolism, 1.1% decrease in blood flow and 2.3% increase in cerebral tissue oxygenation saturation. The model can be used to simulate effects of hypothermia on the brain and to help interpret bedside recordings.
    Keywords: Broadband NIRS, Hypothermia, Systems biology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 2
    facet.materialart.
    Unknown
    Understanding Willing Participants, Volume 2 (2021)
    Springer Nature
    Details
    Publication Date: 2024-04-04
    Description: Horrified by the Holocaust, social psychologist Stanley Milgram wondered if he could recreate the Holocaust in the laboratory setting. Unabated for more than half a century, his (in)famous results have continued to intrigue scholars. Based on unpublished archival data from Milgram’s personal collection, volume one of this two-volume set introduces readers to a behind the scenes account showing how during Milgram’s unpublished pilot studies he step-by-step invented his official experimental procedure—how he gradually learnt to transform most ordinary people into willing inflictors of harm. The open access volume two then illustrates how certain innovators within the Nazi regime used the very same Milgram-like learning techniques that with increasing effectiveness gradually enabled them to also transform most ordinary people into increasingly capable executioners of other men, women, and children. Volume two effectively attempts to capture how step-by-step these Nazi innovators attempted to transform the Führer’s wish of a Jewish-free Europe into a frightening reality. By the books’ end the reader will gain an insight into how the seemingly undoable can become increasingly doable.
    Keywords: Psychology ; Personality ; Social psychology ; Psychology ; World War, 1939-1945 ; Psychology—Methodology ; Psychological measurement ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history::NHWR Specific wars and campaigns::NHWR7 Second World War ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history::NHWL Modern warfare ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999::3MPB Early 20th century c 1900 to c 1950::3MPBL c 1940 to c 1949::3MPBLB c 1938 to c 1946 (World War Two period) ; thema EDItEUR::J Society and Social Sciences::JM Psychology::JMB Psychological methodology ; thema EDItEUR::J Society and Social Sciences::JM Psychology::JMS Psychology: the self, ego, identity, personality ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDX History of science
    Language: English
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 3
    facet.materialart.
    Unknown
    Anti-spike antibody response to natural SARS-CoV-2 infection in the general population (2021)
    Springer Nature
    Details
    Publication Date: 2021-10-29
    Description: Understanding the trajectory, duration, and determinants of antibody responses after SARS-CoV-2 infection can inform subsequent protection and risk of reinfection, however large-scale representative studies are limited. Here we estimated antibody response after SARS-CoV-2 infection in the general population using representative data from 7,256 United Kingdom COVID-19 infection survey participants who had positive swab SARS-CoV-2 PCR tests from 26-April-2020 to 14-June-2021. A latent class model classified 24% of participants as ‘non-responders’ not developing anti-spike antibodies, who were older, had higher SARS-CoV-2 cycle threshold values during infection (i.e. lower viral burden), and less frequently reported any symptoms. Among those who seroconverted, using Bayesian linear mixed models, the estimated anti-spike IgG peak level was 7.3-fold higher than the level previously associated with 50% protection against reinfection, with higher peak levels in older participants and those of non-white ethnicity. The estimated anti-spike IgG half-life was 184 days, being longer in females and those of white ethnicity. We estimated antibody levels associated with protection against reinfection likely last 1.5-2 years on average, with levels associated with protection from severe infection present for several years. These estimates could inform planning for vaccination booster strategies.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    Genome-wide association study identifies susceptibility loci for acute myeloid leukemia (2021)
    Springer Nature
    Details
    Publication Date: 2021-10-29
    Description: Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10−8; KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 × 10−10; HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA).
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    Differential power of placebo across major psychiatric disorders: a preliminary meta-analysis and machine learning study (2021)
    Springer Nature
    Details
    Publication Date: 2021-10-29
    Description: The placebo effect across psychiatric disorders is still not well understood. In the present study, we conducted meta-analyses including meta-regression, and machine learning analyses to investigate whether the power of placebo effect depends on the types of psychiatric disorders. We included 108 clinical trials (32,035 participants) investigating pharmacological intervention effects on major depressive disorder (MDD), bipolar disorder (BD) and schizophrenia (SCZ). We developed measures based on clinical rating scales and Clinical Global Impression scores to compare placebo effects across these disorders. We performed meta-analysis including meta-regression using sample-size weighted bootstrapping techniques, and machine learning analysis to identify the disorder type included in a trial based on the placebo response. Consistently through multiple measures and analyses, we found differential placebo effects across the three disorders, and found lower placebo effect in SCZ compared to mood disorders. The differential placebo effects could also distinguish the condition involved in each trial between SCZ and mood disorders with machine learning. Our study indicates differential placebo effect across MDD, BD, and SCZ, which is important for future neurobiological studies of placebo effects across psychiatric disorders and may lead to potential therapeutic applications of placebo on disorders more responsive to placebo compared to other conditions.
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...